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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)149
The number (and %) of the onco-proteins49 (32.89 %)
The number (and %) of the tumor suppressors12 (8.05 %)
Total number of binary PPIs (saturation %)953 (8.64 %)
The number (and %) of affected PPIs150 (15.74 %)
The number of possible different fusions37
PPI diameter4
PPI radius2
The average degree of PPI11.946
Assortativity coefficient-0.1837
The network average Clustering coefficient0.444
The number (and %) of a zero Clustering coefficients15 (10.07 %)
The number (and %) of a zero Betweenness Centrality25 (16.78 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DMD,CALR All fusions
Proteins found in more fusions APP (see 5 fusions); GRK5 (see 2 fusions); ELF3 (see 2 fusions); VCP (see 4 fusions); TKT (see 5 fusions); NR3C1 (see 8 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); APP/ALB (see 2 fusions); HUWE1 (see 4 fusions); CTNNA1 (see 4 fusions); HSP90AB1 (see 3 fusions); AHNAK (see 2 fusions); ENO1/ENO3 (see 1 fusions); MARK2 (see 2 fusions); SMARCB1 (see 12 fusions); CALR (see 8 fusions); PARK2 (see 1 fusions); UBE3A (see 1 fusions); CD40 (see 2 fusions); EWSR1 (see 1 fusions); GANAB/PRKCSH (see 1 fusions); EZR (see 2 fusions); GAN (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); HSPB1 (see 1 fusions); PCNA (see 1 fusions); MAP3K5 (see 1 fusions); B2M (see 10 fusions); MATR3 (see 4 fusions); TPD52L2 (see 2 fusions); RPA1 (see 1 fusions); NEDD4 (see 1 fusions); MSN (see 1 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DMDparental protein330.0642437.913CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
WW (PF00397, IPR001202, SM00456): WW domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DinB_2 (PF12867, IPR024775): DinB superfamily
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
2 CALRparental protein1170.09010508.439Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
3 AARSD1interactor130.51324.839tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACTA1interactor90.19470.870Actin (PF00022, IPR004000, SM00268): Actin
5 ACTR2interactor210.39580.482Actin (PF00022, IPR004000, SM00268): Actin
6 AHNAKsuppressor140.33399.621DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945)
ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain
T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein
DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993)
DUF4097 (PF13349, IPR025164): Putative adhesin
Ntox37 (PF15535, IPR029108): Bacterial toxin 37
7 ALBprotein found in more fusions50.30039.026Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
8 ANP32Boncoprotein130.47431.123FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
SDA1 (PF05285, IPR007949): SDA1
LRR_9 (PF14580): Leucine-rich repeat
9 APOBinteractor60.9000.292DUF1081 (PF06448, IPR009454): Domain of Unknown Function (DUF1081)
DUF1943 (PF09172, IPR015255, SM01169): Domain of unknown function (DUF1943)
Phage_holin_6_1 (PF09682, IPR010026): Bacteriophage holin of superfamily 6 (Holin_LLH)
Vitellogenin_N (PF01347, IPR001747, SM00638): Lipoprotein amino terminal region
DUF2807 (PF10988, IPR021255): Putative auto-transporter adhesin, head GIN domain
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
10 APPprotein found in more fusions280.131990.025APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
11 ARoncoprotein90.46412.872Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
12 ARPC1Ainteractor140.56030.441WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
13 ARPC1Binteractor130.42327.920WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
14 ARPC3interactor130.41029.087P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
15 ARPC5interactor130.42351.837P16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
16 ARRB1interactor120.242132.726Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
17 ATF2oncoprotein170.32554.672bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
18 ATP5Binteractor140.47328.369AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
19 B2Moncoprotein70.6005.333C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
20 CALUinteractor310.260382.873EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
21 CANXinteractor340.225439.350Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
22 CD1Dinteractor30.6671.000Kelch_2 (PF07646, IPR011498): Kelch motif
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
23 CD40protein found in more fusions200Glycophorin_A (PF01102, IPR001195): Glycophorin A
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
24 CDC25Aoncoprotein80.35747.313M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
25 CDK2suppressor300.264261.548Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
26 CLN5interactor50.4005.284CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
27 CNTRLoncoprotein50.4003.738APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
28 CTNNA1oncoprotein80.47624.069Vinculin (PF01044, IPR006077): Vinculin family
29 CTNNAL1interactor3021.903Vinculin (PF01044, IPR006077): Vinculin family
30 CUL7protein found in more fusions320.247284.671ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
31 DAG1interactor30.33313.964DAG1 (PF05454, IPR008465): Dystroglycan (Dystrophin-associated glycoprotein 1)
32 DISC1interactor50.10027.783HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
33 DTNAinteractor40.6675.285ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CRISPR_Cse2 (PF09485, IPR013382): CRISPR-associated protein Cse2 (CRISPR_cse2)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
34 DTNBinteractor305.414EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
SOGA (PF11365, IPR027881): Protein SOGA
35 EEF2interactor200.284217.154EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
36 EEF2Kinteractor80.39348.109Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
37 EGFRoncoprotein360.205574.256Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
38 ELAVL1oncoprotein340.218718.410RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
