Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins GOSR1, YES1 (from a repository: Fri Jul 26 06:14:36 2019)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 112 The number (and %) of the onco-proteins 29 (25.89 %) The number (and %) of the tumor suppressors 14 (12.50 %) Total number of binary PPIs (saturation %) 472 (7.59 %) The number (and %) of affected PPIs 111 (23.52 %) The number of possible different fusions 19 PPI diameter 4 PPI radius 2 The average degree of PPI 7.768 Assortativity coefficient -0.3494 The network average Clustering coefficient 0.455 The number (and %) of a zero Clustering coefficients 14 (12.50 %) The number (and %) of a zero Betweenness Centrality 28 (25.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: GOSR1,YES1	All fusions
Proteins found in more fusions	TRAF6 (see 1 fusions); CDH1 (see 3 fusions); APP (see 5 fusions); KHDRBS1 (see 1 fusions); MAPRE1 (see 1 fusions); HSP90AA1 (see 6 fusions); EGFR (see 2 fusions); EPHB2 (see 1 fusions); BECN1 (see 1 fusions); CUL7 (see 2 fusions); TNK2 (see 1 fusions); PTK2 (see 3 fusions); FXR2 (see 1 fusions); SLC9A3R1 (see 2 fusions); FYN (see 1 fusions); SLC25A11 (see 1 fusions); NEDD4 (see 1 fusions); MYC (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GOSR1	parental protein	26	0.231	808.882	V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
2	YES1	parental protein	85	0.052	7548.862	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain YdjC (PF04794, IPR006879): YdjC-like protein SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3	ACSL3	oncoprotein	5	0.400	20.223	AMP-binding (PF00501, IPR000873): AMP-binding enzyme AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
4	ADAM15	interactor	2	1.000	0	CD20 (PF04103, IPR007237): CD20-like family Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
5	ANKRD12	oncoprotein	2	1.000	0	CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) UPF0767 (PF15990, IPR031933): UPF0767 family PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
6	ANLN	oncoprotein	7	0.714	3.047	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
7	APP	protein found in more fusions	25	0.105	678.714	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8	ARRB1	interactor	11	0.291	82.849	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9	ATAD1	interactor	5	0.400	23.525	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) PhoH (PF02562, IPR003714): PhoH-like protein DUF3240 (PF11582, IPR021634): Protein of unknown function (DUF3240) AAA_18 (PF13238): AAA domain
10	ATP6AP2	interactor	7	0.533	12.526	Phosphodiest (PF01663, IPR002591): Type I phosphodiesterase / nucleotide pyrophosphatase Renin_r (PF07850, IPR012493): Renin receptor-like protein
11	ATP6V1E1	interactor	3	0.333	21.154	vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
12	BECN1	suppressor	5	0.500	1.086	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
13	BET1	interactor	7	0.810	2.857	Use1 (PF09753, IPR019150): Membrane fusion protein Use1
14	BET1L	interactor	6	0.733	9.011	CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
15	C1orf94	interactor	3	0	34.457	DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
16	CBL	suppressor	10	0.389	23.730	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
17	CCNL2	interactor	2	1.000	0	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
18	CCR1	oncoprotein	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
19	CD36	interactor	3	0.333	7.318	CD36 (PF01130, IPR002159): CD36 family
20	CD46	oncoprotein	1	0	0	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) DUF3188 (PF11384, IPR021524): Protein of unknown function (DUF3188) ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
21	CDH1	suppressor	7	0.667	3.378	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
22	CLEC12A	interactor	3	1.000	0	Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
23	CSF1R	oncoprotein	6	0.533	3.419	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
24	CTNND1	suppressor	8	0.357	59.113	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2 Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
25	CUL7	protein found in more fusions	13	0.288	95.437	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
26	CYP51A1	interactor	3	0.667	0.402	p450 (PF00067, IPR001128): Cytochrome P450
27	DBN1	oncoprotein	10	0.556	15.208	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
28	DOK1	suppressor	5	0.667	3.763	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
29	DSC1	interactor	2	1.000	0	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114 Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
30	DVL2	interactor	8	0.333	17.223	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
31	DYNLT1	interactor	4	0.333	13.912	Tctex-1 (PF03645, IPR005334): Tctex-1 family
32	EGFR	oncoprotein	26	0.157	557.604	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
