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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins HIST1H2BN, SHMT1 (from a repository: Sun Oct 13 06:18:55 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins14 (24.56 %)
The number (and %) of the tumor suppressors7 (12.28 %)
Total number of binary PPIs (saturation %)193 (12.09 %)
The number (and %) of affected PPIs56 (29.02 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI6.105
Assortativity coefficient-0.3649
The network average Clustering coefficient0.381
The number (and %) of a zero Clustering coefficients17 (29.82 %)
The number (and %) of a zero Betweenness Centrality16 (28.07 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SHMT1,HIST1H2BN All fusions
Proteins found in more fusions CUL7 (see 2 fusions); APEH (see 1 fusions); EWSR1 (see 1 fusions); SMAD4 (see 3 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); MAPK9 (see 3 fusions); ITPA (see 1 fusions); MCM2 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SHMT1parental protein420.0961710.265SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2 HIST1H2BNparental protein140.165501.540Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
3 APEHoncoprotein90.6436.249Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
4 ARFIP1interactor50.7007.051Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5 ASB16interactor2011.053Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
6 ASB9interactor2011.053Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
7 ATIConcoprotein30.33316.116AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
8 ATP6V1C1protein found in more fusions130.62118.496V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
9 BCCIPinteractor100DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
10 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
11 CARSoncoprotein80.46425.109tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
12 CD81interactor60.7008.156Tetraspannin (PF00335, IPR018499): Tetraspanin family
13 CTTNoncoprotein120.47397.651FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14 CUL7protein found in more fusions70.33377.520ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
15 DEDDinteractor200DED (PF01335, IPR001875, SM00031): Death effector domain
16 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
17 EWSR1oncoprotein120.200182.131RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 FAM129Binteractor60.9330.333PH (PF00169, IPR001849, SM00233): PH domain
19 GARSinteractor70.57110.658HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
20 GSPT2interactor70.9050.801GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
21 GTF2F2interactor2013.232TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
22 HARSinteractor60.46721.013HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
23 HIST1H4Ainteractor120.197342.063CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
24 HSPA1Linteractor30.33336.690HSP70 (PF00012, IPR013126): Hsp70 protein
25 HSPE1interactor60.26764.728Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
26 ICAM1oncoprotein100Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
27 IDEinteractor90.6676.895Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
28 IGSF8oncoprotein31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
29 ING4suppressor200PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
30 ITGA4interactor90.39382.438FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
31 ITPAprotein found in more fusions31.0000Ham1p_like (PF01725, IPR002637): Ham1 family
32 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
33 MCATinteractor2013.232Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
34 MCM2oncoprotein110.289123.989AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
35 MCM5oncoprotein90.361185.458MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
36 OBSL1interactor100.361120.418BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
37 PAICSinteractor60.30020.861AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
38 PAWRsuppressor110.61814.426ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
39 PBDC1interactor100Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
40 PGK2interactor21.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
41 PIM1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
42 PPATinteractor30.6670.667Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
43 PRRC1interactor40.50015.886NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
44 PRSS23interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
45 SHMT2interactor150.343158.560SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
46 SMAD4suppressor40.33314.782MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
47 SNX2interactor110.58223.574PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
48 SNX6interactor110.60023.547PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
49 SPRTNinteractor100GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
50 STAT1suppressor130.591122.244SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
51 STXBP1interactor100Sec1 (PF00995, IPR001619): Sec1 family
52 SULT1A3interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
53 TSNprotein found in more fusions70.9330.333Translin (PF01997, IPR002848): Translin family
54 TTC1interactor70.52411.250TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
55 VPS29interactor80.8573.408Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
56 XPO5suppressor50.40026.886IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
57 ZC3H4interactor2011.235API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain

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