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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins COL4A6, PIR (from a repository: Mon Oct 14 16:00:54 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins13 (22.41 %)
The number (and %) of the tumor suppressors9 (15.52 %)
Total number of binary PPIs (saturation %)201 (12.16 %)
The number (and %) of affected PPIs56 (27.86 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI6.207
Assortativity coefficient-0.2411
The network average Clustering coefficient0.455
The number (and %) of a zero Clustering coefficients10 (17.24 %)
The number (and %) of a zero Betweenness Centrality16 (27.59 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PIR,COL4A6 All fusions
Proteins found in more fusions NFIX (see 3 fusions); APP (see 4 fusions); ACAT2 (see 1 fusions); TKT (see 5 fusions); DCXR (see 2 fusions); VHL (see 1 fusions); RACK1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PIRparental protein520.0862152.081Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
2 COL4A6parental protein40.333116.999C4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
3 ACAT2protein found in more fusions50.6671.167Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ADKinteractor50.7001.300PfkB (PF00294, IPR011611): pfkB family carbohydrate kinase
5 ANXA7suppressor70.4299.908Annexin (PF00191, IPR018502, SM00335): Annexin
6 APPprotein found in more fusions90.143268.507APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
7 ARHGDIAinteractor31.0000Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
8 ASS1suppressor130.303124.069Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
9 BCL3oncoprotein100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
10 C11orf54interactor90.44461.575DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
11 C2orf68interactor100UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
12 CAPGsuppressor80.46412.888Gelsolin (PF00626, IPR007123): Gelsolin repeat
13 CFL1interactor120.333110.068Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
14 CFL2interactor50.8330.797Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
15 CLNS1Ainteractor30.6671.708Voldacs (PF03517): Regulator of volume decrease after cellular swelling
16 DAZAP1interactor150.33360.403RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
17 DCXRprotein found in more fusions50.66727.787adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
18 DSTNinteractor70.38112.261Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
19 FAHD1interactor50.7001.233FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
20 FHsuppressor100.46717.575Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
21 FUBP1oncoprotein40.5003.467DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
22 GNPDA1interactor50.6003.154Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
23 GNPDA2interactor50.7002.000Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
24 GOT1interactor130.26944.208Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
25 GRHPRinteractor30.6670.6672-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
26 GSRinteractor31.0000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
27 HMGCLinteractor100HMGL-like (PF00682, IPR000891): HMGL-like
28 HSPE1interactor100.40024.165Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
29 HTRA2suppressor70.4677.197Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
30 KLHL20interactor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
31 MIFoncoprotein90.32164.894MIF (PF01187, IPR001398): Macrophage migration inhibitory factor (MIF)
32 NANSinteractor80.6076.506NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
33 NFIXoncoprotein200CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
34 NFKBIAoncoprotein21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
35 NXF1interactor90.32119.433NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
36 OSMinteractor21.0000LIF_OSM (PF01291, IPR001581, SM00080): LIF / OSM family
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
37 PARK7suppressor70.40046.780DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
38 PDCD6IPinteractor90.5369.468BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
39 PPIAinteractor70.42951.841Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
40 PPP2CAsuppressor30.6671.000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
41 PSMB2interactor100Proteasome (PF00227, IPR001353): Proteasome subunit
42 RACK1suppressor60.40047.172WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
43 SIN3Aoncoprotein30.6671.000Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
44 SMAD9interactor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
45 SNX3interactor60.4675.197PX (PF00787, IPR001683, SM00312): PX domain
46 SOD1interactor190.26199.684Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
47 SPENoncoprotein100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
48 SRIoncoprotein70.6673.167EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
49 SRXN1interactor30.6670.400ParBc (PF02195, IPR003115): ParB-like nuclease domain
50 STAMinteractor100GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51 SUGT1interactor21.0000CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
52 SUMF1interactor100FGE-sulfatase (PF03781, IPR005532): Sulfatase-modifying factor enzyme 1
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
53 TIA1interactor30.6670.667Calcipressin (PF04847, IPR006931): Calcipressin
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
54 TIAL1interactor50.7002.598RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
55 TKTprotein found in more fusions150.39638.423Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
56 UBE2L3interactor80.4768.633UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
57 UBL7oncoprotein100UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
58 VHLsuppressor60.20085.956Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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