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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TAOK1, CCDC7 (from a repository: Thu Feb 22 13:17:22 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)18
The number (and %) of the onco-proteins8 (44.44 %)
The number (and %) of the tumor suppressors1 (5.56 %)
Total number of binary PPIs (saturation %)35 (22.88 %)
The number (and %) of affected PPIs16 (45.71 %)
The number of possible different fusions6
PPI diameter4
PPI radius3
The average degree of PPI3.000
Assortativity coefficient-0.3720
The network average Clustering coefficient0.300
The number (and %) of a zero Clustering coefficients8 (44.44 %)
The number (and %) of a zero Betweenness Centrality8 (44.44 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCDC7,TAOK1 All fusions
Proteins found in more fusions EWSR1 (see 2 fusions); ZDHHC17 (see 2 fusions); SNW1 (see 1 fusions); MAP3K7 (see 7 fusions); CSNK1E (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCDC7parental protein40.16716.500VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
TILa (PF12714, IPR025615): TILa domain
2 TAOK1parental protein120.061190.667Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Pkinase (PF00069, IPR000719): Protein kinase domain
PKK (PF12474, IPR022165): Polo kinase kinase
TcdB_N (PF12918, IPR024772): TcdB toxin N-terminal helical domain
3 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
4 CIAO1interactor206.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
5 CSNK1Eprotein found in more fusions31.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
6 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
7 EWSR1oncoprotein40.6675.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 GEMIN7interactor100Gemin7 (PF11095, IPR020338): Gem-associated protein 7 (Gemin7)
SUZ-C (PF12901, IPR024642): SUZ-C motif
9 MAP3K7oncoprotein200Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
10 NTRK1oncoprotein70.33345.500I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11 RAD21oncoprotein40.50010.333Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
12 SNW1protein found in more fusions50.33325.000SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
13 SRBD1interactor21.0000S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
HHH_3 (PF12836): Helix-hairpin-helix motif
DLD (PF14878, IPR027999): Death-like domain of SPT6
Tex_YqgF (PF16921, IPR032639): Tex protein YqgF-like domain
14 STK25interactor30.33314.000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
15 STK26interactor31.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
16 STK4oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
17 WT1suppressor2022.333WT1 (PF02165, IPR000976): Wilm's tumour protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
CCAP (PF11105, IPR024276): Arthropod cardioacceleratory peptide 2a
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
18 ZDHHC17protein found in more fusions4013.667zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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