39 ELF3oncoprotein50.6671.333AT_hook (PF02178, IPR017956, SM00384): AT hook motif
Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
40 ENO1oncoprotein210.42958.577Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
41 ENO2interactor110.63616.350Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
42 ENO3protein found in more fusions60.6674.136Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
43 EPB41suppressor31.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
44 EWSR1oncoprotein220.44353.387RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
45 EZRprotein found in more fusions200.44456.787DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
46 F5interactor200Cu-oxidase_2 (PF07731, IPR011706): Multicopper oxidase
Cu-oxidase_3 (PF07732, IPR011707): Multicopper oxidase
LSPR (PF06049, IPR009271): Coagulation Factor V LSPD Repeat
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
DUF4672 (PF15716, IPR031445): Domain of unknown function (DUF4672)
47 F8interactor40.6671.667Cu-oxidase (PF00394, IPR001117): Multicopper oxidase
Cu-oxidase_2 (PF07731, IPR011706): Multicopper oxidase
Cu-oxidase_3 (PF07732, IPR011707): Multicopper oxidase
F5_F8_type_C (PF00754, IPR000421, SM00231): F5/8 type C domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
48 FGBinteractor100Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
49 GANprotein found in more fusions60.10040.647BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
50 GANABsuppressor220.368129.099Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
51 GRK5protein found in more fusions50.6670.487Pkinase (PF00069, IPR000719): Protein kinase domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
52 H2AFXsuppressor180.35365.480Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
53 HAUS1interactor50.50012.887THP2 (PF09432, IPR018557): Tho complex subunit THP2
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3496 (PF12001, IPR021885): Domain of unknown function (DUF3496)
54 HLA-Aoncoprotein90.41743.777DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
55 HLA-Einteractor31.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
56 HNRNPUinteractor210.271267.600CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
57 HSP90AB1oncoprotein260.340295.919HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
58 HSP90B1suppressor290.350215.280CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
59 HSPB1oncoprotein240.308217.534HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
60 HUWE1oncoprotein230.45061.691BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
61 INHAoncoprotein21.0000TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
62 ITGA3interactor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
MLANA (PF14991, IPR029242): Protein melan-A
63 KCNH2interactor40.8330.369Ion_trans (PF00520, IPR005821): Ion transport protein
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
PAS_9 (PF13426, IPR000014): PAS domain
64 KCNJ12interactor50.5006.849IRK (PF01007, IPR016449): Inward rectifier potassium channel
IRK_N (PF08466, IPR013673): Inward rectifier potassium channel N-terminal
65 KCNJ4interactor21.0000IRK (PF01007, IPR016449): Inward rectifier potassium channel
IRK_N (PF08466, IPR013673): Inward rectifier potassium channel N-terminal
66 KIF15interactor30.33317.383Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
STE (PF02200, IPR003120, SM00424): STE like transcription factor
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
FlxA (PF14282, IPR025577): FlxA-like protein
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
67 KRASoncoprotein120.273168.996Ras (PF00071, IPR001806, SM00173): Ras family
68 KRT17interactor21.0000DUF1798 (PF08807, IPR014913): Bacterial domain of unknown function (DUF1798)
Filament (PF00038, IPR001664): Intermediate filament protein
69 LGR4interactor70.4004.6767tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
70 LPAR6interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
71 LPLinteractor41.0000Lipase (PF00151, IPR013818): Lipase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
72 LPPoncoprotein100.37821.561LIM (PF00412, IPR001781, SM00132): LIM domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
73 LRIF1interactor40.6670.600LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
74 LRP1interactor70.47623.325EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
TadE (PF07811, IPR012495): TadE-like protein
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
75 MAP3K5oncoprotein60.6004.608Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
76 MAPK6oncoprotein80.33311.418Pkinase (PF00069, IPR000719): Protein kinase domain
77 MAPRE3interactor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
78 MARK2protein found in more fusions80.333143.527DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
79 MATR3protein found in more fusions170.342167.944DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
80 MBL2interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
81 MCM2oncoprotein340.333643.666AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
82 MSNoncoprotein190.47740.872DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
83 MTNR1Ainteractor30.6670.6547tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
84 NACA2interactor80.7142.800NAC (PF01849, IPR002715): NAC domain
85 NEDD4suppressor80.42941.833Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
86 NFX1interactor40.33317.912R3H (PF01424, IPR001374, SM00393): R3H domain
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
87 NKX2-1oncoprotein2023.160DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
DUF4719 (PF15843, IPR031696): Domain of unknown function (DUF4719)
88 NOS1interactor21.0000FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
NO_synthase (PF02898, IPR004030): Nitric oxide synthase, oxygenase domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
89 NR3C1protein found in more fusions80.38113.480GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
