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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)167
The number (and %) of the onco-proteins35 (20.96 %)
The number (and %) of the tumor suppressors10 (5.99 %)
Total number of binary PPIs (saturation %)732 (5.28 %)
The number (and %) of affected PPIs166 (22.68 %)
The number of possible different fusions15
PPI diameter4
PPI radius2
The average degree of PPI8.299
Assortativity coefficient-0.2570
The network average Clustering coefficient0.424
The number (and %) of a zero Clustering coefficients22 (13.17 %)
The number (and %) of a zero Betweenness Centrality34 (20.36 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: VAPB,MLF2 All fusions
Proteins found in more fusions VCP (see 4 fusions); HSP90AA1 (see 6 fusions); FAF1 (see 3 fusions); VHL (see 1 fusions); BAG2 (see 1 fusions); ARHGEF12 (see 2 fusions); BAG3 (see 4 fusions); INSIG1 (see 1 fusions); USP20 (see 1 fusions); VCL (see 2 fusions); HNRNPC (see 1 fusions); OXCT1 (see 1 fusions); UBC (see 7 fusions); HSP90AA1/BAG4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 VAPBparental protein1240.03315771.089ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
2 MLF2parental protein420.1362213.803Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
3 ABCD3interactor90.25096.895ABC_membrane_2 (PF06472, IPR010509): ABC transporter transmembrane region 2
ABC_tran (PF00005, IPR003439): ABC transporter
4 ABCE1interactor120.327310.521ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
5 ACBD4interactor21.0000ACBP (PF00887, IPR000582): Acyl CoA binding protein
6 ACBD5interactor60.33327.824ACBP (PF00887, IPR000582): Acyl CoA binding protein
P2 (PF07194, IPR010808): P2 response regulator binding domain
SNARE (PF05739, IPR000727, SM00397): SNARE domain
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
7 AFTPHinteractor30.6674.320Clathrin_bdg (PF15045, IPR029205): Clathrin-binding box of Aftiphilin, vesicle trafficking
DUF5102 (PF17104, IPR031355): Domain of unknown function (DUF5102)
8 AHCTF1interactor40.16712.725AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
ELYS (PF13934, IPR025151): Nuclear pore complex assembly
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin
9 AIFM1oncoprotein90.27870.041Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
10 AKAP11interactor50.70029.848E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone
RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
11 ARHGEF12suppressor41.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
Ribonuc_2-5A (PF06479, IPR010513): Ribonuclease 2-5A
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
12 ASNA1interactor90.63919.486ArsA_ATPase (PF02374, IPR025723): Anion-transporting ATPase
13 ATL3interactor30.6671.766GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
14 BAG1oncoprotein70.6677.266BAG (PF02179, IPR003103, SM00264): BAG domain
Presenilin (PF01080, IPR001108): Presenilin
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
15 BAG2protein found in more fusions150.374111.350IncA (PF04156, IPR007285): IncA protein
Mnd1 (PF03962, IPR005647): Mnd1 family
ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
16 BAG3oncoprotein140.37275.933BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
17 BAG4protein found in more fusions90.50016.620BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
18 BAG6interactor160.324214.598DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
19 BRIP1oncoprotein30.33316.739DEAD_2 (PF06733, IPR010614): DEAD_2
HBB (PF06777, IPR010643): Helical and beta-bridge domain
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
20 CAND1interactor190.235476.360Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
21 CCDC8interactor190.118395.228Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
22 CCNB2interactor30.3335.943Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
23 CEBPZinteractor40.500119.679BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain
CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
24 CIAO1interactor60.53348.442WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
25 COX4I1interactor80.6077.175COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
26 COX5Binteractor50.40014.860COX5B (PF01215, IPR002124): Cytochrome c oxidase subunit Vb
27 CTU2interactor40.500149.873CTU2 (PF10288, IPR019407): Cytoplasmic tRNA 2-thiolation protein 2
28 DDOSTinteractor120.37968.822DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
29 DNAJB1suppressor120.333110.400DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
30 DNAJB4suppressor80.46420.764DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
31 DNAJB6interactor160.250279.858DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
32 ERBB2oncoprotein70.46744.531Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
33 ESRRBsuppressor60.26766.211zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
34 FAF1protein found in more fusions130.57626.122UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
35 FAF2interactor200.175501.313DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
36 FAM118Binteractor100SIR2_2 (PF13289): SIR2-like domain
