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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)140
The number (and %) of the onco-proteins34 (24.29 %)
The number (and %) of the tumor suppressors19 (13.57 %)
Total number of binary PPIs (saturation %)1640 (16.86 %)
The number (and %) of affected PPIs138 (8.41 %)
The number of possible different fusions22
PPI diameter4
PPI radius3
The average degree of PPI22.629
Assortativity coefficient-0.0804
The network average Clustering coefficient0.650
The number (and %) of a zero Clustering coefficients7 (5.00 %)
The number (and %) of a zero Betweenness Centrality20 (14.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PSMB1,BRMS1L All fusions
Proteins found in more fusions PSMC2 (see 1 fusions); EXOC5 (see 1 fusions); EXOSC6 (see 1 fusions); HDAC1 (see 1 fusions); PSMB3 (see 1 fusions); SHFM1/BAG3 (see 1 fusions); VHL (see 1 fusions); MYC (see 2 fusions); PSME3 (see 2 fusions); PSMB7 (see 2 fusions); ACTN2 (see 1 fusions); PSMA7 (see 2 fusions); AMOTL2 (see 1 fusions); UBC (see 4 fusions); FANCG (see 1 fusions); SRSF2 (see 1 fusions); BAG3 (see 4 fusions); FKBP8 (see 1 fusions); MCM2 (see 1 fusions); EPAS1 (see 1 fusions); PSMC5 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PSMB1parental protein1190.1917083.024Proteasome (PF00227, IPR001353): Proteasome subunit
2 BRMS1Lparental protein190.345531.010Sds3 (PF08598, IPR013907): Sds3-like
Tup_N (PF08581, IPR013890): Tup N-terminal
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
3 ACTN2protein found in more fusions40.33349.428CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4 ADRM1interactor400.9089.297Proteasom_Rpn13 (PF04683, IPR006773): Proteasome complex subunit Rpn13 ubiquitin receptor
GET2 (PF08690, IPR028143): GET complex subunit GET2
RPN13_C (PF16550, IPR032368): UCH-binding domain
5 AMFRoncoprotein250.73228.079CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
6 AMOTL2protein found in more fusions6057.996HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
7 AP3M1interactor71.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
8 ASNA1interactor80.9290.258ArsA_ATPase (PF02374, IPR025723): Anion-transporting ATPase
9 BAG3oncoprotein260.70744.035BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
10 BCL3oncoprotein208.630Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
11 BRMS1suppressor120.8555.124Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
12 CASP4interactor100CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
13 CCT5interactor140.38570.846Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
14 CDKN1Bsuppressor30.6670.125CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
15 CFTRsuppressor100.8610.497ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
16 CLIC4oncoprotein80.8211.924GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
17 DCP2interactor100DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
18 DDB2suppressor80.57119.549WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
19 DEUP1suppressor50.33394.544APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
20 DSTYKinteractor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
21 EPAS1suppressor80.47663.155Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein
HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
PAS (PF00989, IPR013767, SM00091): PAS fold
HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
PAS_11 (PF14598): PAS domain
22 EXOC5protein found in more fusions31.0000Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
23 EXOSC6protein found in more fusions71.0000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
24 FANCGsuppressor200BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
25 FBXO28interactor50.4004.723Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
F-box (PF00646, IPR001810, SM00256): F-box domain
FAM76 (PF16046, IPR032017): FAM76 protein
26 FKBP8protein found in more fusions330.88126.983FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
27 FN1oncoprotein290.414294.940fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
28 FOXK1interactor110.636236.094Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
29 FOXK2interactor110.76454.844FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
30 HAUS2interactor40.33322.912DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
31 HDAC1suppressor230.303544.902FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
32 HDAC2suppressor170.517361.379Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
33 HECW2interactor80.381137.254C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
34 HNRNPA2B1oncoprotein180.51029.120RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
35 HSD17B10interactor60.8000.439adh_short (PF00106, IPR002198): short chain dehydrogenase
36 ING1suppressor110.691246.899PHD (PF00628, IPR019787, SM00249): PHD-finger
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
37 ING2suppressor90.9440.872PHD (PF00628, IPR019787, SM00249): PHD-finger
S1FA (PF04689, IPR006779): DNA binding protein S1FA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
38 INSIG2interactor150.9240.872INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