33	ELAVL1	oncoprotein	25	0.145	560.472	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34	EPHB2	suppressor	3	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
35	FAF2	interactor	6	0.400	39.498	DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682) UBX (PF00789, IPR001012, SM00166): UBX domain Thioredoxin_7 (PF13899): Thioredoxin-like UBA_4 (PF14555): UBA-like domain
36	FASLG	interactor	3	0.667	0.957	PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1
37	FLOT1	interactor	12	0.288	183.101	CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family Flot (PF15975, IPR031905): Flotillin
38	FN1	oncoprotein	18	0.229	323.498	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39	FUNDC1	interactor	1	0	0	FUN14 (PF04930, IPR007014): FUN14 family
40	FXR2	protein found in more fusions	7	0.400	20.047	Agenet (PF05641, IPR008395, SM00743): Agenet domain REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein) KH_1 (PF00013, IPR004088, SM00322): KH domain FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
41	FYN	oncoprotein	29	0.101	357.496	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
42	FYTTD1	interactor	2	0	0	FYTT (PF07078, IPR009782): Forty-two-three protein
43	GPR35	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
44	GRPEL2	interactor	2	1.000	0	GrpE (PF01025, IPR000740): GrpE GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
45	HNRNPH1	oncoprotein	10	0.356	105.305	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
46	HOXB5	interactor	2	1.000	0	DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
47	HSP90AA1	oncoprotein	16	0.314	92.055	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
48	ILF2	interactor	7	0.524	33.334	DZF (PF07528, IPR006561, SM00572): DZF domain
49	JSRP1	interactor	1	0	0	SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein PRIMA1 (PF16101): Proline-rich membrane anchor 1
50	KHDRBS1	protein found in more fusions	7	0.267	68.137	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
51	KIT	oncoprotein	3	0.667	0.667	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
52	LIMA1	suppressor	14	0.363	85.984	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
53	LIMCH1	interactor	6	0.533	14.185	LIM (PF00412, IPR001781, SM00132): LIM domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor DUF3435 (PF11917, IPR021842): Protein of unknown function (DUF3435) DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
54	MAPRE1	oncoprotein	8	0.381	18.775	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
55	MED28	interactor	4	0.667	1.189	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain Med28 (PF11594, IPR021640): Mediator complex subunit 28
56	MYC	oncoprotein	10	0.278	220.201	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
57	MYH9	suppressor	15	0.343	127.668	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
58	NEDD4	suppressor	10	0.333	19.645	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
59	NFKBIA	oncoprotein	4	0.667	1.167	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
60	NIF3L1	interactor	4	1.000	0	NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
61	NPHS1	interactor	3	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain DUF4643 (PF15485, IPR028004): Domain of unknown function (DUF4643)
62	NSF	interactor	11	0.511	83.548	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2 CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain ATPase (PF06745, IPR014774): KaiC AAA_19 (PF13245): AAA domain
63	NSUN2	interactor	3	0.667	1.389	Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
64	OCLN	interactor	3	0.333	13.289	MARVEL (PF01284, IPR008253): Membrane-associating domain Occludin_ELL (PF07303, IPR010844): Occludin homology domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
65	OGT	interactor	4	0.500	2.500	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41 TPR_19 (PF14559): Tetratricopeptide repeat
66	OLIG1	interactor	2	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Metal_resist (PF13801, IPR025961): Heavy-metal resistance
67	PAN2	interactor	10	0.422	20.614	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
68	PDCD6IP	interactor	6	0.700	2.196	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
69	PDLIM7	interactor	6	0.400	9.120	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
70	PECAM1	oncoprotein	3	1.000	0	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
71	PHB2	interactor	5	0.600	7.589	DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
72	PIFO	interactor	1	0	0	SHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
73	PKP1	interactor	3	0.333	50.759	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
74	PPP1CB	interactor	11	0.436	30.083	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
75	PTEN	suppressor	10	0.311	26.082	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
76	PTK2	protein found in more fusions	12	0.436	33.181	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