37 FAM170Ainteractor21.0000CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
zf-C2H2_4 (PF13894): C2H2-type zinc finger
38 FAM83Ginteractor3011.633DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
39 FAM96Ainteractor30.6670.952DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
40 FAM96Binteractor60.53323.152DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
41 FBXW11interactor170.192333.096WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
42 GCN1interactor80.28652.604Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
43 GET4interactor110.61853.663DUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
44 GOLT1Binteractor130.32158.772Got1 (PF04178, IPR007305): Got1/Sft2-like family
45 GPR25interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
46 GPRASP2interactor21.0000Arm_2 (PF04826, IPR006911): Armadillo-like
DUF3020 (PF11223, IPR021386): Protein of unknown function (DUF3020)
PH_4 (PF15404): Pleckstrin homology domain
47 HDAC11interactor60.33324.744Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
48 HEATR5Binteractor40.50017.646HEAT (PF02985, IPR000357): HEAT repeat
HisKA_3 (PF07730, IPR011712): Histidine kinase
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
DnaB_bind (PF10410, IPR019475): DnaB-helicase binding domain of primase
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS22L_C (PF14911, IPR029424): S-phase genomic integrity recombination mediator, C-terminal
49 HERC2interactor90.21491.847ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
50 HNRNPCprotein found in more fusions110.40076.158APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
51 HSP90AA1oncoprotein280.179502.907HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
52 HSPA6interactor80.39330.653HSP70 (PF00012, IPR013126): Hsp70 protein
53 HSPB2interactor200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
54 INPPL1oncoprotein100.40065.549Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
55 INSIG1protein found in more fusions50.8330.450INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
56 JMYinteractor100WH2 (PF02205, IPR003124, SM00246): WH2 motif
Glyco_trans_1_2 (PF13524): Glycosyl transferases group 1
JMY (PF15871, IPR031738): Junction-mediating and -regulatory protein
WHAMM-JMY_N (PF15920, IPR031808): N-terminal of Junction-mediating and WASP homolog-associated
CALM_bind (PF16025): Calcium-dependent calmodulin binding
57 KIF15interactor50.60014.788Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
STE (PF02200, IPR003120, SM00424): STE like transcription factor
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
FlxA (PF14282, IPR025577): FlxA-like protein
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
58 KRASoncoprotein90.25086.391Ras (PF00071, IPR001806, SM00173): Ras family
59 LRBAoncoprotein70.23854.128Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
DUF1088 (PF06469, IPR010508): Domain of Unknown Function (DUF1088)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
60 LSG1interactor60.40021.391cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
61 LTBRoncoprotein50.5003.501Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
62 MIGA2interactor205.548Miga (PF10265, IPR019392): Mitoguardin
63 MMS19interactor120.242188.940DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
64 MORF4L1interactor40.6671.634MRG (PF05712, IPR026541): MRG
Fmp27_WPPW (PF10359, IPR019449): RNA pol II promoter Fmp27 protein domain
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
65 MORF4L2interactor21.0000MRG (PF05712, IPR026541): MRG
66 MOV10interactor260.086557.841AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
67 MPSTinteractor40.6670.971Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
68 MT-ND5interactor100NADH5_C (PF06455, IPR010934): NADH dehydrogenase subunit 5 C-terminus
Proton_antipo_M (PF00361, IPR001750): Proton-conducting membrane transporter
Proton_antipo_N (PF00662, IPR001516): NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus
69 MTNR1Ainteractor2024.5537tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
70 NACADinteractor21.0000NAC (PF01849, IPR002715): NAC domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain
71 NANOGinteractor50.50010.492Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
72 NBR1oncoprotein40.6675.552CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
73 NDUFA7interactor50.6002.189CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
74 NDUFB8interactor70.57113.305NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
75 NDUFV3interactor50.30017.420DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NDUFV3 (PF15880, IPR026193): NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
76 NOL11interactor208.297NUC205 (PF08168, IPR012584): NUC205 domain
DUF2779 (PF11074, IPR021301): Domain of unknown function(DUF2779)
77 NTRK1oncoprotein520.1072373.419I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
78 NXF1interactor320.097783.562NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
79 OSBPinteractor70.47617.795Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
