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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PTGES2, MTATP6P1 (from a repository: Mon Aug 12 16:22:05 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins2 (14.29 %)
The number (and %) of the tumor suppressors2 (14.29 %)
Total number of binary PPIs (saturation %)19 (20.88 %)
The number (and %) of affected PPIs13 (68.42 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI1.857
Assortativity coefficient-0.5270
The network average Clustering coefficient0.144
The number (and %) of a zero Clustering coefficients11 (78.57 %)
The number (and %) of a zero Betweenness Centrality13 (92.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MTATP6P1,PTGES2 All fusions
Proteins found in more fusions MYC (see 2 fusions); PTGES2 (see 1 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MTATP6P1interactor000NA
2 PTGES2parental protein130.015130.000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
3 C15orf48interactor21.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
4 C1orf189interactor100DUF4558 (PF15104, IPR029375): Domain of unknown function (DUF4558)
5 COQ9interactor31.0000COQ9 (PF08511, IPR013718): COQ9
6 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
7 EID3interactor200Nse4_C (PF08743, IPR014854): Nse4 C-terminal
Nse4-Nse3_bdg (PF15412, IPR029225): Binding domain of Nse4/EID3 to Nse3-MAGE
8 EXOSC10interactor100DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
9 H2AFXsuppressor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
10 HTTprotein found in more fusions200HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
11 MYConcoprotein200HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
12 NDUFA4interactor200B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
13 SHISA2interactor100Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
14 UQCR11interactor100UCR_6-4kD (PF08997, IPR015089): Ubiquinol-cytochrome C reductase complex, 6.4kD protein

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