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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)121
The number (and %) of the onco-proteins37 (30.58 %)
The number (and %) of the tumor suppressors17 (14.05 %)
Total number of binary PPIs (saturation %)486 (6.69 %)
The number (and %) of affected PPIs124 (25.51 %)
The number of possible different fusions23
PPI diameter4
PPI radius2
The average degree of PPI7.289
Assortativity coefficient-0.2574
The network average Clustering coefficient0.369
The number (and %) of a zero Clustering coefficients25 (20.66 %)
The number (and %) of a zero Betweenness Centrality27 (22.31 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: LIMK1,YES1 All fusions
Proteins found in more fusions TRAF6 (see 1 fusions); CDH1 (see 3 fusions); APP (see 4 fusions); KHDRBS1 (see 1 fusions); MAPRE1 (see 1 fusions); ERBIN (see 4 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); BRAF (see 3 fusions); EPHB2 (see 1 fusions); CUL7 (see 2 fusions); PTK2 (see 2 fusions); SNAP23 (see 1 fusions); SLC9A3R1 (see 2 fusions); FYN (see 1 fusions); PAK4 (see 1 fusions); MAPK14 (see 1 fusions); LIMK1 (see 1 fusions); NEDD4 (see 1 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 LIMK1parental protein390.0702844.458LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 YES1parental protein850.0527453.283Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
YdjC (PF04794, IPR006879): YdjC-like protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
3 ACSL3oncoprotein40.5009.661AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
4 ADAM15interactor21.0000CD20 (PF04103, IPR007237): CD20-like family
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
5 ANKRD12oncoprotein30.33394.267CDK5_activator (PF03261, IPR004944): Cyclin-dependent kinase 5 activator protein
GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family
DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
UPF0767 (PF15990, IPR031933): UPF0767 family
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
6 ANLNoncoprotein90.52858.567Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
7 APPprotein found in more fusions310.110914.094APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 ARRB1interactor160.333228.249Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
9 ARRB2interactor160.225204.015Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10 ATP6V1E1interactor205.378vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
11 BADoncoprotein40.8330.750Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
12 BECN1suppressor60.40010.131APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
13 BLMHinteractor50.33317.831Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
14 BMPR2suppressor3034.227Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
15 BRAFoncoprotein50.6675.524Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
16 C1orf94interactor200DUF4688 (PF15752, IPR031496): Domain of unknown function (DUF4688)
17 CBLsuppressor140.231146.684Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
18 CCNL2interactor30.33332.372Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
19 CCR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
20 CD36interactor30.3336.399CD36 (PF01130, IPR002159): CD36 family
21 CD46oncoprotein100Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
DUF3188 (PF11384, IPR021524): Protein of unknown function (DUF3188)
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
22 CDH1suppressor70.6672.500Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
23 CDKN1Csuppressor100CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family
TonB_N (PF16031): TonB N-terminal region
24 CFL1interactor150.343131.367Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
25 CSF1Roncoprotein60.5334.094ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
26 CTNND1suppressor90.33361.325Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
27 CUL7protein found in more fusions140.218134.874ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
28 CYP51A1interactor30.6671.858p450 (PF00067, IPR001128): Cytochrome P450
29 DBN1oncoprotein130.44964.545Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
30 DOK1suppressor50.6673.542IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
31 DVL2interactor80.33325.249DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
32 DYNLT1interactor40.33316.515Tctex-1 (PF03645, IPR005334): Tctex-1 family
33 EGFRoncoprotein290.188572.240Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
34 ELAVL1oncoprotein260.130841.882RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
35 EPHB2suppressor31.0000EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
36 ERBINoncoprotein70.13349.655LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
37 FAF2interactor40.6670.417DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
UBX (PF00789, IPR001012, SM00166): UBX domain
Thioredoxin_7 (PF13899): Thioredoxin-like
UBA_4 (PF14555): UBA-like domain
38 FASLGinteractor40.33398.379PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
39 FLOT1interactor90.38935.079CrtC (PF07143, IPR010791): CrtC N-terminal lipocalin domain
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
40 FN1oncoprotein170.243243.541fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
41 FUNDC1interactor100FUN14 (PF04930, IPR007014): FUN14 family
42 FXR2interactor70.4008.371Agenet (PF05641, IPR008395, SM00743): Agenet domain
REV (PF00424, IPR000625): REV protein (anti-repression trans-activator protein)
KH_1 (PF00013, IPR004088, SM00322): KH domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
43 FYNoncoprotein300.096917.096Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
44 FYTTD1interactor3064.691FYTT (PF07078, IPR009782): Forty-two-three protein
45 GPR35interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
46 GRPEL2interactor21.0000GrpE (PF01025, IPR000740): GrpE
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
47 HIST1H1Ainteractor50.30045.532Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
48 HNRNPH1oncoprotein100.44436.241RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
49 HOXB5interactor21.0000DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
50 HSP90AA1oncoprotein230.234527.140HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
51 HSPA4interactor80.39336.225Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
52 ILF2interactor60.6673.055DZF (PF07528, IPR006561, SM00572): DZF domain
53 ITGA1interactor100FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat
LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
54 JSRP1interactor2026.967SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
JSRP (PF15312, IPR026178): Junctional sarcoplasmic reticulum protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
55 KHDRBS1protein found in more fusions60.4004.213KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
