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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EBF3, GON7 (from a repository: Mon Oct 14 16:18:40 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins8 (38.10 %)
The number (and %) of the tumor suppressors1 (4.76 %)
Total number of binary PPIs (saturation %)67 (31.90 %)
The number (and %) of affected PPIs19 (28.36 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI5.714
Assortativity coefficient0.0298
The network average Clustering coefficient0.673
The number (and %) of a zero Clustering coefficients2 (9.52 %)
The number (and %) of a zero Betweenness Centrality10 (47.62 %)


List of the fusions

PPI for parental proteins: GON7,EBF3 All fusions
Proteins found in more fusions HSF1 (see 3 fusions); PPME1 (see 1 fusions); CBS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 GON7parental protein150.371123.167DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
2 EBF3parental protein40.16774.000TIG (PF01833, IPR002909): IPT/TIG domain
COE1_DBD (PF16422, IPR032200): Transcription factor COE1 DNA-binding domain
COE1_HLH (PF16423, IPR032201): Transcription factor COE1 helix-loop-helix domain
3 ALADoncoprotein71.0000ALAD (PF00490, IPR001731, SM01004): Delta-aminolevulinic acid dehydratase
4 ARPC1Ainteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 ARPC1Binteractor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
6 CBSprotein found in more fusions50.6677.000CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
7 DBNLinteractor90.7225.833RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
8 FBXW7suppressor40.333128.000Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
9 FOXC2oncoprotein200Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 GPN1interactor80.8213.167ATP_bind_1 (PF03029, IPR004130): Conserved hypothetical ATP binding protein
NB-ARC (PF00931, IPR002182): NB-ARC domain
11 HSF1protein found in more fusions70.400152.833DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
12 HSPBP1interactor90.72231.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Rcd1 (PF04078, IPR007216): Cell differentiation family, Rcd1-like
HEAT_EZ (PF13513): HEAT-like repeat
13 JUNoncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
14 LAGE3interactor41.0000Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
15 OGTinteractor71.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
16 OSGEPinteractor60.8001.333Peptidase_M22 (PF00814, IPR000905): Glycoprotease family
17 P3H1interactor90.7227.333TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
18 PPME1protein found in more fusions81.0000Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
19 TP53RKoncoprotein41.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
20 TPRKBinteractor100.40050.333CGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
21 ZNF423oncoprotein100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zinc_ribbon_9 (PF14369): zinc-ribbon
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger

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