77	PTPN1	suppressor	6	0.200	27.955	Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
78	RAB5C	oncoprotein	12	0.273	97.391	Ras (PF00071, IPR001806, SM00173): Ras family
79	RASA1	oncoprotein	9	0.333	58.762	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
80	RPL10	suppressor	8	0.321	20.481	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
81	SCFD1	interactor	12	0.394	84.021	Sec1 (PF00995, IPR001619): Sec1 family
82	SEC22B	interactor	8	0.393	42.157	Synaptobrevin (PF00957, IPR001388): Synaptobrevin Longin (PF13774, IPR010908): Regulated-SNARE-like domain
83	SLC16A14	interactor	1	0	0	MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
84	SLC25A11	protein found in more fusions	5	0.500	3.445	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
85	SLC25A41	interactor	2	1.000	0	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
86	SLC30A4	interactor	1	0	0	Cation_efflux (PF01545, IPR002524): Cation efflux family
87	SLC9A3R1	suppressor	3	1.000	0	EBP50_C (PF09007, IPR015098): EBP50, C-terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
88	SNAP23	interactor	15	0.407	387.667	DivIC (PF04977, IPR007060): Septum formation initiator DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 SNAP-25 (PF00835, IPR000928): SNAP-25 family DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
89	SNAP25	interactor	6	0.600	17.345	SNAP-25 (PF00835, IPR000928): SNAP-25 family Use1 (PF09753, IPR019150): Membrane fusion protein Use1
90	SOCS3	suppressor	9	0.417	33.594	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
91	SPRR2A	interactor	1	0	0	SPRR2 (PF14820, IPR029142): Small proline-rich 2
92	SSBP3	oncoprotein	2	0	4.483	SSDP (PF04503): Single-stranded DNA binding protein, SSDP
93	STX12	interactor	13	0.513	119.029	PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal SNARE (PF05739, IPR000727, SM00397): SNARE domain DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776) Syntaxin_2 (PF14523): Syntaxin-like protein
94	STX3	interactor	8	0.500	43.551	XhlA (PF10779, IPR019715): Haemolysin XhlA Syntaxin (PF00804, IPR006011, SM00503): Syntaxin SNARE (PF05739, IPR000727, SM00397): SNARE domain
95	STX5	interactor	17	0.463	110.837	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Syntaxin-18_N (PF10496, IPR019529): SNARE-complex protein Syntaxin-18 N-terminus Syntaxin (PF00804, IPR006011, SM00503): Syntaxin SNARE (PF05739, IPR000727, SM00397): SNARE domain Syntaxin-5_N (PF11416, IPR021538): Syntaxin-5 N-terminal, Sly1p-binding domain
96	STX6	interactor	11	0.655	55.261	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal SNARE (PF05739, IPR000727, SM00397): SNARE domain
97	STX7	interactor	13	0.551	59.658	SNARE (PF05739, IPR000727, SM00397): SNARE domain Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 Syntaxin_2 (PF14523): Syntaxin-like protein
98	THAP1	interactor	6	0.300	19.480	THAP (PF05485, IPR006612, SM00980): THAP domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
99	TMEM17	interactor	19	0.263	830.270	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
100	TMEM185A	interactor	3	0.333	67.186	Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
101	TMEM216	interactor	19	0.263	203.974	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
102	TNFSF11	interactor	1	0	0	TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family DUF2735 (PF10931, IPR021232): Protein of unknown function (DUF2735)
103	TNK2	protein found in more fusions	6	0.800	1.179	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GTPase_binding (PF09027, IPR015116): GTPase binding Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
104	TRAF2	interactor	10	0.306	31.136	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
105	TRAF6	protein found in more fusions	9	0.286	28.914	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
106	TRPV4	interactor	2	1.000	0	Ion_trans (PF00520, IPR005821): Ion transport protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
107	TSR1	interactor	2	1.000	0	AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
108	USO1	interactor	9	0.429	69.020	Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain MutS_III (PF05192, IPR007696, SM00533): MutS domain III ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
109	VAPA	interactor	10	0.356	68.101	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) UL45 (PF05473, IPR008646): UL45 protein, carbohydrate-binding C-type lectin-like Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
110	YKT6	interactor	10	0.533	33.175	Synaptobrevin (PF00957, IPR001388): Synaptobrevin Longin (PF13774, IPR010908): Regulated-SNARE-like domain
111	ZBTB8A	interactor	4	0.667	0.500	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
112	ZNF512B	interactor	1	0	0	YTV (PF07639, IPR011521): YTV zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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