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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins WWC2, BEX1 (from a repository: Mon Aug 19 02:38:29 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins6 (21.43 %)
The number (and %) of the tumor suppressors10 (35.71 %)
Total number of binary PPIs (saturation %)64 (16.93 %)
The number (and %) of affected PPIs27 (42.19 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.714
Assortativity coefficient-0.6085
The network average Clustering coefficient0.296
The number (and %) of a zero Clustering coefficients12 (42.86 %)
The number (and %) of a zero Betweenness Centrality13 (46.43 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: BEX1,WWC2 All fusions
Proteins found in more fusions FGFR2 (see 3 fusions); REPS1 (see 1 fusions); SMAD4 (see 3 fusions); WWC2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BEX1parental protein150.038407.643BEX (PF04538, IPR021156): Brain expressed X-linked like family
2 WWC2parental protein120.273145.548DASH_Dad2 (PF08654, IPR013963): DASH complex subunit Dad2
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Phage_Nu1 (PF07471, IPR010906): Phage DNA packaging protein Nu1
WW (PF00397, IPR001202, SM00456): WW domain
3 BAG4interactor100BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
4 BCAR3oncoprotein100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
5 CASP8suppressor31.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
6 CHEK2suppressor3038.024FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
7 DLC1suppressor40.50030.357RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
START (PF01852, IPR002913, SM00234): START domain
DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
8 FBXW7suppressor50.33346.714Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
9 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
10 FZR1suppressor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 GSK3Bsuppressor50.16771.024Pkinase (PF00069, IPR000719): Protein kinase domain
12 LATS1suppressor60.66742.952Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
13 LATS2suppressor70.60037.857Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
14 LDLRAD4interactor100Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
15 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
16 OMPinteractor100Olfactory_mark (PF06554, IPR009103): Olfactory marker protein
17 PAX2oncoprotein100PAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
18 PIK3CAoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
19 PRKCAinteractor50.50026.881C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
20 PTENsuppressor60.267113.119DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
21 PTPN14oncoprotein50.70031.667FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
22 REPS1protein found in more fusions200Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC)
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
23 SMAD4suppressor3024.643MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
24 TEX11interactor100SPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat
25 WWC1interactor90.41743.548APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
26 WWC3interactor70.6675.571APG6 (PF04111, IPR007243): Autophagy protein Apg6
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
IncA (PF04156, IPR007285): IncA protein
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain
DUF4452 (PF14618, IPR027915): Domain of unknown function (DUF4452)
LURAP (PF14854): Leucine rich adaptor protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
27 XPO1interactor40.16752.452CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
28 YWHAQinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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