90 NSUN2interactor120.51525.075Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
91 NTMinteractor31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_3 (PF13927): Immunoglobulin domain
92 NTRK1oncoprotein490.2401004.471I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
93 NUP58interactor205.414Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
94 P4HBinteractor390.323304.355Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
95 PARK2suppressor180.360106.441IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
96 PCNAoncoprotein190.47728.448PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
97 PDIA3interactor220.255207.943Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
98 PFDN5interactor50.9000.286Prefoldin (PF02996, IPR004127): Prefoldin subunit
UPF0693 (PF16088, IPR032143): UPF0693 family
99 PLATinteractor30.3338.696EGF (PF00008, IPR000742, SM00181): EGF-like domain
fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
Kringle (PF00051, IPR000001): Kringle domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
100 PLP1interactor100Myelin_PLP (PF01275, IPR001614, SM00002): Myelin proteolipid protein (PLP or lipophilin)
101 PPME1interactor140.42319.141Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
102 PRF1oncoprotein200C2 (PF00168, IPR000008, SM00239): C2 domain
MACPF (PF01823, IPR020864, SM00457): MAC/Perforin domain
103 PRKACAinteractor120.48540.061Pkinase (PF00069, IPR000719): Protein kinase domain
104 PRKCSHprotein found in more fusions130.53825.050CDC45 (PF02724, IPR003874): CDC45-like protein
Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
EF-hand_5 (PF13202, IPR002048): EF hand
105 PSMA3interactor170.433101.759Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
106 PTGES3interactor160.38161.067CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
107 PTRFinteractor4044.064PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
108 RCN1interactor180.39250.409EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
109 RDXinteractor140.52725.614ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
110 RNF2interactor220.324100.260zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
111 RNY1interactor100NA
112 RNY3interactor100NA
113 RNY4interactor100NA
114 RPA1suppressor250.366146.378Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
115 RPA3interactor160.43849.270Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
116 SH3GL1oncoprotein150.53821.910BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
117 SH3GLB1suppressor130.57623.098BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
118 SIRT7interactor180.38668.646DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
119 SLC27A2interactor21.0000AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
120 SLC2A1interactor41.0000Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
121 SLC6A4interactor21.00005HT_transport_N (PF03491, IPR013086): Serotonin (5-HT) neurotransmitter transporter, N-terminus
SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
122 SMARCB1suppressor60.30017.549SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
123 SNTA1interactor50.5005.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
124 SNTB1interactor21.0000GATA-N (PF05349, IPR008013): GATA-type transcription activator, N-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
125 SNTB2interactor50.40080.241PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
126 SOX2oncoprotein70.4675.367HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
127 SUZ12suppressor140.55117.189DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
128 TAP1oncoprotein60.6673.667ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
129 TAPBPinteractor60.6009.994C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
130 TCTN1interactor90.6673.640DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
131 TCTN3interactor100.57811.378DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
132 TERF1interactor140.321136.836TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
133 TERF2interactor120.309119.534Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
134 TFinteractor30.6670.373Transferrin (PF00405, IPR001156, SM00094): Transferrin
135 THG1Linteractor110.57826.081Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
136 TKTprotein found in more fusions210.48958.404Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
137 TPD52L2protein found in more fusions140.44932.840TPD52 (PF04201, IPR007327): Tumour protein D52 family
138 TPT1interactor40.5001.070TCTP (PF00838, IPR018105): Translationally controlled tumour protein
139 TRAF3IP1interactor50.30013.679MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
140 TRIM21interactor50.50028.337DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
141 TSHRoncoprotein21.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
SSFA2_C (PF14723, IPR029326): Sperm-specific antigen 2 C-terminus
142 U2AF2protein found in more fusions310.372159.111RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
143 UBE3Aoncoprotein130.33350.013HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
144 UPF2interactor80.42956.985DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
145 VCPprotein found in more fusions380.245968.658AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
146 VWFinteractor30.6670.911Antistasin (PF02822, IPR004094): Antistasin family
C8 (PF08742, IPR014853, SM00832): C8 domain
Metallothio_5 (PF02067, IPR000966): Metallothionein family 5
Pacifastin_I (PF05375, IPR008037): Pacifastin inhibitor (LCMII)
TIL (PF01826, IPR002919): Trypsin Inhibitor like cysteine rich domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
VWD (PF00094, IPR001846, SM00216): von Willebrand factor type D domain
VWA_N2 (PF16164, IPR032361): VWA N-terminal
147 WDR1interactor100.7782.644eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
148 XPO1interactor300.175660.646CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
149 YWHAEoncoprotein200.347207.71514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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