39 IQCB1interactor170.75711.990DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765)
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
40 ITGA4interactor230.50654.876FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
41 KIFC3oncoprotein70.333132.003Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
42 KRT13interactor30.33319.877Filament (PF00038, IPR001664): Intermediate filament protein
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
Keratin_2_head (PF16208, IPR032444): Keratin type II head
43 KRT15interactor60.333200.408Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
44 LACC1interactor21.0000Cu-oxidase_4 (PF02578, IPR003730): Multi-copper polyphenol oxidoreductase laccase
45 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
46 MCM2oncoprotein280.373130.222AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
47 MED4interactor80.32121.618Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
48 MID1oncoprotein170.79218.825Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
49 MID2interactor110.489172.045fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
50 MRPS9interactor60.7332.484Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
51 MXD1oncoprotein61.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
52 MYConcoprotein280.519248.364HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
53 NOTCH2suppressor2030.614Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
54 PARK2suppressor470.660218.417IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
55 PASKinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PAS_8 (PF13188, IPR000014): PAS domain
PAS_9 (PF13426, IPR000014): PAS domain
56 PCK1interactor160.7679.211PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
57 PEX19interactor41.0000Pex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
58 PGK1interactor90.6942.196PGK (PF00162, IPR001576): Phosphoglycerate kinase
59 PLK1suppressor160.8257.104Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
60 POMPinteractor240.76326.123UMP1 (PF05348, IPR008012): Proteasome maturation factor UMP1
61 PPP4R3Ainteractor70.33353.942Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
62 PSEN1oncoprotein60.7002.567Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
63 PSMA1interactor680.468854.126Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
64 PSMA2interactor640.550262.153Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
65 PSMA3interactor650.515725.795Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
66 PSMA4interactor550.624127.912Proteasome (PF00227, IPR001353): Proteasome subunit
U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
67 PSMA5oncoprotein650.497353.819Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
68 PSMA6interactor640.527301.227Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
69 PSMA7protein found in more fusions620.574193.431Proteasome (PF00227, IPR001353): Proteasome subunit
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
70 PSMA8interactor320.9295.131Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
Myb_DNA-bind_5 (PF13873, IPR028002): Myb/SANT-like DNA-binding domain
71 PSMB10interactor160.9170.901Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
72 PSMB2interactor570.590228.629Proteasome (PF00227, IPR001353): Proteasome subunit
73 PSMB3protein found in more fusions660.496384.262Proteasome (PF00227, IPR001353): Proteasome subunit
74 PSMB4interactor590.576198.405Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Proteasome (PF00227, IPR001353): Proteasome subunit
75 PSMB5interactor590.566322.151Proteasome (PF00227, IPR001353): Proteasome subunit
76 PSMB6interactor530.66880.333DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502)
Proteasome (PF00227, IPR001353): Proteasome subunit
77 PSMB7protein found in more fusions530.68997.429Proteasome (PF00227, IPR001353): Proteasome subunit
Pr_beta_C (PF12465, IPR024689): Proteasome beta subunits C terminal
78 PSMB8interactor430.82534.753Proteasome (PF00227, IPR001353): Proteasome subunit
79 PSMB9interactor430.82519.366Proteasome (PF00227, IPR001353): Proteasome subunit
80 PSMC1interactor480.77649.407AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
81 PSMC2protein found in more fusions530.72581.853AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
82 PSMC3interactor500.719277.049AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
83 PSMC4interactor480.760182.486AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
NTPase_1 (PF03266, IPR004948): NTPase
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
AAA_16 (PF13191): AAA ATPase domain
84 PSMC5protein found in more fusions510.74997.532AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
85 PSMC6interactor470.76886.672AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
86 PSMD1interactor480.77069.474PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
87 PSMD11interactor480.73692.021DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
88 PSMD12interactor460.84020.661Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
PCI (PF01399, IPR000717, SM00088): PCI domain
89 PSMD13interactor450.787142.026Mitovir_RNA_pol (PF05919, IPR008686): Mitovirus RNA-dependent RNA polymerase
