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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TNKS2, ZCCHC11 (from a repository: Sat Aug 17 10:29:27 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins8 (28.57 %)
The number (and %) of the tumor suppressors5 (17.86 %)
Total number of binary PPIs (saturation %)69 (18.25 %)
The number (and %) of affected PPIs28 (40.58 %)
The number of possible different fusions6
PPI diameter4
PPI radius2
The average degree of PPI4.214
Assortativity coefficient-0.6346
The network average Clustering coefficient0.366
The number (and %) of a zero Clustering coefficients14 (50.00 %)
The number (and %) of a zero Betweenness Centrality15 (53.57 %)


List of the fusions

PPI for parental proteins: TUT4,TNKS2 All fusions
Proteins found in more fusions AP2M1 (see 4 fusions); COPS5 (see 1 fusions); MAPK1 (see 2 fusions); CUL1 (see 3 fusions); MYC (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ZCCHC11parental protein120.424126.841NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
PAP_assoc (PF03828, IPR002058): Cid1 family poly A polymerase
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCHC_2 (PF13696, IPR025829): Zinc knuckle
zf-CCHC_5 (PF14787): GAG-polyprotein viral zinc-finger
2 TNKS2parental protein160.010494.444Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
3 AP2M1protein found in more fusions200Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
4 BABAM1interactor100VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
5 CAND1interactor90.8931.175Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6 COPS5protein found in more fusions90.8931.175JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 CUL1suppressor80.7623.175Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
8 CUL2suppressor70.9520.508Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
9 CUL4Boncoprotein70.9520.508Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
10 CUL5suppressor90.694252.730Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
11 DCUN1D1interactor80.67914.333Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
12 ELAVL1oncoprotein110.48952.222RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 EPN3interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
14 FTCDinteractor21.0000FTCD (PF02971, IPR013802): Formiminotransferase domain
FTCD_C (PF04961, IPR007044): Formiminotransferase-cyclodeaminase
FTCD_N (PF07837, IPR012886): Formiminotransferase domain, N-terminal subdomain
15 GRB14interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
16 LNPEPoncoprotein100Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
Dynactin (PF12455, IPR022157): Dynein associated protein
17 MAPK1oncoprotein4039.889Pkinase (PF00069, IPR000719): Protein kinase domain
18 MIR363interactor100NA
19 MIRLET7A1suppressor100NA
20 MYConcoprotein50.5007.333HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
21 PTENsuppressor2021.667DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
22 RNF166interactor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
23 SH3BP2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
24 SLC35A5interactor100Nuc_sug_transp (PF04142, IPR007271): Nucleotide-sugar transporter
25 TERF1interactor200TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
26 TIFAinteractor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
27 TNKS1BP1interactor100Tankyrase_bdg_C (PF15327, IPR032764): Tankyrase binding protein C terminal domain
28 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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