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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins RAP2C, SLIRP (from a repository: Wed Feb 7 10:52:04 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins11 (23.91 %)
The number (and %) of the tumor suppressors3 (6.52 %)
Total number of binary PPIs (saturation %)104 (10.05 %)
The number (and %) of affected PPIs46 (44.23 %)
The number of possible different fusions5
PPI diameter4
PPI radius2
The average degree of PPI4.087
Assortativity coefficient-0.3039
The network average Clustering coefficient0.454
The number (and %) of a zero Clustering coefficients12 (26.09 %)
The number (and %) of a zero Betweenness Centrality19 (41.30 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SLIRP,RAP2C All fusions
Proteins found in more fusions VCP (see 4 fusions); CSNK2A1 (see 1 fusions); CSNK2A1/ELAVL1 (see 1 fusions); U2AF2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SLIRPparental protein380.0541584.884RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
2 RAP2Cparental protein80.107126.402Ras (PF00071, IPR001806, SM00173): Ras family
3 ADRB2interactor60.30054.0457tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
4 ASB5interactor30.66732.829Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
5 BABAM1interactor2062.500VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
6 CCDC102Binteractor200Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
7 CCT6Ainteractor40.16723.195Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CSNK2A1oncoprotein50.6672.794Pkinase (PF00069, IPR000719): Protein kinase domain
9 DDX39Ainteractor308.000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
10 DSTNinteractor21.0000Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
11 ECHDC2interactor100ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 EID1interactor100NA
13 EIF4G2interactor100MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
14 ELAVL1oncoprotein80.381113.973RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
15 ESRRBsuppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
16 FHL3interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Med27 (PF11571, IPR021627): Mediator complex subunit 27
17 HAUS2interactor40.5006.067DpnII (PF04556, IPR007637): DpnII restriction endonuclease
HAUS2 (PF15003, IPR028346): HAUS augmin-like complex subunit 2
18 HNRNPA2B1oncoprotein50.6002.917RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 HNRNPRinteractor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
20 ILF3oncoprotein70.47613.970dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
21 KRT40interactor100Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
22 LIMA1suppressor21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
23 LRPPRCinteractor80.25082.713DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
24 MRPL58interactor30.6672.167RF-1 (PF00472, IPR000352): RF-1 domain
25 MRRFinteractor30.6671.000RRF (PF01765, IPR023584): Ribosome recycling factor
YtxH (PF12732, IPR024623): YtxH-like protein
26 MTUS2suppressor31.0000DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
27 PIN4interactor21.0000Rotamase_3 (PF13616): PPIC-type PPIASE domain
28 PNMA1oncoprotein21.0000PNMA (PF14893, IPR026523): PNMA
29 PPIFinteractor30.6671.000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
30 PQBP1interactor21.0000WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
31 RAB1Aoncoprotein60.26799.839Ras (PF00071, IPR001806, SM00173): Ras family
32 RAB1Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
33 RBM8Ainteractor200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34 RFX5oncoprotein100RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain
35 RPL38interactor30.33363.233Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
36 RPS10interactor208.300S10_plectin (PF03501, IPR005326): Plectin/S10 domain
37 SBDSoncoprotein100SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
38 SCAMP3interactor30.6671.000SCAMP (PF04144, IPR007273): SCAMP family
39 SF3B4interactor30.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40 SLX1Binteractor100GIY-YIG (PF01541, IPR000305, SM00465): GIY-YIG catalytic domain
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
41 SNRNP70interactor60.6005.083RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
42 SNRPCinteractor40.6671.667zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
43 SUGP1interactor50.4007.500G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
44 U2AF2protein found in more fusions100.36152.196RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
45 VCPprotein found in more fusions70.40027.383AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
46 WDR83interactor40.33322.679WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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