Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins RPAIN, ZBTB17 (from a repository: Wed Jan 20 18:35:09 2021)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 36 The number (and %) of the onco-proteins 11 (30.56 %) The number (and %) of the tumor suppressors 10 (27.78 %) Total number of binary PPIs (saturation %) 97 (15.40 %) The number (and %) of affected PPIs 35 (36.08 %) The number of possible different fusions 11 PPI diameter 5 PPI radius 3 The average degree of PPI 4.500 Assortativity coefficient -0.2907 The network average Clustering coefficient 0.364 The number (and %) of a zero Clustering coefficients 14 (38.89 %) The number (and %) of a zero Betweenness Centrality 17 (47.22 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: RPAIN,ZBTB17	All fusions
Proteins found in more fusions	HSPB1 (see 4 fusions); RPA1 (see 1 fusions); HSP90AA1 (see 2 fusions); HUWE1 (see 2 fusions); BCL6 (see 2 fusions); EP300 (see 1 fusions); MYC (see 1 fusions); HCFC1 (see 2 fusions); TP53 (see 3 fusions); TOPBP1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	RPAIN	parental protein	9	0.028	434.000	RPA_interact_N (PF14766, IPR028158): Replication protein A interacting N-terminal RPA_interact_M (PF14767, IPR028155): Replication protein A interacting middle RPA_interact_C (PF14768, IPR028159): Replication protein A interacting C-terminal
2	ZBTB17	parental protein	26	0.123	602.680	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
3	ADH6	interactor	1	0	0	ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
4	BCL6	oncoprotein	5	0.833	0.333	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DZR (PF12773, IPR025874): Double zinc ribbon zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
5	CDCA5	interactor	2	0	0	Sororin (PF09666, IPR018605): Sororin protein
6	CDKN2A	suppressor	6	0.800	2.083	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
7	CLNK	interactor	1	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
8	CYP17A1	interactor	1	0	0	p450 (PF00067, IPR001128): Cytochrome P450
9	DACT1	suppressor	2	1.000	0	Dapper (PF15268, IPR024843): Dapper
10	DIS3	interactor	1	0	0	RNB (PF00773, SM00955): RNB domain rve (PF00665, IPR001584): Integrase core domain PIN_4 (PF13638, IPR002716): PIN domain Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain Rrp44_S1 (PF17215): S1 domain
11	DNMT3A	suppressor	2	1.000	0	DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase PWWP (PF00855, IPR000313, SM00293): PWWP domain
12	DVL2	interactor	4	0.667	4.642	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
13	EP300	oncoprotein	8	0.476	10.550	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
14	GFI1	oncoprotein	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
15	GSTA1	interactor	2	0	0	GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
16	HCFC1	protein found in more fusions	6	0.300	60.226	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
17	HSP90AA1	oncoprotein	11	0.444	25.350	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
18	HSPB1	oncoprotein	9	0.571	84.687	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
19	HUWE1	oncoprotein	8	0.762	36.421	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
20	IRF8	suppressor	2	0	0	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
21	ITGB5	interactor	2	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain Integrin_b_cyt (PF08725, IPR014836): Integrin beta cytoplasmic domain Integrin_B_tail (PF07965, IPR012896): Integrin beta tail domain Integrin_beta (PF00362, IPR002369, SM00187): Integrin, beta chain PSI_integrin (PF17205): Integrin plexin domain
22	KLF5	suppressor	4	0.667	1.400	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
23	MAGEA4	interactor	1	0	0	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
24	MAX	suppressor	7	0.467	56.738	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SlyX (PF04102, IPR007236): SlyX
25	MYC	oncoprotein	13	0.394	49.544	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
26	MYCN	oncoprotein	4	0.833	0.500	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
27	RPA1	suppressor	7	0.333	176.151	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
28	RPA2	oncoprotein	7	0.333	252.299	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
29	TMPRSS11A	suppressor	1	0	0	SEA (PF01390, IPR000082, SM00200): SEA domain Trypsin (PF00089, IPR001254, SM00020): Trypsin DUF4179 (PF13786, IPR025436): Domain of unknown function (DUF4179)
30	TNS4	interactor	1	0	0	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
31	TOPBP1	protein found in more fusions	3	0	21.899	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
32	TP53	suppressor	13	0.394	164.163	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
33	UBR7	interactor	1	0	0	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
34	YWHAQ	interactor	3	1.000	0	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
35	ZBTB4	suppressor	1	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region SPX (PF03105, IPR004331): SPX domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
36	ZBTB49	interactor	3	0.667	0.333	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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