56 KIToncoprotein30.6670.917ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
57 LAMTOR1interactor21.0000LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
58 LATS1suppressor50.30022.651Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
59 LIMA1suppressor150.42959.111LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
60 LIMCH1interactor60.53312.188LIM (PF00412, IPR001781, SM00132): LIM domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
DUF3435 (PF11917, IPR021842): Protein of unknown function (DUF3435)
DUF4757 (PF15949, IPR031865): Domain of unknown function (DUF4757)
61 LIMK2interactor60.33335.269LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
62 MAPK14oncoprotein100.19497.293Pkinase (PF00069, IPR000719): Protein kinase domain
63 MAPKAPK2oncoprotein50.5003.189Pkinase (PF00069, IPR000719): Protein kinase domain
64 MAPRE1oncoprotein100.30680.179CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
65 MBPinteractor30.6671.389Myelin_MBP (PF01669, IPR000548): Myelin basic protein
66 MED28interactor50.50045.657cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
67 MIIPinteractor100Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
MIIP (PF15734, IPR031466): Migration and invasion-inhibitory
68 MYConcoprotein120.236158.581HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
69 MYH9suppressor170.368103.386IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
70 NEDD4suppressor120.27371.222Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
71 NFKBIAoncoprotein60.40031.068Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
72 NIF3L1interactor41.0000NIF3 (PF01784, IPR002678): NIF3 (NGG1p interacting factor 3)
73 NPHS1interactor31.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
DUF4643 (PF15485, IPR028004): Domain of unknown function (DUF4643)
74 NRG1interactor202.648EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
75 NSUN2interactor40.5009.976Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
76 OCLNinteractor21.0000MARVEL (PF01284, IPR008253): Membrane-associating domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
77 OGTinteractor40.5002.500TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41
TPR_19 (PF14559): Tetratricopeptide repeat
78 OLIG1interactor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
79 OSBPL5interactor21.0000Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
80 PAK1oncoprotein80.47651.954PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
81 PAK4protein found in more fusions70.40043.888PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
82 PAN2interactor110.41830.720RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
83 PARK2suppressor120.41866.534IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
84 PDCD6IPinteractor60.7002.341BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
85 PDLIM7interactor60.4006.561LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
86 PECAM1oncoprotein31.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
87 PIFOinteractor100SHIPPO-rpt (PF07004, IPR010736): Sperm-tail PG-rich repeat
88 POLR2Dinteractor30.66712.275RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
89 PPP1CBinteractor130.37273.405Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
90 PTENsuppressor120.25877.881DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
91 PTK2protein found in more fusions130.40951.864FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
92 RAD54Linteractor100Rad54_N (PF08658, IPR013967): Rad54 N terminal
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
93 RASA1oncoprotein90.33368.448C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
94 RPL10suppressor80.32120.673Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
95 RRASoncoprotein5092.091Ras (PF00071, IPR001806, SM00173): Ras family
96 RTEL1oncoprotein100C1_2 (PF03107, IPR004146): C1 domain
DEAD_2 (PF06733, IPR010614): DEAD_2
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
DZR (PF12773, IPR025874): Double zinc ribbon
Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain
CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
97 SARNPoncoprotein204.560SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
98 SH3PXD2Binteractor2016.352PX (PF00787, IPR001683, SM00312): PX domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
99 SLC16A14interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
100 SLC25A11interactor50.5001.987Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
101 SLC25A41interactor40.16759.225Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
102 SLC30A4interactor100Cation_efflux (PF01545, IPR002524): Cation efflux family
103 SLC9A3R1suppressor40.33310.041EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
104 SNAP23protein found in more fusions70.46717.115DivIC (PF04977, IPR007060): Septum formation initiator
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SNAP-25 (PF00835, IPR000928): SNAP-25 family
DUF5089 (PF17002, IPR031547): Domain of unknown function (DUF5089)
105 SOCS3suppressor90.41727.448SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
106 SPRR2Ainteractor100SPRR2 (PF14820, IPR029142): Small proline-rich 2
107 SRPK1interactor80.35748.908FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
108 SSBP3oncoprotein205.378SSDP (PF04503): Single-stranded DNA binding protein, SSDP
109 TADA3interactor2019.233GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
110 THAP1interactor60.30029.277THAP (PF05485, IPR006612, SM00980): THAP domain
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
111 TMEM17interactor80.214101.299Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
112 TMEM185Ainteractor30.33332.372Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
113 TNK2interactor60.8000.878CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
114 TRAF2interactor110.28965.736MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
115 TRAF6protein found in more fusions110.22258.112SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
116 TRPV4interactor30.3337.199Ion_trans (PF00520, IPR005821): Ion transport protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
117 TSR1interactor30.33387.414AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
118 UXTinteractor21.0000Prefoldin (PF02996, IPR004127): Prefoldin subunit
119 YWHAZprotein found in more fusions160.210238.62614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
120 ZBTB8Ainteractor40.6670.500BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
121 ZNF512Binteractor100YTV (PF07639, IPR011521): YTV
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
zf-Nse (PF11789, IPR004181): Zinc-finger of the MIZ type in Nse subunit
Zn_Tnp_IS1595 (PF12760, IPR024442): Transposase zinc-ribbon domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_aberr (PF17017, IPR031514): Aberrant zinc-finger

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