80 OSBP2interactor3011.633Flu_B_NS1 (PF02942, IPR004208): Influenza B non-structural protein (NS1)
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
81 OSBPL10interactor31.0000Flagellar_rod (PF05149, IPR007824): Paraflagellar rod protein
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH_8 (PF15409): Pleckstrin homology domain
82 OSBPL11interactor80.42977.045Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
83 OSBPL1Ainteractor100DinB (PF05163, IPR007837): DinB family
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
PH_11 (PF15413): Pleckstrin homology domain
84 OSBPL2interactor21.0000Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
85 OSBPL3oncoprotein30.3337.563Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH_8 (PF15409): Pleckstrin homology domain
86 OSBPL6interactor21.0000Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH_8 (PF15409): Pleckstrin homology domain
87 OSBPL9interactor60.53347.811Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
88 OXCT1protein found in more fusions60.5008.901CoA_trans (PF01144, IPR004165, SM00882): Coenzyme A transferase
89 PITPNM1interactor21.0000Acid_phosphat_B (PF03767, IPR005519): HAD superfamily, subfamily IIIB (Acid phosphatase)
DDHD (PF02862, IPR004177, SM01127): DDHD domain
IP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
90 PITPNM2interactor30.3335.651Acid_phosphat_B (PF03767, IPR005519): HAD superfamily, subfamily IIIB (Acid phosphatase)
DDHD (PF02862, IPR004177, SM01127): DDHD domain
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
91 PITRM1interactor100M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
92 PKN2interactor40.6675.109C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
93 PMVKinteractor30.33332.893P-mevalo_kinase (PF04275, IPR005919): Phosphomevalonate kinase
94 POP1interactor80.52424.480POP1 (PF06978, IPR009723): Ribonucleases P/MRP protein subunit POP1
POPLD (PF08170, IPR012590): POPLD (NUC188) domain
95 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
96 POU5F1oncoprotein70.40023.351Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
97 PPT1interactor21.0000Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
98 PRKAA2suppressor40.3339.335Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
99 PRKACAinteractor130.321113.303Pkinase (PF00069, IPR000719): Protein kinase domain
100 PRKACBinteractor90.52833.585Pkinase (PF00069, IPR000719): Protein kinase domain
101 PRKAR1Binteractor60.8005.155RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
102 PRKAR2Binteractor70.47667.827RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
103 RAB3GAP1interactor51.0000Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Rab3-GTPase_cat (PF13890, IPR026147): Rab3 GTPase-activating protein catalytic subunit
104 RAB3GAP2interactor51.0000RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
RAB3GAP2_C (PF14656, IPR029257): Rab3 GTPase-activating protein regulatory subunit C-terminus
105 RASSF3suppressor50.60014.963RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
106 RB1CC1suppressor70.238286.477Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
107 RFT1interactor30.6670.667Rft-1 (PF04506, IPR007594): Rft protein
108 RGS20interactor30.33312.865RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
109 RHBDD3interactor21.0000Rhomboid (PF01694, IPR022764): Rhomboid family
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
110 RMDN2interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
111 RMDN3interactor30.6671.634TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_16 (PF13432): Tetratricopeptide repeat
112 RPN2interactor110.50949.521Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
113 RPP30interactor60.5338.021RNase_P_p30 (PF01876, IPR002738): RNase P subunit p30
114 S100A16interactor80.25049.578S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
115 SCAF4interactor60.33328.457CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
116 SCDinteractor50.5002.730MerC (PF03203, IPR004891): MerC mercury resistance protein
117 SEC22Binteractor140.253115.540Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
118 SEPT9oncoprotein60.40019.606Septin (PF00735, IPR000038): Septin
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
119 SLC25A35interactor20149.597Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
120 SLC26A2interactor100Spore_YabQ (PF09578, IPR019074): Spore cortex protein YabQ (Spore_YabQ)
STAS (PF01740, IPR002645): STAS domain
Sulfate_transp (PF00916, IPR011547): Sulfate permease family
121 SLC6A15interactor21.0000SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
122 SLC7A2interactor100IncA (PF04156, IPR007285): IncA protein
AA_permease_2 (PF13520, IPR002293): Amino acid permease
AA_permease_C (PF13906, IPR029485): C-terminus of AA_permease
SIT (PF15330): SHP2-interacting transmembrane adaptor protein, SIT
123 SNX2interactor60.20072.561PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
124 SNX25interactor100Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
PX (PF00787, IPR001683, SM00312): PX domain
PXA (PF02194, IPR003114, SM00313): PXA domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
