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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)163
The number (and %) of the onco-proteins28 (17.18 %)
The number (and %) of the tumor suppressors9 (5.52 %)
Total number of binary PPIs (saturation %)630 (4.77 %)
The number (and %) of affected PPIs161 (25.56 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI7.411
Assortativity coefficient-0.4077
The network average Clustering coefficient0.485
The number (and %) of a zero Clustering coefficients58 (35.58 %)
The number (and %) of a zero Betweenness Centrality88 (53.99 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EXTL3,CEP76 All fusions
Proteins found in more fusions HSP90AA1 (see 6 fusions); PRPF19 (see 2 fusions); GFAP (see 3 fusions); PLEKHA5 (see 2 fusions); DCTD (see 1 fusions); HSP90AB1 (see 3 fusions); CAMK2D (see 1 fusions); CSNK2A1 (see 2 fusions); PLCB1 (see 1 fusions); HSP90AA1/TUBB (see 1 fusions); HNRNPU/RPL24 (see 1 fusions); THRA (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EXTL3parental protein100.0222224.300Exostosin (PF03016, IPR004263): Exostosin family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Glyco_transf_64 (PF09258, IPR015338): Glycosyl transferase family 64 domain
2 CEP76parental protein1510.03923418.683Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
3 ABRoncoprotein100C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PH_10 (PF15411): Pleckstrin homology domain
Tox-PL-2 (PF15643, IPR028910): Papain fold toxin 2
4 AKAP7interactor100AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain
5 AMOToncoprotein40.6675.533FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
6 BANPsuppressor50.5003.000DUF1845 (PF08900, IPR014996): Domain of unknown function (DUF1845)
BEN (PF10523, IPR018379, SM01025): BEN domain
7 C22orf39interactor21.0000DUF3128 (PF11326, IPR021475): Protein of unknown function (DUF3128)
8 CABP5interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CALUinteractor60.3337.900EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
10 CAMK2Doncoprotein50.6672.000CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CCDC92interactor20640.168Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
CCDC92 (PF14916): Coiled-coil domain of unknown function
12 CCNKinteractor30.6671.000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
13 CCP110interactor70.57129.633DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
CALM_bind (PF16025): Calcium-dependent calmodulin binding
14 CENPJinteractor40.6672.000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1795 (PF08786, IPR014894): Domain of unknown function (DUF1795)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Rota_VP2 (PF05087, IPR007779): Rotavirus VP2 protein
Tcp10_C (PF07202, IPR009852): T-complex protein 10 C-terminus
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
AAA_23 (PF13476): AAA domain
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
15 CEP104interactor41.0000ATP-synt_E_2 (PF08112, IPR012508): ATP synthase epsilon subunit
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
HEAT (PF02985, IPR000357): HEAT repeat
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
UVR (PF02151, IPR001943): UvrB/uvrC motif
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
CLASP_N (PF12348, IPR024395): CLASP N terminal
DZR (PF12773, IPR025874): Double zinc ribbon
zf-C2H2_4 (PF13894): C2H2-type zinc finger
16 CEP290interactor50.9000.500ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fez1 (PF06818): Fez1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HemY_N (PF07219, IPR010817): HemY protein N-terminus
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mnd1 (PF03962, IPR005647): Mnd1 family
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Rho_Binding (PF08912, IPR015008): Rho Binding
Sec20 (PF03908, IPR005606): Sec20
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Swi5 (PF07061, IPR010760): Swi5
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
LIDHydrolase (PF10230, IPR019363): Lipid-droplet associated hydrolase
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
CEP209_CC5 (PF16574, IPR032321): Coiled-coil region of centrosome protein CE290
17 CEP55interactor60.4006.000DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
zf-C2H2_3 (PF13878, IPR028005): zinc-finger of acetyl-transferase ESCO
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
18 CEP97interactor70.5717.500IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
19 CIR1interactor100DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
IncA (PF04156, IPR007285): IncA protein
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
YebO (PF13974, IPR025594): YebO-like protein
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
20 COILinteractor31.0000CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
21 CRYBA4interactor100Crystall (PF00030, IPR001064, SM00247): Beta/Gamma crystallin
22 CSNK1G1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
CK1gamma_C (PF12605, IPR022247): Casein kinase 1 gamma C terminal
23 CSNK2A1oncoprotein100.25026.167Pkinase (PF00069, IPR000719): Protein kinase domain
