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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KDM2A, C11orf80 (from a repository: Wed Apr 26 12:39:10 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)31
The number (and %) of the onco-proteins13 (41.94 %)
The number (and %) of the tumor suppressors3 (9.68 %)
Total number of binary PPIs (saturation %)63 (13.55 %)
The number (and %) of affected PPIs29 (46.03 %)
The number of possible different fusions5
PPI diameter2
PPI radiusinf
The average degree of PPI3.355
Assortativity coefficient-0.3959
The network average Clustering coefficient0.550
The number (and %) of a zero Clustering coefficients9 (29.03 %)
The number (and %) of a zero Betweenness Centrality21 (67.74 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: KDM2A,C11orf80 All fusions
Proteins found in more fusions BCL6 (see 2 fusions); FOS (see 4 fusions); PSMB3 (see 1 fusions); RANGAP1 (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 KDM2Aparental protein290.057728.000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
DZR (PF12773, IPR025874): Double zinc ribbon
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
2 C11orf80interactor000DUF4554 (PF15091, IPR028040): Domain of unknown function (DUF4554)
3 ACTR1Binteractor100Actin (PF00022, IPR004000, SM00268): Actin
4 ARHGEF7interactor100Borrelia_lipo_1 (PF05714, IPR008421): Borrelia burgdorferi virulent strain associated lipoprotein
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
RhoGEF67_u2 (PF16614): Unstructured region two on RhoGEF 6 and 7
RhoGEF67_u1 (PF16615): Unstructured region one on RhoGEF 6 and 7
5 BCL6oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
6 CBX4oncoprotein60.5005.000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
7 E2F1suppressor21.0000Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
8 EEDsuppressor60.6004.000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 ELAVL1oncoprotein80.33314.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 FOSoncoprotein50.6672.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
11 HIST1H2BGoncoprotein50.4006.000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
12 HIST2H3Cinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HIST3H3interactor31.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 KIAA0368interactor21.0000HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
15 KIF20Binteractor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
YlqD (PF11068, IPR021297): YlqD protein
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
16 KRASoncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
17 MPGinteractor21.0000Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
18 PPP1R2interactor30.6671.000IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
19 PSMB3protein found in more fusions200Proteasome (PF00227, IPR001353): Proteasome subunit
20 RAB5Concoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
21 RANGAP1protein found in more fusions31.0000RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
22 RB1suppressor40.5003.000RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
23 RBPJinteractor30.6671.000BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
24 REEP5interactor100Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
TB2_DP1_HVA22 (PF03134, IPR004345): TB2/DP1, HVA22 family
25 RELAoncoprotein41.0000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
26 SKP1oncoprotein31.0000Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
27 SMAD3oncoprotein50.6672.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
28 SMAD7interactor21.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
29 STAG2oncoprotein100AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
STAG (PF08514, IPR013721): STAG domain
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
30 UBE2G2interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 ZNF512Binteractor21.0000YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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