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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TAOK1, ZNF217 (from a repository: Mon Feb 5 04:58:36 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)25
The number (and %) of the onco-proteins10 (40.00 %)
The number (and %) of the tumor suppressors3 (12.00 %)
Total number of binary PPIs (saturation %)81 (27.00 %)
The number (and %) of affected PPIs23 (28.40 %)
The number of possible different fusions8
PPI diameter5
PPI radius3
The average degree of PPI5.360
Assortativity coefficient-0.4236
The network average Clustering coefficient0.467
The number (and %) of a zero Clustering coefficients7 (28.00 %)
The number (and %) of a zero Betweenness Centrality7 (28.00 %)


List of the fusions

PPI for parental proteins: ZNF217,TAOK1 All fusions
Proteins found in more fusions KDM1A (see 2 fusions); CSNK1E (see 1 fusions); CTBP1 (see 2 fusions); RCOR1 (see 2 fusions); CTBP2 (see 2 fusions); MAP3K7 (see 7 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ZNF217parental protein110.54565.343zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2256 (PF10013, IPR017136): Uncharacterized protein conserved in bacteria (DUF2256)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
HiaBD2 (PF15403, IPR029275): HiaBD2_N domain of Trimeric autotransporter adhesin (GIN)
2 TAOK1parental protein120.061241.000Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD)
Pkinase (PF00069, IPR000719): Protein kinase domain
PKK (PF12474, IPR022165): Polo kinase kinase
TcdB_N (PF12918, IPR024772): TcdB toxin N-terminal helical domain
3 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
4 CSNK1Eprotein found in more fusions40.6675.733APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 CTBP1protein found in more fusions110.62247.9522-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
6 CTBP2protein found in more fusions70.9330.3332-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
7 DYNC1I1interactor100CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
8 EHMT2interactor70.9330.333CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
9 ELAVL1oncoprotein110.244122.838RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 GEMIN7interactor100Gemin7 (PF11095, IPR020338): Gem-associated protein 7 (Gemin7)
SUZ-C (PF12901, IPR024642): SUZ-C motif
11 HDAC1suppressor90.7862.733FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
12 HDAC2suppressor130.53090.019Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
13 HIST3H3interactor70.9050.667Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
14 KDM1Aprotein found in more fusions80.76214.710Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
15 KDM5Binteractor60.8005.710ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein
16 MAP3K7oncoprotein200Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
17 NTRK1oncoprotein90.429116.395I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
18 PIPOXinteractor100DAO (PF01266, IPR006076): FAD dependent oxidoreductase
19 RCOR1protein found in more fusions90.7862.733DivIC (PF04977, IPR007060): Septum formation initiator
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
FAM76 (PF16046, IPR032017): FAM76 protein
20 SNW1protein found in more fusions50.66735.633SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
21 SRBD1interactor30.6675.733S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
HHH_3 (PF12836): Helix-hairpin-helix motif
DLD (PF14878, IPR027999): Death-like domain of SPT6
Tex_YqgF (PF16921, IPR032639): Tex protein YqgF-like domain
22 STK25interactor21.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
23 STK26interactor40.33320.400DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
24 STK4oncoprotein305.733Pkinase (PF00069, IPR000719): Protein kinase domain
Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
25 WT1suppressor100WT1 (PF02165, IPR000976): Wilm's tumour protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
CCAP (PF11105, IPR024276): Arthropod cardioacceleratory peptide 2a
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain

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