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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPAIN, ZBTB17 (from a repository: Wed Jan 20 18:35:09 2021)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins11 (30.56 %)
The number (and %) of the tumor suppressors10 (27.78 %)
Total number of binary PPIs (saturation %)97 (15.40 %)
The number (and %) of affected PPIs35 (36.08 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI4.500
Assortativity coefficient-0.2907
The network average Clustering coefficient0.364
The number (and %) of a zero Clustering coefficients14 (38.89 %)
The number (and %) of a zero Betweenness Centrality17 (47.22 %)


List of the fusions

PPI for parental proteins: RPAIN,ZBTB17 All fusions
Proteins found in more fusions HSPB1 (see 4 fusions); RPA1 (see 1 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); BCL6 (see 2 fusions); EP300 (see 1 fusions); MYC (see 1 fusions); HCFC1 (see 2 fusions); TP53 (see 3 fusions); TOPBP1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 RPAINparental protein90.028434.000RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal
RPA_interact_M (PF14767, IPR028155): Replication protein A interacting middle
RPA_interact_C (PF14768, IPR028159): Replication protein A interacting C-terminal
2 ZBTB17parental protein260.123602.680BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
3 ADH6interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
4 BCL6oncoprotein50.8330.333BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
5 CDCA5interactor200Sororin (PF09666, IPR018605): Sororin protein
6 CDKN2Asuppressor60.8002.083Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
7 CLNKinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
8 CYP17A1interactor100p450 (PF00067, IPR001128): Cytochrome P450
9 DACT1suppressor21.0000Dapper (PF15268, IPR024843): Dapper
10 DIS3interactor100RNB (PF00773, SM00955): RNB domain
rve (PF00665, IPR001584): Integrase core domain
PIN_4 (PF13638, IPR002716): PIN domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
11 DNMT3Asuppressor21.0000DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
12 DVL2interactor40.6674.642DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
13 EP300oncoprotein80.47610.550Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
14 GFI1oncoprotein100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
15 GSTA1interactor200GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
16 HCFC1protein found in more fusions60.30060.226fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
17 HSP90AA1oncoprotein110.44425.350HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
18 HSPB1oncoprotein90.57184.687HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19 HUWE1oncoprotein80.76236.421BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
20 IRF8suppressor200IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
21 ITGB5interactor21.0000EGF_2 (PF07974, IPR013111): EGF-like domain
Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain
Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain
Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain
PSI_integrin (PF17205): Integrin plexin domain
22 KLF5suppressor40.6671.400zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
23 MAGEA4interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
24 MAXsuppressor70.46756.738ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SlyX (PF04102, IPR007236): SlyX
25 MYConcoprotein130.39449.544HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
26 MYCNoncoprotein40.8330.500HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
27 RPA1suppressor70.333176.151Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
28 RPA2oncoprotein70.333252.299RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
29 TMPRSS11Asuppressor100SEA (PF01390, IPR000082, SM00200): SEA domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
DUF4179 (PF13786, IPR025436): Domain of unknown function (DUF4179)
30 TNS4interactor100PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
31 TOPBP1protein found in more fusions3021.899BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
32 TP53suppressor130.394164.163DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
33 UBR7interactor100PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
34 YWHAQinteractor31.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
35 ZBTB4suppressor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
SPX (PF03105, IPR004331): SPX domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
36 ZBTB49interactor30.6670.333BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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