24 CUTCinteractor200CutC (PF03932, IPR005627): CutC family
25 DCAF7interactor30.6671.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
26 DCTDprotein found in more fusions200dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
27 DCUN1D1interactor190.287153.549Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
28 DSC1interactor21.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
29 DSG1interactor30.6671.000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
30 DZIP1Linteractor100Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1
Phlebovirus_NSM (PF07246, IPR009879): Phlebovirus nonstructural protein NS-M
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Dzip-like_N (PF13815, IPR032714): Iguana/Dzip1-like DAZ-interacting protein N-terminal
31 EAF1suppressor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
32 EEF1A2oncoprotein30.6670.333GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
33 EP400NLinteractor100EP400_N (PF15790, IPR031575): E1A-binding protein p400, N-terminal
34 F7interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
35 FAM60Ainteractor100FAM60A (PF15396, IPR026065): Protein Family FAM60A
36 FAM90A1interactor30.6671.000zf-CCHC_6 (PF15288): Zinc knuckle
37 FAM96Binteractor21.0000DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
38 FHL5interactor31.0000LIM (PF00412, IPR001781, SM00132): LIM domain
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
39 GDAP2interactor100Macro (PF01661, IPR002589, SM00506): Macro domain
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
40 GFAPprotein found in more fusions40.6671.000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
41 GIGYF2interactor21.0000DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GYF (PF02213, IPR003169, SM00444): GYF domain
Macoilin (PF09726, IPR019130): Transmembrane protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
AAA_23 (PF13476): AAA domain
ARGLU (PF15346): Arginine and glutamate-rich 1
PRTase_3 (PF15610, IPR028944): PRTase ComF-like
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
42 GLRA2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
43 GRWD1interactor100Voldacs (PF03517): Regulator of volume decrease after cellular swelling
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
44 HNRNPH1oncoprotein70.5717.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
45 HNRNPUprotein found in more fusions330.473237.222CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
46 HPCAL1interactor100DUF2554 (PF10829, IPR020117): Protein of unknown function (DUF2554)
47 HRNRinteractor100DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
48 HSP90AA1oncoprotein230.273190.913HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
49 HSP90AB1oncoprotein160.42992.229HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
50 HSPA1Ainteractor80.7144.567HSP70 (PF00012, IPR013126): Hsp70 protein
51 HSPA2interactor40.8330.500HSP70 (PF00012, IPR013126): Hsp70 protein
52 HSPA5oncoprotein190.275133.383HSP70 (PF00012, IPR013126): Hsp70 protein
53 HSPA9oncoprotein60.5335.700HSP70 (PF00012, IPR013126): Hsp70 protein
54 HSPB7suppressor100HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
55 IGHV3-48interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
56 ILVBLinteractor100TPP_enzyme_C (PF02775, IPR011766): Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
TPP_enzyme_N (PF02776, IPR012001): Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
57 IQGAP1interactor60.53314.733CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
58 IRS4interactor50.4003.833CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
59 KIAA1143interactor100DUF4604 (PF15377, IPR027911): Domain of unknown function (DUF4604)
60 KIF1BPinteractor21.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
KBP_C (PF12309, IPR022083): KIF-1 binding protein C terminal
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
61 KLHDC4interactor100Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
YqzE (PF14038, IPR025622): YqzE-like protein
62 LATS1suppressor60.333963.448Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
63 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
64 LRPPRCinteractor100DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
65 MAGEA11interactor50.5003.000MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
66 MBD3interactor31.0000DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
67 MED23interactor21.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
68 MOGSinteractor21.0000Glyco_hydro_63 (PF03200, IPR004888): Glycosyl hydrolase family 63 C-terminal domain
Glyco_hydro_63N (PF16923, IPR031631): Glycosyl hydrolase family 63 N-terminal domain
69 MRPS11interactor41.0000Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
70 MRPS16interactor40.6672.000Ribosomal_S16 (PF00886, IPR000307): Ribosomal protein S16
FtsK_4TM (PF13491, IPR025199): 4TM region of DNA translocase FtsK/SpoIIIE
71 MRPS23interactor30.6670.667MRP-S23 (PF10484, IPR023611): Mitochondrial ribosomal protein S23
72 MRPS25interactor40.6671.400L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
