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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAM110A, HECTD3 (from a repository: Mon Jul 29 12:14:37 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins12 (26.67 %)
The number (and %) of the tumor suppressors6 (13.33 %)
Total number of binary PPIs (saturation %)109 (11.01 %)
The number (and %) of affected PPIs43 (39.45 %)
The number of possible different fusions7
PPI diameter5
PPI radius3
The average degree of PPI4.000
Assortativity coefficient-0.3344
The network average Clustering coefficient0.430
The number (and %) of a zero Clustering coefficients14 (31.11 %)
The number (and %) of a zero Betweenness Centrality21 (46.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: HECTD3,FAM110A All fusions
Proteins found in more fusions HSP90AA1 (see 6 fusions); MAVS (see 1 fusions); MALT1 (see 1 fusions); ZDHHC17 (see 2 fusions); MYC (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 HECTD3parental protein260.092920.482ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
2 FAM110Aparental protein170.051799.065FAM110_C (PF14160, IPR025741): Centrosome-associated C terminus
FAM110_N (PF14161, IPR025739): Centrosome-associated N terminus
3 BRCA1suppressor60.70012.400BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
4 CASP8suppressor31.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
5 CCDC130interactor21.0000DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
6 CCNDBP1suppressor100CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
7 CCNG1oncoprotein40.33396.567Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
8 CDR2interactor40.33368.916DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
9 CSNK1Einteractor50.333174.475APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
10 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
11 FOSL2oncoprotein30.6671.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
12 GOLGA2interactor40194.944ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
13 HSP90AA1oncoprotein70.7334.406HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
14 KRT15interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
15 KRT31interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
16 MALT1oncoprotein200Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
17 MAVSprotein found in more fusions200Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
CARD_2 (PF16739, IPR031964): Caspase recruitment domain
18 MKRN3oncoprotein31.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
19 MRM1interactor21.0000SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
20 MTUS2suppressor200DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
21 MYConcoprotein80.476154.948HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
22 NCAPHinteractor30.6671.000Cnd2 (PF05786, IPR022816): Condensin complex subunit 2
23 NTRK1oncoprotein110.200264.398I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
24 PARD6Binteractor30.33361.981PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
25 PNMA1oncoprotein2072.314PNMA (PF14893, IPR026523): PNMA
26 POGLUT1interactor21.0000Glyco_transf_90 (PF05686, IPR006598, SM00672): Glycosyl transferase family 90
27 RINT1suppressor2061.199RINT1_TIP1 (PF04437, IPR007528): RINT-1 / TIP-1 family
28 RPS4Xinteractor50.6004.491KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
29 RSPO1oncoprotein21.0000TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Furin-like_2 (PF15913, IPR006212): Furin-like repeat, cysteine-rich
30 SCCPDHinteractor30.6671.000Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
31 STX11interactor31.0000KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
32 STX8interactor100CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
SNARE (PF05739, IPR000727, SM00397): SNARE domain
HD_assoc (PF13286, IPR026875): Phosphohydrolase-associated domain
33 TP53suppressor110.267227.500DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
34 TRIM23interactor50.50010.940Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
35 TRIM27oncoprotein40.33396.223IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
36 TRIM54interactor31.0000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
37 TRIM69interactor200DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
38 TRIOBPinteractor100FadA (PF09403, IPR018543): Adhesion protein FadA
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PH (PF00169, IPR001849, SM00233): PH domain
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
39 TRMT10Cinteractor40.5003.491tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
PPR_2 (PF13041, IPR002885): PPR repeat family
40 UBXN10interactor100UBX (PF00789, IPR001012, SM00166): UBX domain
41 USHBP1interactor60.4006.000DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
42 WNT9Binteractor21.0000wnt (PF00110, IPR005817, SM00097): wnt family
43 ZDHHC17protein found in more fusions3034.898zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
44 ZNF317interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
45 ZZEF1interactor130.15497.362ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
CUB (PF00431, IPR000859, SM00042): CUB domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair

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