Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MAZ, ADIPOR2 (from a repository: Fri Aug 16 00:06:48 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins7 (36.84 %)
The number (and %) of the tumor suppressors1 (5.26 %)
Total number of binary PPIs (saturation %)42 (24.56 %)
The number (and %) of affected PPIs17 (40.48 %)
The number of possible different fusions5
PPI diameter5
PPI radius3
The average degree of PPI3.368
Assortativity coefficient-0.1928
The network average Clustering coefficient0.411
The number (and %) of a zero Clustering coefficients8 (42.11 %)
The number (and %) of a zero Betweenness Centrality7 (36.84 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MAZ,ADIPOR2 All fusions
Proteins found in more fusions EWSR1 (see 1 fusions); FOS (see 4 fusions); CSNK2A1 (see 2 fusions); MAPK14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MAZparental protein120.167187.667zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
2 ADIPOR2parental protein5076.000HlyIII (PF03006, IPR004254): Haemolysin-III related
PRR18 (PF15671, IPR031369): Proline-rich protein family 18
3 APPL1interactor3015.500ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
PH (PF00169, IPR001849, SM00233): PH domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
BAR_3 (PF16746): BAR domain of APPL family
4 BPTFinteractor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
DDT (PF02791, IPR004022, SM00571): DDT domain
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GRP (PF07172, IPR010800): Glycine rich protein family
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
SDA1 (PF05285, IPR007949): SDA1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
5 CSNK2A1oncoprotein80.38121.667Pkinase (PF00069, IPR000719): Protein kinase domain
6 DCCsuppressor3069.000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neogenin_C (PF06583, IPR010560): Neogenin C-terminus
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
7 EWSR1oncoprotein40.6670.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
8 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
9 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
10 JUNoncoprotein60.6003.333bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
11 KEAP1oncoprotein31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
12 MAPK14oncoprotein41.0000Pkinase (PF00069, IPR000719): Protein kinase domain
13 MOV10interactor2019.833AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
14 NCK1oncoprotein2015.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
15 NXF1interactor40.33337.167NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
16 OTUB1interactor30.6670.667Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
17 RNF181interactor200AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
18 TCTN2interactor100DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
19 TCTN3interactor3053.000DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)

B a c k    t o    T o p ⇑