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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)86
The number (and %) of the onco-proteins22 (25.58 %)
The number (and %) of the tumor suppressors14 (16.28 %)
Total number of binary PPIs (saturation %)258 (7.06 %)
The number (and %) of affected PPIs85 (32.95 %)
The number of possible different fusions12
PPI diameter5
PPI radius3
The average degree of PPI5.256
Assortativity coefficient-0.2386
The network average Clustering coefficient0.456
The number (and %) of a zero Clustering coefficients26 (30.23 %)
The number (and %) of a zero Betweenness Centrality43 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CCDC51,MYD88 All fusions
Proteins found in more fusions TRAF6 (see 1 fusions); SYK (see 1 fusions); PRDX1 (see 1 fusions); IRF7 (see 1 fusions); PFKL (see 2 fusions); SIAH2 (see 1 fusions); MAP3K7 (see 7 fusions); SQSTM1 (see 5 fusions); RAC1 (see 2 fusions); CBLB (see 4 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CCDC51parental protein280.0083180.743XhlA (PF10779, IPR019715): Haemolysin XhlA
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
Helo_like_N (PF17111, IPR031348): Fungal N-terminal domain of STAND proteins
2 MYD88parental protein570.0843564.921Death (PF00531, IPR000488, SM00005): Death domain
TIR (PF01582, IPR000157, SM00255): TIR domain
3 ALOX12Binteractor100Lipoxygenase (PF00305, IPR013819): Lipoxygenase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
4 ARG1suppressor100Arginase (PF00491, IPR006035): Arginase family
5 BST2oncoprotein21.0000DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
6 BTKsuppressor80.6196.860BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 CBLBoncoprotein60.7000.868Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
PRIMA1 (PF16101): Proline-rich membrane anchor 1
8 CD93interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Plasmod_Pvs28 (PF06247, IPR010423): Pvs28 EGF domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
9 CDSNinteractor200Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
10 CEACAM21interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
11 CFTRsuppressor50.167608.785ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
12 CISHinteractor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
ER-remodelling (PF14755, IPR032786): Intracellular membrane remodeller
SOCS_box (PF07525, IPR001496): SOCS box
13 COQ9interactor31.0000COQ9 (PF08511, IPR013718): COQ9
14 CPA4interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
15 CYLDsuppressor70.61920.474CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-HIT (PF04438, IPR007529): HIT zinc finger
CYLD_phos_site (PF16607): Phosphorylation region of CYLD, unstructured
16 DUSP14interactor21.0000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
17 ECM1oncoprotein20217.278ECM1 (PF05782, IPR008605): Extracellular matrix protein 1 (ECM1)
18 FABP5interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
19 FADDsuppressor50.300294.352Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
20 FLIIoncoprotein30.6675.900Gelsolin (PF00626, IPR007123): Gelsolin repeat
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 GM2Ainteractor100E1_DerP2_DerF2 (PF02221, IPR003172, SM00737): ML domain
22 HDAC6oncoprotein90.286485.751Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
23 IGHG1oncoprotein100C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
24 IKBKEinteractor60.8001.167IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
25 IKBKGinteractor140.41095.988CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
26 IL1R1interactor70.8102.167TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
27 IL1RAPinteractor50.6008.733ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
28 IL1RL1interactor41.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
TIR (PF01582, IPR000157, SM00255): TIR domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
29 IRAK1interactor240.2611124.199Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
30 IRAK2oncoprotein100.62216.265Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
31 IRAK3interactor60.667276.111Death (PF00531, IPR000488, SM00005): Death domain
Pkinase (PF00069, IPR000719): Protein kinase domain
32 IRAK4interactor130.50023.367Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
33 IRF4suppressor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
34 IRF5suppressor31.0000IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
35 IRF7protein found in more fusions60.5005.138IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
36 JUPsuppressor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
37 KPRPinteractor100Protamine_P1 (PF00260, IPR000221): Protamine P1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Defensin_like (PF10868, IPR022618): Cysteine-rich antifungal protein 2, defensin-like
38 LRRFIP1oncoprotein21.0000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Rxt3 (PF08642, IPR013951): Histone deacetylation protein Rxt3
LRRFIP (PF09738, IPR019139): LRRFIP family
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
Coilin_N (PF15862, IPR031722): Coilin N-terminus
39 LRRFIP2interactor30.333176.446TACC (PF05010, IPR007707): Transforming acidic coiled-coil-containing protein (TACC)
LRRFIP (PF09738, IPR019139): LRRFIP family
40 MALsuppressor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
41 MAP3K7oncoprotein140.34651.747Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
42 MBIPinteractor31.0000DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
43 MDM2oncoprotein40.6670.400Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
44 MOV10interactor30.333273.734AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
45 NCCRP1interactor100FBA (PF04300, IPR007397): F-box associated region
46 NEFHinteractor20235.905DUF1388 (PF07142, IPR010790): Repeat of unknown function (DUF1388)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Filament (PF00038, IPR001664): Intermediate filament protein
47 NXF1interactor60.3001416.851NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
48 PELI1interactor70.7628.967Pellino (PF04710, IPR006800): Pellino
49 PFKLprotein found in more fusions31.0000PFK (PF00365, IPR000023): Phosphofructokinase
50 PKP1interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
51 PKP3interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
52 PLBD1interactor100Phospholip_B (PF04916, IPR007000): Phospholipase B
53 POF1Binteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
54 POLR1Cinteractor21.0000RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
55 PRDX1oncoprotein31.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
56 RAC1oncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
57 SARM1interactor41.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Carb_kinase (PF01256, IPR000631): Carbohydrate kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
HEAT_2 (PF13646): HEAT repeats
TIR_2 (PF13676, IPR000157): TIR domain
58 SASH1suppressor50.9000.333PGA2 (PF07543, IPR011431): Protein trafficking PGA2
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
SLY (PF12485, IPR021090): Lymphocyte signaling adaptor protein
59 SERPINB2interactor100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
60 SIAH1suppressor40.6671.000Sina (PF03145, IPR018121): Seven in absentia protein family
61 SIAH2oncoprotein31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
62 SMAD3oncoprotein80.28621.241MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
63 SMAD6interactor40.5001.567MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
64 SMURF1interactor70.3335.701C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
65 SPOPsuppressor40.6671.000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
MATH (PF00917, IPR002083, SM00061): MATH domain
66 SQSTM1oncoprotein110.333800.869PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
67 STAP2interactor100SH2 (PF00017, IPR000980, SM00252): SH2 domain
68 SYKsuppressor110.51130.515Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
69 TGM1interactor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
70 TGM3suppressor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
71 TGM5interactor100Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
72 TIRAPinteractor110.53311.538TIR_2 (PF13676, IPR000157): TIR domain
73 TLR2interactor41.0000LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
74 TLR3interactor60.7332.248LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
75 TLR4interactor90.52811.050LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
76 TLR5interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
77 TLR7interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
78 TLR9interactor60.6673.898LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
TIR (PF01582, IPR000157, SM00255): TIR domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
79 TNFRSF13Boncoprotein50.7003.379TACI-CRD2 (PF09305, IPR015384): TACI, cysteine-rich domain
80 TNIP1interactor51.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
FlxA (PF14282, IPR025577): FlxA-like protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
81 TRAF3oncoprotein140.29536.052ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
Spc29 (PF17082, IPR031392): Spindle Pole Component 29
82 TRAF6protein found in more fusions270.218292.195SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
83 TXNoncoprotein30.6671.000Thioredoxin (PF00085, IPR013766): Thioredoxin
84 USP7oncoprotein90.32137.298MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
85 WDFY2interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
86 YOD1interactor100OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain

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