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Fusion ID: Protein names:	79856 2395
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Visualization interactions

Cytoscape Web for: parental proteins FXN, SNX22 (from a repository: Wed Mar 3 07:10:57 2021)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	12
The number (and %) of the onco-proteins	4 (33.33 %)
The number (and %) of the tumor suppressors	1 (8.33 %)
Total number of binary PPIs (saturation %)	21 (31.82 %)
The number (and %) of affected PPIs	10 (47.62 %)
The number of possible different fusions	4
PPI diameter	5
PPI radius	3
The average degree of PPI	2.500
Assortativity coefficient	-0.0260
The network average Clustering coefficient	0.531
The number (and %) of a zero Clustering coefficients	3 (25.00 %)
The number (and %) of a zero Betweenness Centrality	7 (58.33 %)

ACTIVE INTERACTORS

List of the fusions
Proteins found in more fusions	DVL3 (see 1 fusions); ACTN1 (see 3 fusions); CSNK1E (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	SNX22	parental protein	6	0.200	63.000	PX (PF00787, IPR001683, SM00312): PX domain DUF4183 (PF13799, IPR025237): Domain of unknown function (DUF4183)
2	FXN	parental protein	4	0.167	52.000	Frataxin_Cyay (PF01491, IPR002908): Frataxin-like domain
3	ACTN1	protein found in more fusions	3	0	56.000	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
4	B3GALT2	interactor	1	0	0	Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
5	CSNK1A1	suppressor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
6	CSNK1E	protein found in more fusions	4	0.667	1.000	APH (PF01636, IPR002575): Phosphotransferase enzyme family Pkinase (PF00069, IPR000719): Protein kinase domain
7	DVL3	protein found in more fusions	3	1.000	0	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
8	LYRM4	interactor	3	1.000	0	Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
9	PICK1	oncoprotein	1	0	0	Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) KxDL (PF10241, IPR019371): Uncharacterized conserved protein
10	PMPCB	interactor	2	1.000	0	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
11	POT1	interactor	3	1.000	0	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
12	TERF2	interactor	4	0.333	60.000	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif

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