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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins SIKE1 (from a repository: Wed May 17 13:36:22 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins4 (14.29 %)
The number (and %) of the tumor suppressors4 (14.29 %)
Total number of binary PPIs (saturation %)169 (44.71 %)
The number (and %) of affected PPIs27 (15.98 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI11.714
Assortativity coefficient-0.3544
The network average Clustering coefficient0.767
The number (and %) of a zero Clustering coefficients4 (14.29 %)
The number (and %) of a zero Betweenness Centrality11 (39.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: SIKE1 All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SIKE1parental protein270.390309.705DUF837 (PF05769, IPR008555): Protein of unknown function (DUF837)
Rho_Binding (PF08912, IPR015008): Rho Binding
2 AGGF1interactor200DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
FHA (PF00498, IPR000253, SM00240): FHA domain
G-patch (PF01585, IPR000467, SM00443): G-patch domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
WW (PF00397, IPR001202, SM00456): WW domain
YL1_C (PF08265, IPR013272, SM00993): YL1 nuclear protein C-terminal domain
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
3 ASH1Linteractor100AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BAH (PF01426, IPR001025, SM00439): BAH domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SET (PF00856, IPR001214, SM00317): SET domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
4 BTDinteractor100CN_hydrolase (PF00795, IPR003010): Carbon-nitrogen hydrolase
5 ELLoncoprotein31.0000Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
6 EMDinteractor31.0000LEM (PF03020, IPR003887, SM00540): LEM domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
7 FGFR1OP2oncoprotein210.64357.705Cauli_AT (PF03233, IPR004917): Aphid transmission protein
DUF837 (PF05769, IPR008555): Protein of unknown function (DUF837)
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
8 ICE2interactor31.0000NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
9 MOB4interactor180.8564.705Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
10 MRPL58interactor100RF-1 (PF00472, IPR000352): RF-1 domain
11 PDCD10interactor160.9331.389DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1
12 PPP2CAsuppressor170.9122.050Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
13 PPP2CBsuppressor170.83816.162Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
14 PPP2R1Aoncoprotein160.9331.389TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
15 PPP2R1Bsuppressor131.0000HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
16 RASIP1interactor21.0000DIL (PF01843, IPR018444, SM01132): DIL domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
17 RASSF3suppressor81.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
18 SLMAPinteractor170.8823.531Fez1 (PF06818): Fez1
FHA (PF00498, IPR000253, SM00240): FHA domain
Spectrin (PF00435, IPR002017): Spectrin repeat
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
19 STK24interactor180.9122.050DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
20 STK25interactor160.9421.162DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
21 STK26interactor160.9710.462DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
22 STRIP1interactor170.8823.450ELM2 (PF01448, IPR000949): ELM2 domain
N1221 (PF07923, IPR012486): N1221-like protein
DUF3402 (PF11882, IPR021819): Domain of unknown function (DUF3402)
23 STRIP2interactor130.9490.667N1221 (PF07923, IPR012486): N1221-like protein
DUF3402 (PF11882, IPR021819): Domain of unknown function (DUF3402)
24 STRNoncoprotein180.8564.705CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Nucleoporin_N (PF08801, IPR014908): Nup133 N terminal like
Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
25 STRN3interactor180.8564.705Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
26 STRN4interactor160.9002.702CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
27 TRAF3IP3interactor130.82111.462ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
28 TTC1interactor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat

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