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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ERI3, FUNDC1 (from a repository: Thu Dec 5 16:22:11 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins4 (20.00 %)
The number (and %) of the tumor suppressors1 (5.00 %)
Total number of binary PPIs (saturation %)29 (15.26 %)
The number (and %) of affected PPIs18 (62.07 %)
The number of possible different fusions4
PPI diameter2
PPI radiusinf
The average degree of PPI2.300
Assortativity coefficient-0.2371
The network average Clustering coefficient0.236
The number (and %) of a zero Clustering coefficients13 (65.00 %)
The number (and %) of a zero Betweenness Centrality14 (70.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FUNDC1,ERI3 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); CTBP2 (see 2 fusions); SNX1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FUNDC1parental protein150.048197.333FUN14 (PF04930, IPR007014): FUN14 family
2 ERI3parental protein306.000RNase_T (PF00929, IPR013520): Exonuclease
3 CENPOinteractor100CENP-O (PF09496, IPR018464): Cenp-O kinetochore centromere component
Takusan (PF04822, IPR006907): Takusan
MnmE_helical (PF12631, IPR025867): MnmE helical domain
4 CTBP1protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
5 CTBP2protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
6 EHHADHinteractor1002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
3HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
7 FUNDC2interactor200FUN14 (PF04930, IPR007014): FUN14 family
8 GABARAPL1interactor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
9 GABARAPL2interactor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
10 MAP1LC3Ainteractor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
11 MAP1LC3Binteractor30.6670.667Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
12 MTERF3interactor100mTERF (PF02536, IPR003690, SM00733): mTERF
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
13 RAPGEF2interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
14 SENP2interactor100Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
15 SH3GLB1suppressor200BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
16 SLC25A46interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
17 SNX1protein found in more fusions200PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
18 TTKinteractor200Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
Pkinase (PF00069, IPR000719): Protein kinase domain
RIO1 (PF01163, IPR018934): RIO1 family
T3SS_basalb_I (PF17001, IPR012670): Type III secretion basal body protein I, YscI, HrpB, PscI
Mad3_BUB1_I_2 (PF17014, IPR031522): Putative Mad3/BUB1 like region 1 protein
19 TUFMinteractor100GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
20 YES1oncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain

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