PCI (PF01399, IPR000717, SM00088): PCI domain
90 PSMD14interactor490.77835.925JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
91 PSMD2oncoprotein530.670112.744PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
92 PSMD3interactor510.678123.761Rpn3_C (PF08375, IPR013586): Proteasome regulatory subunit C-terminal
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
TSKS (PF15358, IPR028214): Testis-specific serine kinase substrate
93 PSMD4interactor430.87216.463UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
94 PSMD5interactor390.88712.693Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
95 PSMD6interactor470.78252.489RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
96 PSMD7interactor460.79956.026JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
97 PSMD8interactor420.9088.374CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
98 PSME1interactor300.83310.149PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
RNase_H2-Ydr279 (PF09468, IPR019024): Ydr279p protein family (RNase H2 complex component)
99 PSME2interactor310.79516.448PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
100 PSME3protein found in more fusions320.71040.707PA28_alpha (PF02251, IPR003185): Proteasome activator pa28 alpha subunit
PA28_beta (PF02252, IPR003186): Proteasome activator pa28 beta subunit
101 PSME4interactor180.8762.701Filament (PF00038, IPR001664): Intermediate filament protein
HEAT (PF02985, IPR000357): HEAT repeat
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
BLM10_mid (PF16507, IPR032430): Proteasome-substrate-size regulator, mid region
102 PSMG3interactor120.9090.762PAC3 (PF10178, IPR018788): Proteasome assembly chaperone 3
103 PYCRLinteractor81.0000F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
P5CR_dimer (PF14748, IPR029036): Pyrroline-5-carboxylate reductase dimerisation
104 RAD23Aoncoprotein410.80978.950UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
105 RBBP4oncoprotein140.505326.781eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
106 RBBP7suppressor120.80325.571WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
107 RBM8Ainteractor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
108 RBP1suppressor31.0000Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
109 RIOK3interactor31.0000RIO1 (PF01163, IPR018934): RIO1 family
110 RPL10Ainteractor110.8363.541Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
111 RPL24interactor100.7789.726MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
112 RPL5suppressor140.61520.233Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
113 RPL7Ainteractor120.7128.867Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
114 RPP30interactor30.6670.095RNase_P_p30 (PF01876, IPR002738): RNase P subunit p30
115 RPP38interactor81.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
116 RPS15Ainteractor170.50733.676Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
117 RPS23interactor81.0000Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
118 SAP30interactor130.73138.190Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
119 SEC13interactor50.5001.700WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
120 SERPINB2interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
121 SERPINE1interactor31.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
122 SF3A1interactor90.63936.208TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Surp (PF01805, IPR000061, SM00648): Surp module
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
123 SHFM1protein found in more fusions340.709297.480CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
124 SIN3Aoncoprotein170.419400.835Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
125 SLX1Binteractor150.9430.767GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
126 SNX3interactor40.6672.000PX (PF00787, IPR001683, SM00312): PX domain
127 SRSF2oncoprotein100.5566.180RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
128 SUGT1interactor70.5711.973CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
129 SYVN1interactor170.9750.300Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
130 TRAF1oncoprotein50.6672.476HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
131 TRIM27oncoprotein120.291106.024IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
132 UBCprotein found in more fusions540.426889.557ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
133 UBE2Ainteractor80.5248.156UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
134 UBE2V1interactor80.3939.541UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
135 UBE4Bsuppressor60.30047.074DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
DUF4568 (PF15132, IPR027919): Domain of unknown function (DUF4568)
136 UCHL5oncoprotein390.91917.107Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
137 UFM1interactor30.6671.000Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
138 UNKinteractor60.26777.022MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
139 VCAM1interactor230.52259.239C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
140 VHLsuppressor200.345292.838Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain

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