125 SNX5oncoprotein30.6671.095PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
126 SNX6interactor30.33325.998PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
127 SOX2oncoprotein170.183258.348HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
128 SRP72interactor60.53310.541BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
129 SSR4interactor90.50023.817TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
130 STARD3oncoprotein100START (PF01852, IPR002913, SM00234): START domain
MENTAL (PF10457, IPR019498): Cholesterol-capturing domain
131 STIP1interactor90.47236.243TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): WTAP/Mum2p family
132 STK4oncoprotein70.46730.086Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
133 STUB1suppressor160.400103.820U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
134 STX1Ainteractor50.6671.400Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
4HB_MCP_1 (PF12729, IPR024478): Four helix bundle sensory module for signal transduction
135 STX1Binteractor30.6670.400Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
136 STX2interactor40.16718.568Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
137 STX4oncoprotein70.26731.935Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
138 STX5interactor80.35714.576Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
139 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
140 SYNRGinteractor204.320EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
141 TACC1oncoprotein50.40022.452TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
DUF4613 (PF15390, IPR028041): Domain of unknown function (DUF4613)
142 TCTN2interactor100.31133.015DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
143 TJP1interactor60.46730.211DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
RPOL_N (PF14700, IPR029262): DNA-directed RNA polymerase N-terminal
144 TMEM216interactor120.288122.460Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
145 TTC1interactor70.333140.861TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
146 TTC39Boncoprotein100DUF3808 (PF10300, IPR019412): Protein of unknown function (DUF3808)
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
147 UBCprotein found in more fusions290.225919.092ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
148 UBE4Ainteractor21.0000Ufd2P_core (PF10408, IPR019474): Ubiquitin elongating factor core
U-box (PF04564, IPR003613, SM00504): U-box domain
149 UBL4Ainteractor180.281205.742ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
150 UQCRC2oncoprotein130.37290.866Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
151 UQCRFS1interactor100.26764.009Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
152 USP19interactor80.46424.959CS (PF04969, IPR007052): CS domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP19_linker (PF16602): Linker region of USP19 deubiquitinase
153 USP20protein found in more fusions70.40042.763UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
154 USP33suppressor40.8331.293UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
155 VAMP1interactor50.4005.606Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
156 VAMP2interactor130.25653.549Synaptobrevin (PF00957, IPR001388): Synaptobrevin
PRIMA1 (PF16101): Proline-rich membrane anchor 1
157 VAPAinteractor510.0871528.849DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
158 VCLoncoprotein60.50012.843Vinculin (PF01044, IPR006077): Vinculin family
159 VCPprotein found in more fusions260.220597.589AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
160 VDAC3interactor100.44433.821Porin_3 (PF01459, IPR027246): Eukaryotic porin
161 VHLsuppressor90.39353.764Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): VHL beta domain
VHL_C (PF17211): VHL box domain
162 VKORC1interactor41.0000VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
163 VPS13Ainteractor21.0000ATG_C (PF09333, IPR015412): Autophagy-related protein C terminal domain
SHR-BD (PF06650, IPR009543): SHR-binding domain of vacuolar-sorting associated protein 13
DUF1493 (PF07377, IPR010862): Protein of unknown function (DUF1493)
Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
VPS13_C (PF16909, IPR031645): Vacuolar-sorting-associated 13 protein C-terminal
VPS13_mid_rpt (PF16910, IPR031642): Repeating coiled region of VPS13
164 WDR44interactor31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pap_E4 (PF02711, IPR003861): E4 protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
165 XPO1interactor290.118736.389CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
166 YBX1oncoprotein90.333149.820CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
167 ZDBF2interactor2027.097ZapB (PF06005, IPR009252): Cell division protein ZapB
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Pap_E4 (PF02711, IPR003861): E4 protein
zf-DBF (PF07535, IPR006572, SM00586): DBF zinc finger
DUF3905 (PF13045, IPR024999): Protein of unknown function (DUF3905)
YhfH (PF14149, IPR025432): YhfH-like protein
Uds1 (PF15456, IPR029191): Up-regulated During Septation

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