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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GATA3, ZNF133 (from a repository: Fri Nov 22 21:05:39 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins14 (48.28 %)
The number (and %) of the tumor suppressors8 (27.59 %)
Total number of binary PPIs (saturation %)81 (19.95 %)
The number (and %) of affected PPIs28 (34.57 %)
The number of possible different fusions8
PPI diameter4
PPI radius2
The average degree of PPI4.207
Assortativity coefficient-0.3336
The network average Clustering coefficient0.479
The number (and %) of a zero Clustering coefficients5 (17.24 %)
The number (and %) of a zero Betweenness Centrality9 (31.03 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZNF133,GATA3 All fusions
Proteins found in more fusions FOS (see 4 fusions); MAPK14 (see 1 fusions); ILK (see 2 fusions); HDAC5 (see 1 fusions); TRIM28 (see 1 fusions); HDAC4 (see 1 fusions); SP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZNF133parental protein70.143126.676zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
2 GATA3parental protein210.110429.111GATA (PF00320, IPR000679, SM00401): GATA zinc finger
Vps36-NZF-N (PF16988, IPR031558): Vacuolar protein sorting 36 NZF-N zinc-finger domain
3 BMI1oncoprotein50.33313.026zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
4 BRCA1suppressor41.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
5 CDK2suppressor60.40022.371Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
6 FBXW7suppressor40.6670.667Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
7 FOSoncoprotein308.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 FOXP3suppressor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
9 HDAC3suppressor90.35740.443Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
10 HDAC4oncoprotein60.6004.611Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
11 HDAC5protein found in more fusions50.6678.698Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
12 ILKsuppressor40.66710.533Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
13 KRTAP10-7interactor3013.756Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
14 LMO1oncoprotein21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
15 LMO2oncoprotein50.50038.200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
16 MAPK14oncoprotein50.6671.500Pkinase (PF00069, IPR000719): Protein kinase domain
17 MAPK6oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
18 MDM2oncoprotein50.33367.813Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
19 MYBoncoprotein30.3338.226Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
20 PDPK1interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
PH_3 (PF14593): PH domain
21 PSMA3interactor31.0000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
22 RARBsuppressor100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 REPIN1interactor30.6670.500zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
24 SP1protein found in more fusions100.33330.956zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
25 SPI1suppressor30.33334.333Ets (PF00178, IPR000418, SM00413): Ets-domain
p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
26 TAL1oncoprotein50.6673.000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
27 TBX21oncoprotein21.0000T-box (PF00907, IPR001699, SM00425): T-box
T-box_assoc (PF16176, IPR032385): T-box transcription factor-associated
28 TRIM28protein found in more fusions90.107111.579ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
29 USP21interactor200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase

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