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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins PXDN, WNT9A (from a repository: Mon Jul 29 21:58:13 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)14
The number (and %) of the onco-proteins3 (21.43 %)
The number (and %) of the tumor suppressors1 (7.14 %)
Total number of binary PPIs (saturation %)16 (17.58 %)
The number (and %) of affected PPIs12 (75.00 %)
The number of possible different fusions1
PPI diameter2
PPI radiusinf
The average degree of PPI1.857
Assortativity coefficient-0.5270
The network average Clustering coefficient0.144
The number (and %) of a zero Clustering coefficients11 (78.57 %)
The number (and %) of a zero Betweenness Centrality13 (92.86 %)


List of the fusions

PPI for parental proteins: WNT9A,PXDN All fusions
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 WNT9Ainteractor000wnt (PF00110, IPR005817, SM00097): wnt family
2 PXDNparental protein120.015130.000An_peroxidase (PF03098, IPR002007): Animal haem peroxidase
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
TILa (PF12714, IPR025615): TILa domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
3 ADCYAP1interactor100Hormone_2 (PF00123, IPR000532, SM00070): Peptide hormone
4 BNIPLinteractor200BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
5 CD96interactor100C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
6 CNPY3interactor100DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP
7 FBXO6interactor100FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
8 FGL1interactor100Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
9 HECW2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
10 NTRK1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
11 PLAURoncoprotein100Toxin_1 (PF00087, IPR003571): Snake toxin
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
12 PTPRKsuppressor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
13 SCARA3interactor100Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Filament (PF00038, IPR001664): Intermediate filament protein
Flagellin_C (PF00700, IPR001029): Bacterial flagellin C-terminal helical region
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
14 SPTAN1oncoprotein21.0000EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain

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