Find Fusion Network

Fusion ID:
Protein names:

Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DHPS, IMMP2L (from a repository: Sat Jul 13 16:02:22 2019)

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Force Directed
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)40
The number (and %) of the onco-proteins10 (25.00 %)
The number (and %) of the tumor suppressors1 (2.50 %)
Total number of binary PPIs (saturation %)84 (10.77 %)
The number (and %) of affected PPIs39 (46.43 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI3.650
Assortativity coefficient-0.4974
The network average Clustering coefficient0.411
The number (and %) of a zero Clustering coefficients15 (37.50 %)
The number (and %) of a zero Betweenness Centrality24 (60.00 %)


List of the fusions

PPI for parental proteins: DHPS,IMMP2L All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); ARIH1 (see 4 fusions); HSF1 (see 3 fusions); CTPS2 (see 1 fusions); DHPS (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 DHPSparental protein380.0481317.833DS (PF01916, IPR002773): Deoxyhypusine synthase
2 IMMP2Lparental protein100Peptidase_S24 (PF00717, IPR019759): Peptidase S24-like
Peptidase_S26 (PF10502, IPR019533): Signal peptidase, peptidase S26
DUF2798 (PF11391, IPR021529): Protein of unknown function (DUF2798)
3 AAMPinteractor41.0000PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 ACTR2interactor60.4007.667Actin (PF00022, IPR004000, SM00268): Actin
5 ANKMY2interactor60.46711.667zf-MYND (PF01753, IPR002893): MYND finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
zf-C6H2 (PF15801, IPR031615): zf-MYND-like zinc finger, mRNA-binding
6 ANP32Boncoprotein31.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
7 ARF6oncoprotein100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
8 ARIH1protein found in more fusions31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
9 ARPC1Binteractor50.5004.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
10 BRCA1suppressor40.33341.667BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
11 BYSLinteractor100Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
12 CDK17interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
13 CTPS2protein found in more fusions41.0000CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
14 DPP8interactor21.0000DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
15 EIF5Ainteractor21.0000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
16 EIF5A2interactor30.6671.000EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
17 HNRNPDoncoprotein50.16778.000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 HNRNPFinteractor50.40052.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
19 HSF1protein found in more fusions90.46412.000DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
20 KCNAB3interactor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
21 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
22 NIF3L1interactor60.4008.667NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
23 NUDT18interactor100NUDIX (PF00293, IPR000086): NUDIX domain
24 PLIN3interactor70.6673.333Perilipin (PF03036, IPR004279): Perilipin family
25 PPP2R5Dinteractor30.6670.667B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
26 PTPRHoncoprotein100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
27 RAB27Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
28 RELoncoprotein30.6671.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
29 RPA3interactor60.40051.667Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
30 RPL9interactor21.0000Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
31 SAE1interactor100ThiF (PF00899, IPR000594): ThiF family
32 SPHK1interactor100DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
33 SRP9interactor60.5336.500SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
34 SRRM2interactor21.0000cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Pap_E4 (PF02711, IPR003861): E4 protein
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
35 SURF2interactor40.6671.500SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
36 SUSD4interactor100Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
37 TIRAPinteractor200TIR_2 (PF13676, IPR000157): TIR domain
38 VASH1interactor100Vasohibin (PF14822, IPR028131): Vasohibin
39 WDYHV1interactor100Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase
40 ZNF138interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain

B a c k    t o    T o p ⇑