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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins LRRTM4, PELI1 (from a repository: Sun Aug 25 14:12:59 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins11 (40.74 %)
The number (and %) of the tumor suppressors1 (3.70 %)
Total number of binary PPIs (saturation %)82 (23.36 %)
The number (and %) of affected PPIs25 (30.49 %)
The number of possible different fusions10
PPI diameter2
PPI radiusinf
The average degree of PPI4.889
Assortativity coefficient-0.2094
The network average Clustering coefficient0.637
The number (and %) of a zero Clustering coefficients5 (18.52 %)
The number (and %) of a zero Betweenness Centrality14 (51.85 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions RIPK1 (see 1 fusions); UBE2D2 (see 2 fusions); TRAF6 (see 1 fusions); UBE2N (see 1 fusions); IKBKB (see 2 fusions); BCL6 (see 2 fusions); SRPK2 (see 1 fusions); UBC (see 1 fusions); VAC14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LRRTM4parental protein100LSR (PF05624, IPR008664): Lipolysis stimulated receptor (LSR)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
2 PELI1parental protein240.149385.000Pellino (PF04710, IPR006800): Pellino
3 BCL6oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4 DEAF1interactor100Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAND (PF01342, IPR000770, SM00258): SAND domain
zf-MYND (PF01753, IPR002893): MYND finger
5 IKBKBprotein found in more fusions60.5003.833FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
6 IL1R1interactor61.0000TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
7 IRAK1interactor80.8102.667Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
8 IRAK2oncoprotein61.0000Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
9 IRAK4interactor61.0000Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
10 IRS1interactor30.6670.500CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
11 MYD88oncoprotein80.7625.000Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
12 NR2C2suppressor31.0000Flagellin_N (PF00669, IPR001029): Bacterial flagellin N-terminal helical region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
13 PILRAinteractor100SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
G6B (PF15096, IPR028070): G6B family
14 RIPK1protein found in more fusions50.6671.167Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
15 SMAD6interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
16 SRPK1interactor21.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
17 SRPK2oncoprotein40.6671.000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
18 TBK1interactor200DUF713 (PF05218, IPR007883): Protein of unknown function (DUF713)
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Pkinase (PF00069, IPR000719): Protein kinase domain
19 TRAF6protein found in more fusions150.35254.500SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
20 TRIP13interactor31.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
21 UBCprotein found in more fusions90.53610.167ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
22 UBE2D1interactor51.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
23 UBE2D2oncoprotein70.7332.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
24 UBE2Iinteractor50.6672.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
25 UBE2Nprotein found in more fusions60.8001.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
26 UBE2V1interactor50.9000.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
27 VAC14oncoprotein31.0000TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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