Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FERMT3, ARHGAP26 (from a repository: Thu Aug 22 21:49:51 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins13 (29.55 %)
The number (and %) of the tumor suppressors3 (6.82 %)
Total number of binary PPIs (saturation %)92 (9.73 %)
The number (and %) of affected PPIs42 (45.65 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.545
Assortativity coefficient-0.2898
The network average Clustering coefficient0.397
The number (and %) of a zero Clustering coefficients16 (36.36 %)
The number (and %) of a zero Betweenness Centrality25 (56.82 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FERMT3,ARHGAP26 All fusions
Proteins found in more fusions SNRNP200 (see 2 fusions); APP (see 5 fusions); PTK2 (see 3 fusions); PRDX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FERMT3parental protein330.0491340.655FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
2 ARHGAP26parental protein90.083353.871Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BAR_3 (PF16746): BAR domain of APPL family
3 ACADSinteractor100Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ALKBH2interactor1002OG-FeII_Oxy_2 (PF13532, IPR027450): 2OG-Fe(II) oxygenase superfamily
5 APPprotein found in more fusions90.250157.452APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 C2CD2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057)
7 CDC42oncoprotein40.33396.760Ras (PF00071, IPR001806, SM00173): Ras family
8 CDC42EP2interactor21.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
BORG_CEP (PF14957, IPR029273): Cdc42 effector
9 COX5Ainteractor100COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
10 EIF4E2interactor21.0000IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
11 EXOSC10interactor21.0000DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
12 FN1oncoprotein70.42925.767fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
13 FYTTD1interactor200FYTT (PF07078, IPR009782): Forty-two-three protein
14 ITGA4interactor80.52487.743FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
15 KANSL2interactor21.0000WRC (PF08879, IPR014977): WRC
zf-C3Hc3H (PF13891, IPR025927): Potential DNA-binding domain
16 KEAP1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
17 KLHL7interactor200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_6 (PF13964): Kelch motif
18 LSM8interactor40.5002.667LSM (PF01423, IPR001163): LSM domain
19 MRPS27interactor100MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
20 NCBP1interactor40.5003.000MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
MIF4G_like (PF09088, IPR015172): MIF4G like
MIF4G_like_2 (PF09090, IPR015174): MIF4G like
SlyX (PF04102, IPR007236): SlyX
21 PARVBoncoprotein1004HBT (PF03061, IPR006683): Thioesterase superfamily
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
22 PDCD6oncoprotein50.8330.400EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 PKN3interactor100HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
24 PKP4interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
25 POLDIP3interactor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 PRDX1oncoprotein80.286247.848AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
27 PRDX5interactor30.6671.786Redoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
28 PTENsuppressor30.33343.845DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
29 PTK2protein found in more fusions70.200205.410FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
30 RBBP5oncoprotein200WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 RHOAsuppressor100Ras (PF00071, IPR001806, SM00173): Ras family
32 SNIP1interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
FAM176 (PF14851): FAM176 family
33 SNRNP200protein found in more fusions60.6004.817DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
34 SPENoncoprotein100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
SPOC (PF07744, IPR012921): SPOC domain
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
35 SRPK1interactor40.50093.214FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
36 STXBP1interactor21.0000Sec1 (PF00995, IPR001619): Sec1 family
37 TAF1Binteractor30.66749.393Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
38 TBC1D10Ainteractor100LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
TonB_N (PF16031): TonB N-terminal region
39 TINF2interactor31.0000TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
40 TRIM15suppressor50.33368.607Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
41 UHRF1BP1Loncoprotein100Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
42 USP15oncoprotein40.6670.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
43 VCAM1interactor50.7004.100C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
44 ZC3H18interactor100FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Miga (PF10265, IPR019392): Mitoguardin
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
LRR19-TM (PF15176): Leucine-rich repeat family 19 TM domain

B a c k    t o    T o p ⇑