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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MT-ND5, IFITM1 (from a repository: Sat Jul 27 19:19:06 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins3 (14.29 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)61 (29.05 %)
The number (and %) of affected PPIs19 (31.15 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI5.524
Assortativity coefficient-0.0068
The network average Clustering coefficient0.642
The number (and %) of a zero Clustering coefficients6 (28.57 %)
The number (and %) of a zero Betweenness Centrality12 (57.14 %)


List of the fusions

PPI for parental proteins: MT-ND5,IFITM1 All fusions
Proteins found in more fusions GLUL (see 4 fusions); NDUFS3 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MT-ND5parental protein150.343128.250NADH5_C (PF06455, IPR010934): NADH dehydrogenase subunit 5 C-terminus
Proton_antipo_M (PF00361, IPR001750): Proton-conducting membrane transporter
Proton_antipo_N (PF00662, IPR001516): NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
2 IFITM1parental protein40.5006.000CD225 (PF04505, IPR007593): Interferon-induced transmembrane protein
3 ABHD16Ainteractor100Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
4 CD19interactor31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
5 CD81interactor41.0000Tetraspannin (PF00335, IPR018499): Tetraspanin family
6 CR2oncoprotein31.0000C_tripleX (PF02363, IPR003341): Cysteine rich repeat
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
7 ENPP6interactor100Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase
8 FNDC4interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF4808 (PF16066, IPR032073): Domain of unknown function (DUF4808)
9 GLULprotein found in more fusions200Gln-synt_C (PF00120, IPR008146): Glutamine synthetase, catalytic domain
Gln-synt_N (PF03951, IPR008147): Glutamine synthetase, beta-Grasp domain
10 LIG4interactor100APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
11 NDUFA11interactor100.8008.2507kD_coat (PF02495, IPR003411): 7kD viral coat protein
Tim17 (PF02466, IPR003397): Tim17/Tim22/Tim23/Pmp24 family
12 NDUFA12interactor90.9720.250NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
13 NDUFA8interactor81.0000CHCH (PF06747, IPR010625): CHCH domain
Pet191_N (PF10203, IPR018793): Cytochrome c oxidase assembly protein PET191
Cdd1 (PF11731, IPR021725): Pathogenicity locus
14 NDUFA9interactor90.9720.250Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
15 NDUFS3protein found in more fusions100.9720.250Complex1_30kDa (PF00329, IPR001268): Respiratory-chain NADH dehydrogenase, 30 Kd subunit
16 NDUFS4interactor90.9720.250ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
17 NDUFS5interactor81.0000Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa
18 NDUFV1interactor90.9720.250Complex1_51K (PF01512, IPR011538): Respiratory-chain NADH dehydrogenase 51 Kd subunit
NADH_4Fe-4S (PF10589, IPR019575, SM00928): NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
SLBB (PF10531, IPR019554): SLBB domain
19 NDUFV2interactor90.9720.2502Fe-2S_thioredx (PF01257, IPR002023): Thioredoxin-like [2Fe-2S] ferredoxin
20 VAPBinteractor100ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
21 YME1L1interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41

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