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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)62
The number (and %) of the onco-proteins16 (25.81 %)
The number (and %) of the tumor suppressors2 (3.23 %)
Total number of binary PPIs (saturation %)175 (9.25 %)
The number (and %) of affected PPIs61 (34.86 %)
The number of possible different fusions10
PPI diameter5
PPI radius3
The average degree of PPI4.968
Assortativity coefficient-0.2137
The network average Clustering coefficient0.410
The number (and %) of a zero Clustering coefficients19 (30.65 %)
The number (and %) of a zero Betweenness Centrality20 (32.26 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SRP9,TNKS2 All fusions
Proteins found in more fusions AP2M1 (see 4 fusions); HSF1 (see 3 fusions); DCTN1 (see 2 fusions); S100A10 (see 1 fusions); SF1 (see 1 fusions); AURKA (see 1 fusions); DHPS (see 2 fusions); MAPK1 (see 2 fusions); MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SRP9parental protein450.0832308.369SRP9-21 (PF05486): Signal recognition particle 9 kDa protein (SRP9)
2 TNKS2parental protein160.010992.689Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
3 AAMPinteractor50.7006.000PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 AARSinteractor80.35728.015DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
5 ABCE1interactor70.33385.973ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
6 ACTR2interactor60.3338.500Actin (PF00022, IPR004000, SM00268): Actin
7 AP2M1protein found in more fusions3095.051Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
8 AURKAoncoprotein40.333106.574Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
9 BABAM1interactor2066.074VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
10 BMI1oncoprotein80.524124.580zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
11 CC2D2Ainteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
ZnuA (PF01297, IPR006127): Zinc-uptake complex component A periplasmic
DUF4240 (PF14024, IPR025334): Protein of unknown function (DUF4240)
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
CC2D2AN-C2 (PF15625, IPR028928): CC2D2A N-terminal C2 domain
12 CEP152interactor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
FAD-SLDH (PF12318, IPR024651): Membrane bound FAD containing D-sorbitol dehydrogenase
YtxH (PF12732, IPR024623): YtxH-like protein
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13 CEP19interactor100CEP19 (PF14933, IPR029412): CEP19-like protein
14 CNTRLoncoprotein21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
15 CUL5suppressor20100.863Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16 DCTN1protein found in more fusions30105.241Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
17 DDX20interactor90.6439.844DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18 DHPSprotein found in more fusions70.5338.214DS (PF01916, IPR002773): Deoxyhypusine synthase
19 DPP8interactor50.5003.500DPPIV_N (PF00930, IPR002469): Dipeptidyl peptidase IV (DPP IV) N-terminal region
Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family)
Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
20 EEF2Kinteractor40.5002.167Alpha_kinase (PF02816, IPR004166, SM00811): Alpha-kinase family
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
21 EPN3interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
22 EXOSC1interactor100EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
23 FTCDinteractor21.0000FTCD (PF02971, IPR013802): Formiminotransferase domain
FTCD_C (PF04961, IPR007044): Formiminotransferase-cyclodeaminase
FTCD_N (PF07837, IPR012886): Formiminotransferase domain, N-terminal subdomain
24 GEMIN2interactor70.9051.206SIP1 (PF04938): Survival motor neuron (SMN) interacting protein 1 (SIP1)
Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
25 GEMIN4interactor90.7506.661NA
26 GEMIN5interactor90.556168.085WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
27 GRB14interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
28 HSF1protein found in more fusions100.361155.080DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
29 IL7Rinteractor30.6671.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
30 IPO11interactor40.8330.667DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
31 ITGA4interactor70.400158.070FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
32 LARSinteractor40.6672.500Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
33 LNPEPoncoprotein100Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
Dynactin (PF12455, IPR022157): Dynein associated protein
34 MAPK1oncoprotein60369.408Pkinase (PF00069, IPR000719): Protein kinase domain
35 METTL18interactor31.0000Methyltransf_23 (PF13489): Methyltransferase domain
36 MGMTinteractor100DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain
Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
37 MYConcoprotein80.286103.684HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
38 OTUB1interactor40.33342.104Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
39 P3H1interactor70.42914.339TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
YfiO (PF13525): Outer membrane lipoprotein
2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
MCM_N (PF14551, IPR027925): MCM N-terminal domain
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
40 PAXIP1interactor40.333124.908BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
41 PLIN3interactor90.42913.405Perilipin (PF03036, IPR004279): Perilipin family
42 POU5F1oncoprotein80.33318.289Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
43 PTENsuppressor30154.743DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
44 PTGES3interactor40.6670.500CS (PF04969, IPR007052): CS domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
45 RNF166interactor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
46 RPRD1Ainteractor50.5005.460CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain.
GlutR_N (PF05201, IPR015895): Glutamyl-tRNAGlu reductase, N-terminal domain
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour
47 S100A10oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
48 SCLT1oncoprotein21.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
49 SF1protein found in more fusions50.5007.885UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
50 SH3BP2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
51 SLC35A5interactor100Nuc_sug_transp (PF04142, IPR007271): Nucleotide-sugar transporter
52 SMN1interactor90.7508.106SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
53 SRP14interactor130.21869.378SRP14 (PF02290, IPR003210): Signal recognition particle 14kD protein
54 SRP54interactor90.6798.3675_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
SRP54 (PF00448, IPR000897, SM00962): SRP54-type protein, GTPase domain
SRP54_N (PF02881, IPR013822, SM00963): SRP54-type protein, helical bundle domain
SRP_SPB (PF02978, IPR004125): Signal peptide binding domain
YlbD_coat (PF14071, IPR025953): Putative coat protein
55 SRP68interactor50.7002.167RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
SRP68 (PF16969, IPR026258): RNA-binding signal recognition particle 68
56 SZRD1interactor31.0000SUZ (PF12752, IPR024771): SUZ domain
SUZ-C (PF12901, IPR024642): SUZ-C motif
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
57 TERF1interactor200TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
58 TMEM237interactor100TMEM237 (PF15383, IPR029409): Transmembrane protein 237
59 TNKS1BP1interactor2047.741Tankyrase_bdg_C (PF15327, IPR032764): Tankyrase binding protein C terminal domain
60 TOMM40interactor21.0000Porin_3 (PF01459, IPR027246): Eukaryotic porin
61 TXNoncoprotein60.26780.285Thioredoxin (PF00085, IPR013766): Thioredoxin
62 ZNF512Binteractor2048.308YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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