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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)131
The number (and %) of the onco-proteins30 (22.90 %)
The number (and %) of the tumor suppressors19 (14.50 %)
Total number of binary PPIs (saturation %)571 (6.71 %)
The number (and %) of affected PPIs130 (22.77 %)
The number of possible different fusions24
PPI diameter4
PPI radius2
The average degree of PPI7.924
Assortativity coefficient-0.3278
The network average Clustering coefficient0.461
The number (and %) of a zero Clustering coefficients18 (13.74 %)
The number (and %) of a zero Betweenness Centrality32 (24.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAP1LC3B,BCL2L11 All fusions
Proteins found in more fusions APP (see 4 fusions); MCL1 (see 2 fusions); LUC7L2 (see 2 fusions); GABARAP (see 2 fusions); CUL3 (see 1 fusions); SQSTM1 (see 5 fusions); SHFM1/BAG3 (see 1 fusions); SMARCB1 (see 12 fusions); VHL (see 1 fusions); OPTN (see 1 fusions); BAG3 (see 4 fusions); BCL2L1 (see 1 fusions); ULK1 (see 2 fusions); CLINT1 (see 2 fusions); UBQLN2 (see 2 fusions); RACK1 (see 3 fusions); MYBL2 (see 4 fusions); EPS8 (see 1 fusions); PML (see 4 fusions); STK3 (see 1 fusions); RASSF5 (see 2 fusions); TP53 (see 3 fusions); THAP7 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAP1LC3Bparental protein870.0537397.584Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
2 BCL2L11parental protein430.0763751.918Bclx_interact (PF08945, IPR015040): Bcl-x interacting, BH3 domain
Bim_N (PF06773, IPR014771): Bim protein N-terminus
3 AAMPinteractor21.0000PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 ADD1interactor21.0000Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
5 ADNPinteractor40.66723.479zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
PHD_Oberon (PF07227, IPR032881): PHD - plant homeodomain finger protein
E6 (PF00518, IPR001334): Early Protein (E6)
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
6 ADRB2interactor80.286116.0657tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 ANKLE2interactor21.0000Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
8 APPprotein found in more fusions310.0901427.739APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
9 ARFGAP1interactor40.50024.794ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
10 ATG13oncoprotein70.61912.959ATG13 (PF10033, IPR018731): Autophagy-related protein 13
11 ATG16L1interactor80.38134.521ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
12 ATG3interactor100.42228.055Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
13 ATG4Ainteractor21.0000Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
14 ATG4Binteractor110.47353.494Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
15 ATG5interactor50.40023.095APG5 (PF04106, IPR007239): Autophagy protein Apg5
16 ATG7interactor80.57123.659ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
17 ATP2A3interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
18 ATP6V1G1interactor21.0000V-ATPase_G (PF03179): Vacuolar (H+)-ATPase G subunit
19 AURKAoncoprotein100.30691.322Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
20 AURKBinteractor110.244121.102Pkinase (PF00069, IPR000719): Protein kinase domain
21 BAG3oncoprotein180.213290.960BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
22 BAXsuppressor140.39782.950Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
23 BCL2oncoprotein170.283303.825Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
24 BCL2A1oncoprotein30.6672.429Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
25 BCL2L1oncoprotein140.346159.561Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
26 BCL2L2oncoprotein30.6675.344Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator
27 BNIP3oncoprotein60.50031.249BNIP3 (PF06553, IPR010548): BNIP3
28 BNIP3Lsuppressor80.38158.408BNIP3 (PF06553, IPR010548): BNIP3
29 BRD3oncoprotein205.002DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
IncA (PF04156, IPR007285): IncA protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
30 BTKsuppressor60.20074.871BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
31 BTRConcoprotein160.190288.615WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
32 CACNA1Binteractor30.6671.111Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ion_trans (PF00520, IPR005821): Ion transport protein
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
33 CALCOCO2interactor80.6672.571bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
34 CASP8suppressor110.444117.898DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
35 CCSER2interactor205.002NA
36 CD302interactor100UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
37 CISHinteractor41.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
SOCS_box (PF07525, IPR001496): SOCS box
38 CLINT1protein found in more fusions70.26755.877ENTH (PF01417, IPR001026, SM00273): ENTH domain
39 CLTAinteractor60.40020.789Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
40 CUL2suppressor150.200439.597Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
41 CUL3protein found in more fusions290.143828.061Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
42 DBIinteractor21.0000ACBP (PF00887, IPR000582): Acyl CoA binding protein
JmjN (PF02375, IPR003349, SM00545): jmjN domain
43 DBN1oncoprotein70.28682.295Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
44 DCTN1interactor50.33334.641Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
45 DNMT3Bsuppressor50.50019.985DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
46 DOCK1interactor30.33311.548DHR-2 (PF06920, IPR010703): Dock homology region 2
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TetR_C_8 (PF14278): Transcriptional regulator C-terminal region
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DOCK_N (PF16172, IPR032376): DOCK N-terminus
47 DYNLL1interactor100.194149.923Dynein_light (PF01221, IPR001372): Dynein light chain type 1
48 DYNLL2interactor40.66715.946Dynein_light (PF01221, IPR001372): Dynein light chain type 1
49 EDNRAinteractor21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
50 EEDsuppressor120.200267.351WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
51 EPS8oncoprotein200DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
52 FAM134Ainteractor100INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
Reticulon (PF02453, IPR003388): Reticulon
53 FAM65Ainteractor100NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
PL48 (PF15903, IPR031780): Filopodia upregulated, FAM65
54 FBXW11interactor170.225286.843WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
55 FEM1Cinteractor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
TPR_12 (PF13424): Tetratricopeptide repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
56 FGL1interactor21.0000Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
57 FLCNsuppressor70.28647.014Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
Folliculin_C (PF16692, IPR032035): Folliculin C-terminal domain
58 FUNDC1interactor30.6670.126FUN14 (PF04930, IPR007014): FUN14 family
59 FYCO1interactor30.6675.002Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RUN (PF02759, IPR004012, SM00593): RUN domain
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
60 GABARAPsuppressor240.265148.885Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
61 GABARAPL2interactor360.151772.051Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
