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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MYPN, ZNFX1 (from a repository: Fri Jul 26 14:31:35 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)39
The number (and %) of the onco-proteins11 (28.21 %)
The number (and %) of the tumor suppressors2 (5.13 %)
Total number of binary PPIs (saturation %)71 (9.58 %)
The number (and %) of affected PPIs38 (53.52 %)
The number of possible different fusions8
PPI diameter4
PPI radius2
The average degree of PPI3.128
Assortativity coefficient-0.5622
The network average Clustering coefficient0.300
The number (and %) of a zero Clustering coefficients21 (53.85 %)
The number (and %) of a zero Betweenness Centrality23 (58.97 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MYPN,ZNFX1 All fusions
Proteins found in more fusions DHX8 (see 1 fusions); FYN (see 1 fusions); MIEF1 (see 1 fusions); MCM2 (see 1 fusions); ACTN2 (see 1 fusions); ZNFX1/CSDE1 (see 1 fusions); ZNFX1/DDX27 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYPNparental protein150.095541.538Senescence_reg (PF04520, IPR007608): Senescence regulator
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
2 ZNFX1parental protein230.020896.610zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
3 ACTN2protein found in more fusions31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 ACTN3interactor40.6671.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 AMZ2interactor100Peptidase_M10 (PF00413, IPR001818): Matrixin
Peptidase_M54 (PF07998, IPR012962): Peptidase family M54
6 ANKRD1interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
7 ANKRD23interactor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
8 BAG6interactor308.019DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
9 CAPZA2interactor30.6671.967F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
10 CDK4oncoprotein3061.533Pkinase (PF00069, IPR000719): Protein kinase domain
11 CSDE1oncoprotein21.0000CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
SUZ-C (PF12901, IPR024642): SUZ-C motif
S1-like (PF14444, IPR025223): S1-like
12 CXXC4suppressor100Glycoprotein_G (PF00802, IPR000925): Pneumovirus attachment glycoprotein G
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
13 DDX27protein found in more fusions100Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
14 DENND2Dsuppressor100dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
15 DHX8protein found in more fusions6079.067DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
16 DRC1interactor100GvpK (PF05121, IPR007805): Gas vesicle protein K
Octopine_DH (PF02317, IPR003421): NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain
ApoO (PF09769, IPR019166): Apolipoprotein O
NYD-SP28 (PF14772): Sperm tail
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
LRR19-TM (PF15176): Leucine-rich repeat family 19 TM domain
17 DROSHAinteractor31.0000dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
18 ENO1oncoprotein40.16754.771Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
19 FYNoncoprotein31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
20 GTSE1interactor30.6677.167GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
21 HSF2interactor100HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
22 IMP3interactor100Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
23 LACTBoncoprotein200Beta-lactamase (PF00144, IPR001466): Beta-lactamase
24 MCM2oncoprotein90.143153.105AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
25 MIEF1protein found in more fusions200Mab-21 (PF03281, IPR024810): Mab-21 protein
26 MOV10interactor207.952AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
27 MTA2interactor100BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain
DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
28 NEBoncoprotein21.0000Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
Shal-type (PF11601, IPR021645): Shal-type voltage-gated potassium channels, N-terminal
DUF3410 (PF11890, IPR024531): Domain of unknown function (DUF3410)
DUF3417 (PF11897, IPR024517): Protein of unknown function (DUF3417)
G-patch_2 (PF12656, IPR026822): G-patch domain
NFRKB_winged (PF14465, IPR025220): NFRKB Winged Helix-like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
29 NEBLinteractor21.0000Bac_small_YrzI (PF09501, IPR012655): Probable sporulation protein (Bac_small_yrzI)
Annexin (PF00191, IPR018502, SM00335): Annexin
Nebulin (PF00880, IPR000900, SM00227): Nebulin repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
30 NXF1interactor50.50011.286NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
31 PCDH1interactor100Cadherin_2 (PF08266, IPR013164): Cadherin-like
Protocadherin (PF08374, IPR013585): Protocadherin
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
RGCC (PF15151, IPR029252): Response gene to complement 32 protein family
Cadherin_3 (PF16184): Cadherin-like
32 PDK1interactor200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
33 SCAF11interactor100DUF566 (PF04484, IPR007573): Family of unknown function (DUF566)
Phage_XkdX (PF09693, IPR010022): Phage uncharacterised protein (Phage_XkdX)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
34 SHMT2interactor207.952SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
35 SS18L2interactor100SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
36 TTNinteractor40.5008.667DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
37 TUBA1Cinteractor2023.533Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
38 UGGT1interactor100Glyco_transf_8 (PF01501, IPR002495): Glycosyl transferase family 8
UDP-g_GGTase (PF06427, IPR009448): UDP-glucose:Glycoprotein Glucosyltransferase
39 XPO1interactor70.286381.833CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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