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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PDLIM4, XPNPEP3 (from a repository: Tue Aug 13 07:08:25 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins6 (26.09 %)
The number (and %) of the tumor suppressors2 (8.70 %)
Total number of binary PPIs (saturation %)62 (24.51 %)
The number (and %) of affected PPIs22 (35.48 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI4.174
Assortativity coefficient-0.0860
The network average Clustering coefficient0.517
The number (and %) of a zero Clustering coefficients4 (17.39 %)
The number (and %) of a zero Betweenness Centrality9 (39.13 %)


List of the fusions

PPI for parental proteins: XPNPEP3,PDLIM4 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); UBR5 (see 4 fusions); CUL3 (see 1 fusions); VIM (see 1 fusions); XPNPEP3/IDE (see 1 fusions); RBPMS (see 1 fusions); BAG3 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 XPNPEP3parental protein190.144272.376AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
2 PDLIM4parental protein30.33342.000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
3 BAG3oncoprotein40.33320.552BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
4 C1QBPinteractor80.39324.905MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
5 C2orf47interactor41.0000Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
6 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 CHCHD2interactor90.46412.500CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
8 CUL3protein found in more fusions80.28665.890Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
9 DYRK2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
10 ECH1interactor31.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
11 EWSR1oncoprotein70.067119.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
12 IDEprotein found in more fusions31.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
13 LACE1interactor50.8330.667AFG1_ATPase (PF03969, IPR005654): AFG1-like ATPase
14 MRPL53interactor100MRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
15 MRPL57interactor2016.552MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
16 NT5DC2interactor21.00005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
17 OBSL1interactor40.33325.505BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
18 PAK5interactor60.7001.833PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
19 POLDIP2interactor40.6673.619DUF525 (PF04379, IPR007474): ApaG domain
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
20 RBPMSprotein found in more fusions31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 UBR5protein found in more fusions50.6673.600CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SDA1 (PF05285, IPR007949): SDA1
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
22 VIMsuppressor40.6670.667Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
23 ZNF408interactor200zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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