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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)69
The number (and %) of the onco-proteins18 (26.09 %)
The number (and %) of the tumor suppressors11 (15.94 %)
Total number of binary PPIs (saturation %)220 (9.38 %)
The number (and %) of affected PPIs68 (30.91 %)
The number of possible different fusions13
PPI diameter5
PPI radius3
The average degree of PPI5.478
Assortativity coefficient-0.3509
The network average Clustering coefficient0.319
The number (and %) of a zero Clustering coefficients26 (37.68 %)
The number (and %) of a zero Betweenness Centrality28 (40.58 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCDC51,MAP2K4 All fusions
Proteins found in more fusions MAP3K7 (see 7 fusions); APP (see 5 fusions); MAP3K5 (see 1 fusions); LRRK2 (see 1 fusions); MAP3K2 (see 2 fusions); PML (see 4 fusions); RBBP8 (see 1 fusions); MAPK9 (see 3 fusions); MAP3K1 (see 1 fusions); MAPK1 (see 2 fusions); MAPK14 (see 1 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCDC51parental protein280.0082302.373XhlA (PF10779, IPR019715): Haemolysin XhlA
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
Helo_like_N (PF17111, IPR031348): Fungal N-terminal domain of STAND proteins
2 MAP2K4parental protein400.1471708.632Pkinase (PF00069, IPR000719): Protein kinase domain
3 AKT1oncoprotein130.40970.437PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 ALOX12Binteractor100Lipoxygenase (PF00305, IPR013819): Lipoxygenase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
5 APPprotein found in more fusions110.311445.782APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ARG1suppressor100Arginase (PF00491, IPR006035): Arginase family
7 ARRB1interactor120.54523.025Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
8 ARRB2interactor110.50928.695Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9 BLNKsuppressor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
10 CDC5Linteractor31.0000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
11 CDSNinteractor200Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
12 CEACAM21interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
13 CFTRsuppressor200ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
14 COQ9interactor31.0000COQ9 (PF08511, IPR013718): COQ9
15 CPA4interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
16 DUSP14interactor30.333258.827DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
17 ECM1oncoprotein100ECM1 (PF05782, IPR008605): Extracellular matrix protein 1 (ECM1)
18 EGFRoncoprotein140.321582.346Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
19 FABP5interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
20 FLNBoncoprotein40.6672.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
21 FLNCinteractor21.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
22 GCH1interactor31.0000GTP_cyclohydroI (PF01227, IPR020602): GTP cyclohydrolase I
23 GEMIN5interactor50.200281.826WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
24 GM2Ainteractor100E1_DerP2_DerF2 (PF02221, IPR003172, SM00737): ML domain
25 IGHG1oncoprotein20223.346C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
26 ITCHinteractor90.53615.279C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
27 JUNoncoprotein140.42358.808bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
28 JUPsuppressor30.333226.104Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
29 KPRPinteractor100Protamine_P1 (PF00260, IPR000221): Protamine P1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Defensin_like (PF10868, IPR022618): Cysteine-rich antifungal protein 2, defensin-like
30 KTI12interactor100KTI12 (PF08433, IPR013641): Chromatin associated protein KTI12
31 LRRK2oncoprotein60.4002.471Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
32 MAP2K6interactor80.32113.300Pkinase (PF00069, IPR000719): Protein kinase domain
33 MAP2K7interactor160.30093.786Pkinase (PF00069, IPR000719): Protein kinase domain
34 MAP3K1oncoprotein120.50934.181zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
35 MAP3K10interactor50.6674.179Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
36 MAP3K11interactor70.46714.133APG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
37 MAP3K2protein found in more fusions50.8330.333PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
38 MAP3K3oncoprotein80.38129.606PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
39 MAP3K4suppressor50.6670.952CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
40 MAP3K5oncoprotein110.37848.762Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
41 MAP3K7oncoprotein90.5007.257Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
42 MAP3K8suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
IML1 (PF12257, IPR027244): Vacuolar membrane-associated protein Iml1
43 MAP4K2oncoprotein30.6670.500CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
44 MAPK1oncoprotein110.48913.157Pkinase (PF00069, IPR000719): Protein kinase domain
45 MAPK10suppressor90.50027.553Pkinase (PF00069, IPR000719): Protein kinase domain
46 MAPK14oncoprotein110.42232.549Pkinase (PF00069, IPR000719): Protein kinase domain
47 MAPK8oncoprotein170.308184.242DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
48 MAPK8IP3interactor80.5716.738Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
49 MAPK9suppressor150.385633.838Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
50 MOV10interactor40.167239.409AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
51 NBR1oncoprotein40.6670.667CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
52 NCCRP1interactor100FBA (PF04300, IPR007397): F-box associated region
53 NEFHinteractor100DUF1388 (PF07142, IPR010790): Repeat of unknown function (DUF1388)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Filament (PF00038, IPR001664): Intermediate filament protein
54 NPHS1interactor31.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4643 (PF15485, IPR028004): Domain of unknown function (DUF4643)
55 NXF1interactor50.167183.590NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
56 PKP1interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
57 PKP3interactor30.333255.182Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
58 PLBD1interactor20164.409Phospholip_B (PF04916, IPR007000): Phospholipase B
59 PMLsuppressor50.6674.422zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
60 POF1Binteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
61 RBBP8suppressor200ZapB (PF06005, IPR009252): Cell division protein ZapB
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
62 SERPINB2interactor20164.409Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
63 SPAG9interactor40.5001.167DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IncA (PF04156, IPR007285): IncA protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
64 TGM1interactor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
65 TGM3suppressor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
66 TGM5interactor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
67 VASPinteractor40183.725ASD2 (PF08687, IPR014799): Apx/Shroom domain ASD2
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
68 WDFY2interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
69 YOD1interactor100OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain

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