62 GBASinteractor100.7117.871NIPSNAP (PF07978, IPR012577): NIPSNAP
63 GIMAP5interactor50.7007.171AIG1 (PF04548, IPR006703): AIG1 family
KapB (PF08810, IPR014916): Kinase associated protein B
64 GORASP2interactor50.30029.163GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
65 GTF2Iinteractor70.23866.772GTF2I (PF02946, IPR004212): GTF2I-like repeat
66 HADHAinteractor70.61952.0663HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
67 HADHBinteractor70.57110.926Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
68 HDAC1suppressor150.209182.833FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
69 HSPA4interactor130.269195.894Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
70 KBTBD6interactor51.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
71 KBTBD7interactor60.8003.160BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
72 KEAP1oncoprotein150.319182.230BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
73 KIF22interactor100Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
HHH_3 (PF12836): Helix-hairpin-helix motif
74 KLHL5interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
75 KXD1interactor21.0000KxDL (PF10241, IPR019371): Uncharacterized conserved protein
76 LUC7L2protein found in more fusions50.50015.274LUC7 (PF03194, IPR004882): LUC7 N_terminus
Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein
Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
77 MAGEA11interactor200MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
78 MAP1Ainteractor30.6671.355Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
Lactamase_B_6 (PF16661, IPR001279): Metallo-beta-lactamase superfamily domain
79 MAP1Binteractor100.37853.131DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
Striatin (PF08232, IPR013258): Striatin family
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
80 MAP1LC3Ainteractor380.111722.994Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
81 MAPK15interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
82 MAPK8oncoprotein100.30692.830DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
83 MCL1oncoprotein100.50077.074Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
84 MKRN1interactor30.6673.197Opy2 (PF09463, IPR018571): Opy2 protein
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
CD52 (PF15116, IPR026643): CAMPATH-1 antigen
MKRN1_C (PF15815, IPR031644): E3 ubiquitin-protein ligase makorin-1, C-terminal
Torus (PF16131, IPR032297): Torus domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
85 MRFAP1interactor100MRFAP1 (PF15155, IPR029254): MORF4 family-associated protein1
86 MTHFRoncoprotein100MTHFR (PF02219, IPR003171): Methylenetetrahydrofolate reductase
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
87 MYBL2oncoprotein31.0000Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
88 NBR1oncoprotein60.8000.251CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
89 NDRG1suppressor50.20051.129Ndr (PF03096, IPR004142): Ndr family
90 NIPSNAP1interactor80.67910.367NIPSNAP (PF07978, IPR012577): NIPSNAP
91 OPTNprotein found in more fusions110.48939.124ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
92 PMLsuppressor70.53333.612zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
93 PRKCIinteractor90.55650.905PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
94 RACK1suppressor110.378132.926WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
95 RAP1GAPsuppressor30.33311.548GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
96 RASSF5suppressor70.8009.917RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
97 RHPN2interactor100BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
98 RIOK3interactor21.0000RIO1 (PF01163, IPR018934): RIO1 family
99 RPLP1interactor50.66714.770Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
100 SAFBsuppressor50.4005.842RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SAP (PF02037, IPR003034, SM00513): SAP domain
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
101 SHFM1protein found in more fusions4073.849CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
102 SMARCB1suppressor70.400366.938SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
103 SNU13interactor31.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
104 SPAG9interactor3052.180DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IncA (PF04156, IPR007285): IncA protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
105 SQSTM1oncoprotein270.280439.116PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
106 STK3protein found in more fusions110.48952.052Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
107 STK4oncoprotein100.55640.415Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
108 TAF7interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ELM2 (PF01448, IPR000949): ELM2 domain
TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
XhlA (PF10779, IPR019715): Haemolysin XhlA
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
109 TAX1BP1interactor80.6435.965CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
110 TBC1D17interactor50.50034.672RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
111 TBC1D25interactor40.6670.251RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
112 TBC1D5interactor40.33312.233RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
113 TBC1D9interactor30.6670.126GRAM (PF02893, IPR004182, SM00568): GRAM domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
114 TBC1D9Binteractor40.6675.128GRAM (PF02893, IPR004182, SM00568): GRAM domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
115 TBK1interactor90.39361.461DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
116 TCEB2interactor60.73325.144ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117 THAP7protein found in more fusions305.002THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
118 TMEM160interactor50.7001.986Borrelia_P13 (PF05628, IPR008420): Borrelia membrane protein P13
DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
119 TMOD3interactor21.0000Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
120 TNIP1interactor70.7331.299ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
121 TP53suppressor270.154842.173DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
122 TRIM2interactor100Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
NHL (PF01436, IPR001258): NHL repeat
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
Caskin-tail (PF16632, IPR032117): C-terminal region of Caskin
DUF5128 (PF17170): 6-bladed beta-propeller
123 TRIM21interactor100.41726.306DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
124 UBE2L3interactor70.20061.646UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
125 UBQLN2protein found in more fusions4019.940Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
126 ULK1protein found in more fusions110.57810.083Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
127 UPF2interactor31.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
128 USP27Xinteractor100UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ISG65-75 (PF11727, IPR021057): Invariant surface glycoprotein
129 VDAC1interactor80.464137.261Porin_3 (PF01459, IPR027246): Eukaryotic porin
130 VHLsuppressor120.327111.071Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
131 YWHABinteractor110.273173.85614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor

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