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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FXN, SNX22 (from a repository: Wed Mar 3 07:10:57 2021)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins4 (33.33 %)
The number (and %) of the tumor suppressors1 (8.33 %)
Total number of binary PPIs (saturation %)21 (31.82 %)
The number (and %) of affected PPIs10 (47.62 %)
The number of possible different fusions4
PPI diameter5
PPI radius3
The average degree of PPI2.500
Assortativity coefficient-0.0260
The network average Clustering coefficient0.531
The number (and %) of a zero Clustering coefficients3 (25.00 %)
The number (and %) of a zero Betweenness Centrality7 (58.33 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions DVL3 (see 1 fusions); ACTN1 (see 3 fusions); CSNK1E (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 SNX22parental protein60.20063.000PX (PF00787, IPR001683, SM00312): PX domain
DUF4183 (PF13799, IPR025237): Domain of unknown function (DUF4183)
2 FXNparental protein40.16752.000Frataxin_Cyay (PF01491, IPR002908): Frataxin-like domain
3 ACTN1protein found in more fusions3056.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 B3GALT2interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
5 CSNK1A1suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
6 CSNK1Eprotein found in more fusions40.6671.000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
7 DVL3protein found in more fusions31.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
8 LYRM4interactor31.0000Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
9 PICK1oncoprotein100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
10 PMPCBinteractor21.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
11 POT1interactor31.0000POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
12 TERF2interactor40.33360.000Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif

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