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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAM57A, ZFYVE26 (from a repository: Wed Aug 14 19:13:15 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins6 (26.09 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)44 (17.39 %)
The number (and %) of affected PPIs21 (47.73 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.870
Assortativity coefficient-0.3124
The network average Clustering coefficient0.528
The number (and %) of a zero Clustering coefficients8 (34.78 %)
The number (and %) of a zero Betweenness Centrality16 (69.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZFYVE26,FAM57A All fusions
Proteins found in more fusions HNRNPC (see 1 fusions); SSX2IP (see 1 fusions); ALAS1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZFYVE26parental protein190.070308.333FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
MerR-DNA-bind (PF09278, IPR015358): MerR, DNA binding
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
2 FAM57Aparental protein202.000TRAM_LAG1_CLN8 (PF03798, IPR006634): TLC domain
3 ALAS1protein found in more fusions200Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
Preseq_ALAS (PF09029, IPR015118): 5-aminolevulinate synthase presequence
4 CEP44interactor21.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Utp12 (PF04003, IPR007148): Dip2/Utp12 Family
CEP44 (PF15007, IPR029157): Centrosomal spindle body, CEP44
5 GOLGA2interactor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
6 HNRNPCprotein found in more fusions31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
7 KRT15interactor30.6670.667Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 KRT40interactor30.6670.667Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
9 KRTAP10-3interactor41.0000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
10 KRTAP10-7interactor50.6672.000Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
11 KRTAP10-9interactor41.0000Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
12 MAPK4oncoprotein100Pkinase (PF00069, IPR000719): Protein kinase domain
13 MDFIinteractor200MDFI (PF15316, IPR026134): MyoD family inhibitor
14 PNMA1oncoprotein21.0000PNMA (PF14893, IPR026523): PNMA
15 PNMA5interactor31.0000PNMA (PF14893, IPR026523): PNMA
16 SLC3A2interactor100Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain
DUF3459 (PF11941, IPR022567): Domain of unknown function (DUF3459)
SLC3A2_N (PF16028, IPR031984): Solute carrier family 3 member 2 N-terminus
17 SPAG5interactor21.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1307 (PF06998, IPR009736): Protein of unknown function (DUF1307)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
DUF3573 (PF12097, IPR021956): Protein of unknown function (DUF3573)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4266 (PF14086, IPR025362): Domain of unknown function (DUF4266)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
18 SSX2IPprotein found in more fusions60.4005.667ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
19 TADA2Ainteractor21.0000SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
20 TDO2interactor200Trp_dioxygenase (PF03301, IPR004981): Tryptophan 2,3-dioxygenase
21 TFIP11interactor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
GCFC (PF07842, IPR022783): GC-rich sequence DNA-binding factor-like protein
TIP_N (PF12457, IPR022159): Tuftelin interacting protein N terminal
22 TRAF1oncoprotein200HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
23 USHBP1interactor40.6670.667DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family

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