Find Fusion Network

Enter

Fusion ID: Protein names:	8341 6470
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:

all

affected

independent (normal)

nothing (blank)

Visualization interactions

Cytoscape Web for: parental proteins HIST1H2BN, SHMT1 (from a repository: Sun Oct 13 06:18:55 2019)

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	57
The number (and %) of the onco-proteins	14 (24.56 %)
The number (and %) of the tumor suppressors	7 (12.28 %)
Total number of binary PPIs (saturation %)	193 (12.09 %)
The number (and %) of affected PPIs	56 (29.02 %)
The number of possible different fusions	12
PPI diameter	5
PPI radius	3
The average degree of PPI	6.105
Assortativity coefficient	-0.3649
The network average Clustering coefficient	0.381
The number (and %) of a zero Clustering coefficients	17 (29.82 %)
The number (and %) of a zero Betweenness Centrality	16 (28.07 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SHMT1,HIST1H2BN	All fusions
Proteins found in more fusions	CUL7 (see 2 fusions); APEH (see 1 fusions); EWSR1 (see 1 fusions); SMAD4 (see 3 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); MAPK9 (see 3 fusions); ITPA (see 1 fusions); MCM2 (see 1 fusions); STAT1 (see 1 fusions); CTTN (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SHMT1	parental protein	42	0.096	1710.265	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2	HIST1H2BN	parental protein	14	0.165	501.540	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
3	APEH	oncoprotein	9	0.643	6.249	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
4	ARFIP1	interactor	5	0.700	7.051	Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
5	ASB16	interactor	2	0	11.053	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
6	ASB9	interactor	2	0	11.053	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
7	ATIC	oncoprotein	3	0.333	16.116	AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme MGS (PF02142, IPR011607, SM00851): MGS-like domain
8	ATP6V1C1	protein found in more fusions	13	0.621	18.496	V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
9	BCCIP	interactor	1	0	0	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi BCIP (PF13862, IPR025602): p21-C-terminal region-binding protein
10	C18orf25	interactor	1	0	0	RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
11	CARS	oncoprotein	8	0.464	25.109	tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
12	CD81	interactor	6	0.700	8.156	Tetraspannin (PF00335, IPR018499): Tetraspanin family
13	CTTN	oncoprotein	12	0.473	97.651	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14	CUL7	protein found in more fusions	7	0.333	77.520	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
15	DEDD	interactor	2	0	0	DED (PF01335, IPR001875, SM00031): Death effector domain
16	DLEU1	suppressor	1	0	0	DD_K (PF12121, IPR022731): Dermaseptin
17	EWSR1	oncoprotein	12	0.200	182.131	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
18	FAM129B	interactor	6	0.933	0.333	PH (PF00169, IPR001849, SM00233): PH domain
19	GARS	interactor	7	0.571	10.658	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
20	GSPT2	interactor	7	0.905	0.801	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
21	GTF2F2	interactor	2	0	13.232	TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
22	HARS	interactor	6	0.467	21.013	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
23	HIST1H4A	interactor	12	0.197	342.063	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
24	HSPA1L	interactor	3	0.333	36.690	HSP70 (PF00012, IPR013126): Hsp70 protein
25	HSPE1	interactor	6	0.267	64.728	Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
26	ICAM1	oncoprotein	1	0	0	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
27	IDE	interactor	9	0.667	6.895	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
28	IGSF8	oncoprotein	3	1.000	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
29	ING4	suppressor	2	0	0	PHD (PF00628, IPR019787, SM00249): PHD-finger SOGA (PF11365, IPR027881): Protein SOGA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
30	ITGA4	interactor	9	0.393	82.438	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
31	ITPA	protein found in more fusions	3	1.000	0	Ham1p_like (PF01725, IPR002637): Ham1 family
32	MAPK9	suppressor	2	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like
33	MCAT	interactor	2	0	13.232	Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
34	MCM2	oncoprotein	11	0.289	123.989	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
35	MCM5	oncoprotein	9	0.361	185.458	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
36	OBSL1	interactor	10	0.361	120.418	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
37	PAICS	interactor	6	0.300	20.861	AIRC (PF00731, IPR000031, SM01001): AIR carboxylase SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
38	PAWR	suppressor	11	0.618	14.426	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
39	PBDC1	interactor	1	0	0	Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
40	PGK2	interactor	2	1.000	0	PGK (PF00162, IPR001576): Phosphoglycerate kinase
41	PIM1	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
42	PPAT	interactor	3	0.667	0.667	Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain GATase_6 (PF13522): Glutamine amidotransferase domain
43	PRRC1	interactor	4	0.500	15.886	NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
44	PRSS23	interactor	1	0	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
45	SHMT2	interactor	15	0.343	158.560	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
46	SMAD4	suppressor	4	0.333	14.782	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
47	SNX2	interactor	11	0.582	23.574	PX (PF00787, IPR001683, SM00312): PX domain Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
48	SNX6	interactor	11	0.600	23.547	PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
49	SPRTN	interactor	1	0	0	GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term SprT-like (PF10263, IPR006640, SM00731): SprT-like family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
50	STAT1	suppressor	13	0.591	122.244	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
51	STXBP1	interactor	1	0	0	Sec1 (PF00995, IPR001619): Sec1 family
52	SULT1A3	interactor	1	0	0	Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
53	TSN	protein found in more fusions	7	0.933	0.333	Translin (PF01997, IPR002848): Translin family
54	TTC1	interactor	7	0.524	11.250	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
55	VPS29	interactor	8	0.857	3.408	Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
56	XPO5	suppressor	5	0.400	26.886	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
57	ZC3H4	interactor	2	0	11.235	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal Metal_resist (PF13801, IPR025961): Heavy-metal resistance Torus (PF16131, IPR032297): Torus domain

B a c k t o T o p ⇑

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors