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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)117
The number (and %) of the onco-proteins27 (23.08 %)
The number (and %) of the tumor suppressors13 (11.11 %)
Total number of binary PPIs (saturation %)530 (7.81 %)
The number (and %) of affected PPIs115 (21.70 %)
The number of possible different fusions17
PPI diameter5
PPI radius3
The average degree of PPI8.393
Assortativity coefficient-0.1938
The network average Clustering coefficient0.461
The number (and %) of a zero Clustering coefficients6 (5.13 %)
The number (and %) of a zero Betweenness Centrality14 (11.97 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: WARS,SNX6 All fusions
Proteins found in more fusions APP (see 4 fusions); TSN (see 1 fusions); TRIM25 (see 2 fusions); CTPS2 (see 1 fusions); U2AF2 (see 2 fusions); APEH (see 1 fusions); ATP6V1C1 (see 3 fusions); IMPDH2 (see 2 fusions); NDEL1 (see 1 fusions); NT5C2 (see 5 fusions); MDH2 (see 1 fusions); EGFR (see 2 fusions); SNX1 (see 1 fusions); PCNA (see 1 fusions); VPS35 (see 2 fusions); STAT1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 WARSparental protein600.0883749.306tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
2 SNX6parental protein550.0863221.791PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
3 AARSinteractor60.46716.993DHHA1 (PF02272, IPR003156): DHHA1 domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
tRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
4 ACSS2interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
ACAS_N (PF16177, IPR032387): Acetyl-coenzyme A synthetase N-terminus
5 ACVR2Binteractor40.6671.619Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
6 ACVRL1interactor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
7 ADSLinteractor100.42223.332DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
8 ANP32Einteractor60.73310.845BUD22 (PF09073, IPR015158): BUD22
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
9 APEHoncoprotein70.80017.170Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
10 APPprotein found in more fusions240.095876.489APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
11 ATG7interactor110.56459.330ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
12 ATP6V1C1protein found in more fusions150.53849.281V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
13 BMPR1Binteractor304.159Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
14 BRCA1suppressor120.109217.914BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
15 BRMS1suppressor304.159Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family
Sds3 (PF08598, IPR013907): Sds3-like
16 C14orf166interactor70.38164.277RLL (PF10036, IPR019265): Putative carnitine deficiency-associated protein
17 CALM1interactor80.25074.186EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 CALUinteractor70.47627.329EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
19 CAMKMTinteractor50.30035.426Methyltransf_16 (PF10294, IPR019410): Lysine methyltransferase
20 CCDC22interactor90.250116.747DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
21 CCNL2interactor40.33317.814Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
22 CCT3interactor80.32155.313Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
23 CD81interactor40.3337.969Tetraspannin (PF00335, IPR018499): Tetraspanin family
24 CDAoncoprotein21.0000dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
dCMP_cyt_deam_2 (PF08211, IPR013171): Cytidine and deoxycytidylate deaminase zinc-binding region
25 CDC34oncoprotein70.46737.381UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
26 CEP41interactor30.6670.667Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
27 COILinteractor60.60013.126CDC45 (PF02724, IPR003874): CDC45-like protein
Macoilin (PF09726, IPR019130): Transmembrane protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
28 CSNK2A2interactor70.23867.214Pkinase (PF00069, IPR000719): Protein kinase domain
29 CTPS2protein found in more fusions80.61916.486CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
30 CTSDinteractor21.0000A1_Propeptide (PF07966, IPR012848): A1 Propeptide
Asp (PF00026, IPR001461): Eukaryotic aspartyl protease
31 DCAF13interactor30.33310.779eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
Sof1 (PF04158, IPR007287): Sof1-like domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
32 DDA1interactor40.16718.334DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
33 DISC1interactor50.20080.447HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
34 DNM3interactor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
35 DNMT3Bsuppressor206.969DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
36 EGFRoncoprotein170.242321.084Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37 EHD1interactor110.44496.271Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
38 EHD4interactor100.37895.104GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
39 ELAVL1oncoprotein170.117450.129RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
40 ESR1suppressor90.28693.881Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
41 FAM129Binteractor100.55671.102PH (PF00169, IPR001849, SM00233): PH domain
42 FAM221Ainteractor21.0000FAM221 (PF14753, IPR026755): Protein FAM221A/B
43 FAM43Ainteractor100PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
44 FBXW11interactor100.25067.563WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
45 FKBP9interactor70.47632.342FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
46 GARTinteractor90.44462.880AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
Formyl_trans_N (PF00551, IPR002376): Formyl transferase
GARS_A (PF01071, IPR020561): Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
GARS_C (PF02843, IPR020560): Phosphoribosylglycinamide synthetase, C domain
GARS_N (PF02844, IPR020562): Phosphoribosylglycinamide synthetase, N domain
47 GATSinteractor21.0000ACT_7 (PF13840, IPR027795): ACT domain
48 GBASinteractor31.0000NIPSNAP (PF07978, IPR012577): NIPSNAP
49 GIT1interactor50.33324.076ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GIT_SHD (PF08518, IPR013724, SM00555): Spa2 homology domain (SHD) of GIT
GIT1_C (PF12205, IPR022018): G protein-coupled receptor kinase-interacting protein 1 C term
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
FlxA (PF14282, IPR025577): FlxA-like protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
50 GNPDA1interactor70.6675.898Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
51 GTF2A1oncoprotein60.60010.776TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
52 GTF2Iinteractor110.255120.997GTF2I (PF02946, IPR004212): GTF2I-like repeat
53 GTF3C4interactor80.50032.376TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
54 H3F3Aoncoprotein80.6078.197Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
55 HARSinteractor60.333126.990HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
56 HERC2interactor70.13375.503ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
57 HERC4interactor90.57140.867RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
58 HIP1Rinteractor80.50051.322ANTH (PF07651, IPR011417): ANTH domain
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
59 HSD17B12interactor30.6675.493adh_short (PF00106, IPR002198): short chain dehydrogenase
60 IFI16suppressor100.156156.468HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
61 IMPDH2protein found in more fusions70.40042.276IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
62 INSRinteractor50.70016.615fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
63 ISG15suppressor60.26734.324ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
64 KPNA2interactor70.38125.311Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
65 KTN1oncoprotein50.60025.096ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
66 LEPRoncoprotein40.8330.622fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
67 LIG4interactor21.0000APG17 (PF04108, IPR007240): Autophagy protein Apg17
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
68 MDH2protein found in more fusions60.8001.884Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
69 MVB12Ainteractor60.46737.486DUF2464 (PF10240, IPR018798): Protein of unknown function (DUF2464)
70 NDEL1protein found in more fusions40.3338.610HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
71 NT5C2protein found in more fusions100.47253.5805_nucleotid (PF05761, IPR008380): 5' nucleotidase family
72 NTRK1oncoprotein500.1052687.965I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
73 NUCB1interactor40.6671.673DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
74 PAWRsuppressor100.6899.316ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
75 PCID2interactor60.5335.791PCI (PF01399, IPR000717, SM00088): PCI domain
76 PCNAoncoprotein140.321109.540PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
77 PDGFRAoncoprotein90.53647.427Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
LAT (PF15234, IPR008359): Linker for activation of T-cells
78 PFASinteractor100.33392.335AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
79 PHLPP1suppressor30.6675.259LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
80 PIM1oncoprotein70.26780.377Pkinase (PF00069, IPR000719): Protein kinase domain
81 PSMA3interactor80.47627.402Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
82 PSMG1interactor70.40025.730PAC1 (PF16094, IPR016565): Proteasome assembly chaperone 4
83 PSMG2interactor40.6672.626PAC2 (PF09754, IPR019151): PAC2 family
84 RABIFinteractor21.0000Mss4 (PF04421, IPR007515): Mss4 protein
DNA_RNApol_7kD (PF03604, IPR006591, SM00659): DNA directed RNA polymerase, 7 kDa subunit
85 RAD23Aoncoprotein110.48916.478UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
86 RTF1interactor60.133161.809K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Plus-3 (PF03126, IPR004343): Plus-3 domain
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
YL1 (PF05764, IPR008895): YL1 nuclear protein
AAA_23 (PF13476): AAA domain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
87 SARSinteractor120.303239.691NOD (PF06816, IPR010660): NOTCH protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
88 SH3GLB1suppressor50.5008.117BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
89 SHMT1interactor130.50060.598SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
90 SHMT2interactor200.247395.782SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
91 SIRT7interactor160.150226.255DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
92 SMCHD1suppressor70.38141.418Big_1 (PF02369, IPR003344, SM00634): Bacterial Ig-like domain (group 1)
SMC_hinge (PF06470, IPR010935, SM00968): SMC proteins Flexible Hinge Domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
93 SNX1protein found in more fusions180.353280.287PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
94 SNX2interactor280.225695.758PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
95 SNX4interactor60.6674.221PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
96 STAT1suppressor220.281393.521SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
97 TATDN1interactor40.8330.500TatD_DNase (PF01026, IPR001130): TatD related DNase
98 TEAD4interactor100TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
99 TERF1interactor80.19042.576TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
100 TGFBR1oncoprotein40.50013.435Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
101 TGFBR2suppressor60.20062.642ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
102 TMOD1interactor30.66718.586Tropomodulin (PF03250, IPR004934): Tropomodulin
103 TNIKinteractor30.33317.151CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499)
CNDH2_M (PF16869): PF16858
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
104 TREML2interactor21.0000Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
105 TRIM25protein found in more fusions110.24493.422Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1
Pox_Rif (PF03340, IPR005008): Poxvirus rifampicin resistance protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
106 TSG101suppressor100.47263.446APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
107 TSNprotein found in more fusions80.7145.168Translin (PF01997, IPR002848): Translin family
108 TSNAXinteractor30.6671.282Translin (PF01997, IPR002848): Translin family
109 TWF1interactor60.66710.229Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
110 U2AF2protein found in more fusions140.231159.287RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
111 USP46interactor30.6671.000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
112 USP5interactor120.43978.098UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
113 VAPBinteractor30.6674.101ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
ZapB (PF06005, IPR009252): Cell division protein ZapB
Motile_Sperm (PF00635, IPR000535): MSP (Major sperm protein) domain
114 VPS29interactor130.513136.152Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
115 VPS35protein found in more fusions140.44997.898FerA (PF08165, IPR012560): FerA (NUC095) domain
Vps35 (PF03635, IPR005378): Vacuolar protein sorting-associated protein 35
116 VPS37Binteractor31.0000Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
117 XPNPEP1interactor110.345109.679Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

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