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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MSLN, ATRIP (from a repository: Thu Nov 21 02:48:33 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins13 (24.53 %)
The number (and %) of the tumor suppressors7 (13.21 %)
Total number of binary PPIs (saturation %)171 (12.41 %)
The number (and %) of affected PPIs51 (29.82 %)
The number of possible different fusions11
PPI diameter5
PPI radius3
The average degree of PPI5.585
Assortativity coefficient-0.1896
The network average Clustering coefficient0.633
The number (and %) of a zero Clustering coefficients9 (16.98 %)
The number (and %) of a zero Betweenness Centrality25 (47.17 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATRIP,MSLN All fusions
Proteins found in more fusions ATR (see 1 fusions); FAM208B (see 2 fusions); MCM7 (see 2 fusions); PRKDC (see 3 fusions); TOPBP1 (see 2 fusions); MSH2 (see 1 fusions); RPA1 (see 1 fusions); HNRNPUL1 (see 1 fusions); MCM2 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATRIPparental protein390.1091695.474Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
2 MSLNparental protein120.212729.793Mesothelin (PF06060, IPR010335): Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
3 ATMsuppressor150.52742.219FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 ATP6V1Ainteractor20486.173ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
5 ATRsuppressor190.366117.992FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
6 BRCA1suppressor140.44933.402BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
7 C1orf94interactor200DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
8 CCDC28Binteractor100DUF4061 (PF13270, IPR025271): Domain of unknown function (DUF4061)
9 CDC23interactor200ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
10 CDC6oncoprotein50.9000.333Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
AAA_22 (PF13401, IPR003593): AAA domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
11 CDK16oncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
12 CDK9protein found in more fusions61.0000Pkinase (PF00069, IPR000719): Protein kinase domain
13 CEP164interactor21.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
WW (PF00397, IPR001202, SM00456): WW domain
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
14 CINPinteractor21.0000Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
15 CLK2interactor70.60025.413DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
16 FAAP24interactor31.0000Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_2 (PF12826): Helix-hairpin-helix motif
17 FAM156Ainteractor100PGC7_Stella (PF15549, IPR029096): PGC7/Stella/Dppa3 domain
18 FAM208Bprotein found in more fusions31.0000DUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
19 GDAinteractor30.6671.000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
20 HERC2interactor50.8330.286ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
21 HNRNPUL1protein found in more fusions70.9330.222Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
22 IKBKGinteractor50.8330.333CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
23 LAMTOR3interactor70.476102.540MAPKK1_Int (PF08923, IPR015019): Mitogen-activated protein kinase kinase 1 interacting
24 LNX1interactor50.333450.827PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
25 MCM2oncoprotein120.58230.872AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
26 MCM7protein found in more fusions80.5716.900MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
27 METTL21Aoncoprotein21.0000Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
28 MID2interactor50.5003.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
29 MOSoncoprotein21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
30 MPV17interactor50.8001.333Mpv17_PMP22 (PF04117, IPR007248): Mpv17 / PMP22 family
31 MRM3interactor30.6671.000SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
32 MRPL1interactor31.0000CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
33 MRPL16interactor31.0000Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
34 MRPL28interactor40.6672.000Ribosomal_L28 (PF00830, IPR001383): Ribosomal L28 family
35 MSH2suppressor100.8069.233MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
36 MX2interactor200Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
37 NBNsuppressor100.8008.208FHA (PF00498, IPR000253, SM00240): FHA domain
Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
NIBRIN_BRCT_II (PF16508, IPR032429): Second BRCT domain on Nijmegen syndrome breakage protein
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
38 NDUFB5interactor41.0000NDUF_B5 (PF09781, IPR019173): NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit
39 NDUFB9interactor41.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
40 NPEPL1interactor21.0000Peptidase_M17 (PF00883, IPR000819): Cytosol aminopeptidase family, catalytic domain
41 PNKDinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
42 POLR1Cinteractor21.0000RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
43 PRKDCprotein found in more fusions90.8213.785FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
44 RALAoncoprotein31.0000ArgK (PF03308, IPR005129): ArgK protein
Ras (PF00071, IPR001806, SM00173): Ras family
ThiF (PF00899, IPR000594): ThiF family
45 RPA1suppressor150.58233.527Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
46 RPA2oncoprotein110.655543.017RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
47 RPA3interactor110.66711.788Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
48 RSG1interactor100Ras (PF00071, IPR001806, SM00173): Ras family
49 SCG2interactor100Granin (PF01271, IPR001990): Granin (chromogranin or secretogranin)
50 SPRY2suppressor31.0000KAR9 (PF08580, IPR013889): Yeast cortical protein KAR9
Sprouty (PF05210, IPR007875): Sprouty protein (Spry)
51 TIMELESSinteractor21.0000Myc_N (PF01056, IPR012682): Myc amino-terminal region
TIMELESS (PF04821, IPR006906): Timeless protein
TIMELESS_C (PF05029, IPR007725): Timeless protein C terminal region
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
52 TOPBP1protein found in more fusions80.8571.500BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
53 ZBTB43interactor40.333395.827BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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