73 MRPS26interactor21.0000MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
74 MRPS27interactor30.6670.667MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
75 MRPS7interactor50.7002.000DUF454 (PF04304, IPR007401): Protein of unknown function (DUF454)
Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
76 MYL6Binteractor21.0000SapB_1 (PF05184, IPR007856): Saposin-like type B, region 1
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
77 NDUFAF3interactor100DUF498 (PF04430, IPR007523): Protein of unknown function (DUF498/DUF598)
78 NEURL4interactor41.0000Neuralized (PF07177, IPR006573, SM00588): Neuralized
79 NHLRC2interactor100NHL (PF01436, IPR001258): NHL repeat
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Thioredoxin_8 (PF13905, IPR012336): Thioredoxin-like
80 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
81 PAICSinteractor200AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
82 PARD6Binteractor21.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
83 PIN1suppressor70.33314.000Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
84 PLCB1oncoprotein200DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
85 PLEKHA5protein found in more fusions401230.451PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
86 POM121interactor30.6671.000Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
87 PPFIBP1oncoprotein31.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
XkdW (PF09636, IPR019094): XkdW protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
88 PPP3CAinteractor21.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
89 PPP3CBinteractor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
PRIMA1 (PF16101): Proline-rich membrane anchor 1
90 PRPF19protein found in more fusions31.0000Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
91 PRRC2Cinteractor100BAT2_N (PF07001, IPR009738): BAT2 N-terminus
Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
GRP (PF07172, IPR010800): Glycine rich protein family
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
DUF4661 (PF15576, IPR029073): Domain of unknown function (DUF4661)
PET117 (PF15786, IPR031568): PET assembly of cytochrome c oxidase, mitochondrial
92 RAD23Aoncoprotein200UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
93 RADILinteractor21.0000DIL (PF01843, IPR018444, SM01132): DIL domain
FHA (PF00498, IPR000253, SM00240): FHA domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
94 RAVER1interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
95 RBBP4oncoprotein30.6671.000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
96 RCN1interactor40.5002.400EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
97 RCN2interactor30.6670.400EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
98 RFC2interactor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_16 (PF13191): AAA ATPase domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
99 RNF128interactor200CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
100 RPL10Linteractor220.9780.468Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
Cytochrome_P460 (PF16694, IPR032033): Cytochrome P460
101 RPL17interactor250.78322.462Ribosomal_L22 (PF00237, IPR001063): Ribosomal protein L22p/L17e
102 RPL21interactor260.86524.968Ribosomal_L21e (PF01157, IPR001147): Ribosomal protein L21e
103 RPL22oncoprotein250.9332.301Ribosomal_L22e (PF01776, IPR002671): Ribosomal L22e protein family
104 RPL23interactor280.76735.241Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
105 RPL23Ainteractor270.79525.971Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
106 RPL24protein found in more fusions250.9332.301MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Ribosomal_L24e (PF01246, IPR000988): Ribosomal protein L24e
107 RPL26oncoprotein160.9830.182TP2 (PF01254, IPR000678): Nuclear transition protein 2
Ribosomal_L26 (PF16906, IPR005756): Ribosomal proteins L26 eukaryotic, L24P archaeal
108 RPL30interactor240.87722.064NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
109 RPL31interactor240.88822.918Ribosomal_L31e (PF01198, IPR000054): Ribosomal protein L31e
110 RPL38interactor220.9571.169Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
111 RPL9interactor270.78332.181Ribosomal_L6 (PF00347, IPR020040): Ribosomal protein L6
112 RPS11interactor250.9332.301Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
Ribosomal_S17_N (PF16205, IPR032440): Ribosomal_S17 N-terminal
113 RPS14interactor240.9491.584Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
114 RPS15interactor240.9381.992Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
115 RPS15Ainteractor280.73859.300Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
116 RPS16interactor290.74136.072Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
117 RPS17interactor190.9940.091Ribosomal_S17e (PF00833, IPR001210): Ribosomal S17
118 RPS23interactor260.84018.750Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
119 RPS25interactor260.87410.241Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
120 RPS3Ainteractor280.78822.703Ribosomal_S3Ae (PF01015, IPR001593): Ribosomal S3Ae family
