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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins24 (39.34 %)
The number (and %) of the tumor suppressors7 (11.48 %)
Total number of binary PPIs (saturation %)144 (7.87 %)
The number (and %) of affected PPIs60 (41.67 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI3.902
Assortativity coefficient-0.3786
The network average Clustering coefficient0.410
The number (and %) of a zero Clustering coefficients26 (42.62 %)
The number (and %) of a zero Betweenness Centrality37 (60.66 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions FTL (see 3 fusions); LGALS3 (see 2 fusions); ACTG1/ACTB (see 1 fusions); TPM1 (see 2 fusions); A2M (see 2 fusions); ACTB (see 3 fusions); TKT (see 5 fusions); CSNK1E (see 1 fusions); ACTG1 (see 4 fusions); EEF1A1 (see 1 fusions); TNFRSF1A (see 2 fusions); GAPDH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MYOCparental protein430.0552260.690IncA (PF04156, IPR007285): IncA protein
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
2 FAM110Aparental protein170.0511187.833FAM110_C (PF14160, IPR025741): Centrosome-associated C terminus
FAM110_N (PF14161, IPR025739): Centrosome-associated N terminus
3 A2Mprotein found in more fusions31.0000A2M (PF00207, IPR001599): Alpha-2-macroglobulin family
A2M_comp (PF07678, IPR011626): A-macroglobulin complement component
A2M_N (PF01835, IPR002890): MG2 domain
A2M_N_2 (PF07703, IPR011625): Alpha-2-macroglobulin family N-terminal region
A2M_recep (PF07677, IPR009048): A-macroglobulin receptor
MP (PF01107, IPR028919): Viral movement protein (MP)
SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
Thiol-ester_cl (PF10569, IPR019565): Alpha-macro-globulin thiol-ester bond-forming region
4 ACTA2interactor50.300119.943Actin (PF00022, IPR004000, SM00268): Actin
5 ACTBoncoprotein90.357216.676Actin (PF00022, IPR004000, SM00268): Actin
6 ACTG1protein found in more fusions60.8001.833Actin (PF00022, IPR004000, SM00268): Actin
7 ALDOAinteractor70.9330.400Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 ANXA2interactor31.0000Annexin (PF00191, IPR018502, SM00335): Annexin
9 C1QBinteractor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
10 CAP1interactor41.0000CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
11 CCNDBP1suppressor100CheF-arch (PF04283, IPR007381): Chemotaxis signal transduction system protein F from archaea
GCIP (PF13324): Grap2 and cyclin-D-interacting
12 CD81interactor70.6673.967Tetraspannin (PF00335, IPR018499): Tetraspanin family
13 CDR2interactor31.0000DivIC (PF04977, IPR007060): Septum formation initiator
SlyX (PF04102, IPR007236): SlyX
Striatin (PF08232, IPR013258): Striatin family
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
14 CKMinteractor100ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
15 CLIC1interactor21.0000GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
16 COL1A2oncoprotein100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
17 COL3A1oncoprotein100COLFI (PF01410, IPR000885, SM00038): Fibrillar collagen C-terminal domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
18 CSNK1Eprotein found in more fusions200APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
19 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
20 ECE1interactor21.0000Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
21 EEF1A1suppressor80.7144.467GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
22 ENO1oncoprotein51.0000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
23 FBN1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TB (PF00683, IPR017878): TB domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
24 FN1oncoprotein170.250558.843fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
25 FTLprotein found in more fusions30285.976Ferritin (PF00210, IPR008331): Ferritin-like domain
26 FUBP1oncoprotein60.6004.667DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897)
KH_1 (PF00013, IPR004088, SM00322): KH domain
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
27 GAPDHoncoprotein90.7145.067Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
28 GOLGA2interactor30263.262ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
29 HAGHinteractor100Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
Lactamase_B_2 (PF12706, IPR001279): Beta-lactamase superfamily domain
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
30 HSPA4interactor21.0000Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
31 IGKConcoprotein100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
32 IGLL1interactor100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
33 ITGA7suppressor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
34 KRT15interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
35 KRT31interactor30.333415.476Filament (PF00038, IPR001664): Intermediate filament protein
36 LAMA5interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_2 (PF02210, IPR001791): Laminin G domain
Laminin_I (PF06008, IPR009254): Laminin Domain I
Laminin_II (PF06009, IPR010307): Laminin Domain II
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Laminin_N (PF00055, IPR008211, SM00136): Laminin N-terminal (Domain VI)
37 LGALS3oncoprotein70.333160.976Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
38 MAEAinteractor100Mic1 (PF07035, IPR009755): Colon cancer-associated protein Mic1-like
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
39 MKRN3oncoprotein31.0000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-3CxxC_2 (PF17180): Zinc-binding domain
40 MTUS2suppressor200DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
41 MYH11oncoprotein30.6670.667IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
42 NOTCH2suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
43 OLFM3interactor100Dynactin_p22 (PF07426, IPR009991): Dynactin subunit p22
OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
Helo_like_N (PF17111, IPR031348): Fungal N-terminal domain of STAND proteins
44 OLFML3interactor100OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
45 PKMoncoprotein80.6795.333PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
46 PNMA1oncoprotein30298.786PNMA (PF14893, IPR026523): PNMA
47 RFC1interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
RFC1 (PF08519, IPR013725): Replication factor RFC1 C terminal domain
DUF2316 (PF10078, IPR018757): Uncharacterized protein conserved in bacteria (DUF2316)
48 RINT1suppressor100RINT1_TIP1 (PF04437, IPR007528): RINT-1 / TIP-1 family
49 SERPINF1oncoprotein100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
50 STX11interactor31.0000KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
51 TGFBR1oncoprotein30.6674.810Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
52 TIMP1oncoprotein100TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
53 TKTprotein found in more fusions70.9330.400Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
54 TNFRSF1Aoncoprotein200Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
55 TPM1protein found in more fusions50.333133.286Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
56 TRIM23interactor50.5003.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
57 TRIM27oncoprotein31.0000IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
58 TRIM54interactor31.0000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
zf-HIT (PF04438, IPR007529): HIT zinc finger
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
59 TRIM69interactor200DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
60 USHBP1interactor70.267286.476DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
61 VIMsuppressor50.8331.167Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region

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