Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DRC3, ATPAF2 (from a repository: Fri Jul 26 20:32:02 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins10 (33.33 %)
The number (and %) of the tumor suppressors3 (10.00 %)
Total number of binary PPIs (saturation %)58 (13.33 %)
The number (and %) of affected PPIs28 (48.28 %)
The number of possible different fusions8
PPI diameter2
PPI radiusinf
The average degree of PPI2.933
Assortativity coefficient-0.4663
The network average Clustering coefficient0.415
The number (and %) of a zero Clustering coefficients13 (43.33 %)
The number (and %) of a zero Betweenness Centrality20 (66.67 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ATPAF2,DRC3 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); APP (see 5 fusions); ECHS1 (see 1 fusions); SORBS2 (see 4 fusions); EBF1 (see 1 fusions); ATP5A1 (see 1 fusions); LNX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ATPAF2parental protein280.042700.000ATP12 (PF07542, IPR011419): ATP12 chaperone protein
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
2 DRC3interactor000Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
MIEAP (PF16026, IPR031981): Mitochondria-eating protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
3 APPprotein found in more fusions40.6671.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ATP5A1protein found in more fusions50.5003.000ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
5 ATP5Binteractor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
6 DDIT3oncoprotein200IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
7 EBF1oncoprotein200TIG (PF01833, IPR002909): IPT/TIG domain
COE1_DBD (PF16422, IPR032200): Transcription factor COE1 DNA-binding domain
COE1_HLH (PF16423, IPR032201): Transcription factor COE1 helix-loop-helix domain
8 ECHS1protein found in more fusions200ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
9 EWSR1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 FMC1interactor30.6671.000Complex1_LYR_2 (PF13233): Complex1_LYR-like
11 IKZF3suppressor31.0000C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
12 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
13 LNX1protein found in more fusions70.4009.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
14 LRRFIP2interactor100TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
LRRFIP (PF09738, IPR019139): LRRFIP family
15 LZTS2suppressor30.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
16 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
17 MRM1interactor100SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
18 NDUFAB1interactor30.6671.000MinE (PF03776, IPR005527): Septum formation topological specificity factor MinE
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
19 OXLD1interactor21.0000Oxidored-like (PF09791, IPR019180): Oxidoreductase-like protein, N-terminal
20 PAK5interactor31.0000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
21 PKP4interactor40.6672.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
22 PRDM14interactor100Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
23 RAD54Binteractor31.0000SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HDA2-3 (PF11496, IPR021006): Class II histone deacetylase complex subunits 2 and 3
24 RELoncoprotein100RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
25 RPIAinteractor31.0000Rib_5-P_isom_A (PF06026, IPR004788): Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Sugar-bind (PF04198, IPR007324): Putative sugar-binding domain
26 SORBS2oncoprotein200Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 SPG21interactor30.6671.000Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
28 TP53BP2suppressor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Erp_C (PF06780, IPR009618): Erp protein C-terminus
SlyX (PF04102, IPR007236): SlyX
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
29 TRIM23interactor60.5005.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
30 TRIM27oncoprotein31.0000IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease

B a c k    t o    T o p ⇑