121 RPS4Xinteractor280.77837.299KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
122 RPS7interactor230.9680.812Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
123 RPS9interactor240.9381.966Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
124 RSPO1oncoprotein100TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Furin-like_2 (PF15913, IPR006212): Furin-like repeat, cysteine-rich
125 S100A4interactor40.333813.102S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
126 SALL2suppressor100CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
127 SCARA3interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
128 SH2D4Ainteractor21.0000Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2039 (PF10217, IPR019351): Uncharacterized conserved protein (DUF2039)
129 SLC39A4suppressor100Zip (PF02535, IPR003689): ZIP Zinc transporter
Class_IIIsignal (PF04021, IPR007166): Class III signal peptide
130 SMARCE1interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
131 SNRPD3interactor21.0000LSM (PF01423, IPR001163): LSM domain
132 SPTAN1oncoprotein70.476855.449EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
133 STK26interactor200DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
134 SUPT6Hinteractor21.0000Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SH2_2 (PF14633, IPR000980): SH2 domain
HHH_7 (PF14635, IPR032706): Helix-hairpin-helix motif
YqgF (PF14639, IPR028231): Holliday-junction resolvase-like of SPT6
HTH_44 (PF14641, IPR028088): Helix-turn-helix DNA-binding domain of SPT6
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
DLD (PF14878, IPR027999): Death-like domain of SPT6
135 SYNE4interactor100KASH (PF10541, IPR012315): Nuclear envelope localisation domain
136 TBC1D27interactor100NA
137 TCERG1interactor41.0000FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
138 THRAsuppressor200C1_2 (PF03107, IPR004146): C1 domain
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
139 TOB2oncoprotein100PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
BTG (PF07742, IPR002087, SM00099): BTG family
140 TRMT10Cinteractor100tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
PPR_2 (PF13041, IPR002885): PPR repeat family
141 TSPOAP1oncoprotein200bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
ZapB (PF06005, IPR009252): Cell division protein ZapB
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SlyX (PF04102, IPR007236): SlyX
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
SH3_9 (PF14604, IPR001452): Variant SH3 domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
142 TSSC4suppressor21.0000TSSC4 (PF15264, IPR029338): Tumour suppressing sub-chromosomal transferable candidate 4
143 TTC21Ainteractor100MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
23S_rRNA_IVP (PF05635, IPR012657): 23S rRNA-intervening sequence protein
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain
RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
YgaB (PF14182, IPR025572): YgaB-like protein
TPR_19 (PF14559): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
SNAP (PF14938): Soluble NSF attachment protein, SNAP
144 TUBA1Binteractor50.7003.000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
145 TUBA4Ainteractor70.7143.400Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
146 TUBBprotein found in more fusions100.57811.467Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
147 TUBB2Ainteractor70.5249.500Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
148 TUBB4Binteractor80.6435.583Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
149 TUFT1interactor100USP8_interact (PF08941, IPR015036): USP8 interacting
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
150 TXNDC9interactor21.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
151 UBBinteractor100ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
152 UQCC2interactor100Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
153 UQCRBinteractor41.0000UCR_14kD (PF02271, IPR003197): Ubiquinol-cytochrome C reductase complex 14kD subunit
154 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
155 WDFY3interactor21.0000Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)
156 WIPI1interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
BCAS3 (PF12490, IPR022175): Breast carcinoma amplified sequence 3
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
157 XIAPinteractor50.1671509.883BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
158 YBX3interactor31.0000CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
159 ZACNinteractor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
160 ZBTB24interactor100AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zinc_ribbon_4 (PF13717): zinc-ribbon domain
161 ZMAT2interactor100Cgr1 (PF03879, IPR005579): Cgr1 family
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
162 ZNF804Binteractor100zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
163 ZNF85interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
ROS_MUCR (PF05443, IPR008807): ROS/MUCR transcriptional regulator protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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