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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PARD3B, MAP4K3 (from a repository: Mon Dec 3 17:06:53 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins7 (58.33 %)
The number (and %) of the tumor suppressors1 (8.33 %)
Total number of binary PPIs (saturation %)24 (36.36 %)
The number (and %) of affected PPIs10 (41.67 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI2.833
Assortativity coefficient0.0106
The network average Clustering coefficient0.376
The number (and %) of a zero Clustering coefficients6 (50.00 %)
The number (and %) of a zero Betweenness Centrality7 (58.33 %)


List of the fusions

PPI for parental proteins: MAP4K3,PARD3B All fusions
Proteins found in more fusions SFN (see 1 fusions); COPS5 (see 1 fusions); GRB2 (see 1 fusions); ITSN2 (see 1 fusions); SH3RF1 (see 1 fusions); GAN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 MAP4K3parental protein80.17952.000CNH (PF00780, IPR001180, SM00036): CNH domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
2 PARD3Bparental protein2020.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
3 CEP250interactor100ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
4 COPS5protein found in more fusions41.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
5 GANprotein found in more fusions309.000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
6 GRB2oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
7 ITSN2protein found in more fusions200C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
8 NTRK1oncoprotein70.33338.000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
9 PCBP1oncoprotein31.0000Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
10 SFNsuppressor4037.00014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
11 SH3RF1protein found in more fusions200zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
12 SORBS1interactor21.0000SH3_2 (PF07653, IPR011511): Variant SH3 domain
Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
SCAB-ABD (PF16711, IPR032012): Actin-binding domain of plant-specific actin-binding protein

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