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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins BTN2A1, DCAKD (from a repository: Mon May 8 08:02:32 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins6 (13.95 %)
The number (and %) of the tumor suppressors1 (2.33 %)
Total number of binary PPIs (saturation %)75 (8.31 %)
The number (and %) of affected PPIs41 (54.67 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI3.209
Assortativity coefficient-0.5797
The network average Clustering coefficient0.130
The number (and %) of a zero Clustering coefficients31 (72.09 %)
The number (and %) of a zero Betweenness Centrality19 (44.19 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DCAKD,BTN2A1 All fusions
Proteins found in more fusions PLCB1 (see 1 fusions); MCM2 (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DCAKDparental protein90.056249.396CoaE (PF01121, IPR001977): Dephospho-CoA kinase
2 BTN2A1parental protein320.0061359.677SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3169 (PF11368, IPR021509): Protein of unknown function (DUF3169)
DUF3213 (PF11491, IPR021583): Protein of unknown function (DUF3213)
Ig_3 (PF13927): Immunoglobulin domain
3 ATP2A3interactor3036.533Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
4 BLZF1interactor100DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
ZapB (PF06005, IPR009252): Cell division protein ZapB
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
5 BTN2A2interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
6 COQ9interactor200COQ9 (PF08511, IPR013718): COQ9
7 DAGLBinteractor100Lipase_3 (PF01764, IPR002921): Lipase (class 3)
8 DENND6Ainteractor2021.735SPA (PF08616): Stabilization of polarity axis
Avl9 (PF09794, IPR018307): Transport protein Avl9
9 DIP2Ainteractor2021.735AMP-binding (PF00501, IPR000873): AMP-binding enzyme
Cornifin (PF02389, IPR003302): Cornifin (SPRR) family
DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain
10 DLK1suppressor4046.804EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
11 ELAVL1oncoprotein80.09579.732RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 ESYT1interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
SMP_LBD (PF17047, IPR031468): Synaptotagmin-like mitochondrial-lipid-binding domain
13 FAM171A2interactor100UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
14 FAM189A2interactor6065.678CD20 (PF04103, IPR007237): CD20-like family
15 FAM189Binteractor30.33322.627CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
16 FMN2interactor21.0000ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
AAA_23 (PF13476): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
17 FOXS1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
18 HLA-DPA1interactor100MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
19 HMGCRoncoprotein4081.133HMG-CoA_red (PF00368, IPR002202): Hydroxymethylglutaryl-coenzyme A reductase
Sterol-sensing (PF12349, IPR000731): Sterol-sensing domain of SREBP cleavage-activation
20 ITFG2interactor21.0000BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
Itfg2 (PF15907, IPR031793): Integrin-alpha FG-GAP repeat-containing protein 2
21 KPTNinteractor30.6671.000AcetylCoA_hyd_C (PF13336, IPR026888): Acetyl-CoA hydrolase/transferase C-terminal domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
22 MARCH7interactor3047.140RINGv (PF12906, IPR011016, SM00744): RING-variant domain
23 MCM2oncoprotein31.0000AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
24 MCOLN3interactor4035.242PKD_channel (PF08016, IPR013122): Polycystin cation channel
25 ND1interactor100NA
26 OCRLinteractor2013.551Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
OCRL_clath_bd (PF16726, IPR031995): Inositol polyphosphate 5-phosphatase clathrin binding domain
27 OSBPinteractor2013.551Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
28 PDZD8interactor40.16743.697IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
29 PIK3R3interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
30 PLCB1oncoprotein200DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
31 PLEKHG4interactor100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
HET-s_218-289 (PF11558, IPR021084): Het-s 218-289
PH_10 (PF15411): Pleckstrin homology domain
32 PORinteractor2013.393FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
33 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
34 RAB3GAP1interactor100Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Rab3-GTPase_cat (PF13890, IPR026147): Rab3 GTPase-activating protein catalytic subunit
35 SGPL1interactor2013.551Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
36 SLC25A14interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
37 SLC25A30interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
38 SRPRBinteractor70.09566.966MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
39 TMEM214interactor2021.735TMEM214 (PF10151, IPR019308): TMEM214, C-terminal, caspase 4 activator
40 TMX4interactor2021.446DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Thioredoxin (PF00085, IPR013766): Thioredoxin
41 TYW1interactor3029.178Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
Radical_SAM (PF04055, IPR007197): Radical SAM superfamily
Wyosine_form (PF08608, IPR013917): Wyosine base formation
42 UBCprotein found in more fusions50.16760.235ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
43 UPK3BLinteractor4054.265PsbH (PF00737, IPR001056): Photosystem II 10 kDa phosphoprotein

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