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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MRPL43, C3orf14 (from a repository: Sat Aug 10 04:32:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins2 (5.56 %)
The number (and %) of the tumor suppressors1 (2.78 %)
Total number of binary PPIs (saturation %)180 (28.57 %)
The number (and %) of affected PPIs34 (18.89 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI9.556
Assortativity coefficient-0.2195
The network average Clustering coefficient0.602
The number (and %) of a zero Clustering coefficients6 (16.67 %)
The number (and %) of a zero Betweenness Centrality11 (30.56 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C3orf14,MRPL43 All fusions
Proteins found in more fusions COPS5 (see 1 fusions); FXR2 (see 1 fusions); NPM1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C3orf14parental protein100DUF4570 (PF15134, IPR028006): Domain of unknown function (DUF4570)
2 MRPL43parental protein330.261499.168L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
3 AKAP5interactor100WSK (PF03832, IPR001573): WSK motif
4 ARRB2interactor50.9000.182Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5 CAND1interactor140.48726.148Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6 CASQ2interactor40.6670.382Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
7 CEP89interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
8 COPS5protein found in more fusions90.6794.598JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
9 DDX56interactor41.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 FXR2protein found in more fusions31.0000Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
11 GLSinteractor21.0000Glutaminase (PF04960, IPR015868): Glutaminase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
12 HNRNPA1interactor180.50738.798RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
13 ITGA4interactor80.6673.932FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
14 LAMTOR3interactor50.5002.567MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
15 MALSU1interactor71.0000RsfS (PF02410, IPR025656): Ribosomal silencing factor during starvation
16 MRPL1interactor150.8104.844CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
17 MRPL20interactor110.7825.200Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
Ribosomal_L20 (PF00453, IPR005813): Ribosomal protein L20
18 MRPL39interactor170.65418.368TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
19 MRPL4interactor170.62527.168Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
20 MRPL40interactor110.9270.783MRP-L28 (PF09812, IPR019192): Mitochondrial ribosomal protein L28
21 MRPL42interactor120.8485.182MRP-S32 (PF10210, IPR019346): Mitochondrial 28S ribosomal protein S32
22 MRPL44interactor150.68615.579dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
23 MRPL47interactor160.72513.260MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
24 MRPL50interactor130.8592.799Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
25 MRPL58interactor180.62726.994RF-1 (PF00472, IPR000352): RF-1 domain
26 MRPL9interactor150.8104.844Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
27 MRPS30interactor160.7587.744PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
28 NACC1interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
29 NDUFA2interactor40.5001.400L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
30 NDUFAF5interactor200Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
31 NPM1suppressor150.47326.922Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
32 RPS18interactor100.53310.772Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
33 RPS8interactor170.52231.934Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
34 SLKinteractor100Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TMPIT (PF07851, IPR012926): TMPIT-like protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
PKK (PF12474, IPR022165): Polo kinase kinase
35 SRPK1interactor41.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
36 VCAM1interactor60.8670.432C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain

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