Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TNKS2, UPP2 (from a repository: Sat Aug 3 04:35:41 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins4 (21.05 %)
The number (and %) of the tumor suppressors4 (21.05 %)
Total number of binary PPIs (saturation %)26 (15.20 %)
The number (and %) of affected PPIs19 (73.08 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.000
Assortativity coefficient-0.4824
The network average Clustering coefficient0.106
The number (and %) of a zero Clustering coefficients16 (84.21 %)
The number (and %) of a zero Betweenness Centrality15 (78.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: UPP2,TNKS2 All fusions
Proteins found in more fusions VIM (see 1 fusions); MAPK1 (see 2 fusions); AP2M1 (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 UPP2parental protein3034.000PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
2 TNKS2parental protein160.010292.000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
3 AP2M1protein found in more fusions200Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
4 BABAM1interactor100VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
5 CUL5suppressor100Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
6 EPN3interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
7 FTCDinteractor21.0000FTCD (PF02971, IPR013802): Formiminotransferase domain
FTCD_C (PF04961, IPR007044): Formiminotransferase-cyclodeaminase
FTCD_N (PF07837, IPR012886): Formiminotransferase domain, N-terminal subdomain
8 GRB14interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
9 LNPEPoncoprotein100Peptidase_M1 (PF01433, IPR014782): Peptidase family M1
ERAP1_C (PF11838, IPR024571): ERAP1-like C-terminal domain
Dynactin (PF12455, IPR022157): Dynein associated protein
10 MAPK1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
11 PTENsuppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
12 RNF166interactor100zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zinc-ribbons_6 (PF07191, IPR010807): zinc-ribbons
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
13 SH3BP2oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
14 SIAH1suppressor3064.000Sina (PF03145, IPR018121): Seven in absentia protein family
15 SLC35A5interactor100Nuc_sug_transp (PF04142, IPR007271): Nucleotide-sugar transporter
16 TERF1interactor200TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
17 TNKS1BP1interactor100Tankyrase_bdg_C (PF15327, IPR032764): Tankyrase binding protein C terminal domain
18 VIMsuppressor200Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
19 ZNF512Binteractor2090.000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

B a c k    t o    T o p ⇑