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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)94
The number (and %) of the onco-proteins20 (21.28 %)
The number (and %) of the tumor suppressors7 (7.45 %)
Total number of binary PPIs (saturation %)1320 (30.20 %)
The number (and %) of affected PPIs97 (7.35 %)
The number of possible different fusions17
PPI diameter4
PPI radius2
The average degree of PPI27.596
Assortativity coefficient0.2224
The network average Clustering coefficient0.635
The number (and %) of a zero Clustering coefficients3 (3.19 %)
The number (and %) of a zero Betweenness Centrality3 (3.19 %)


List of the fusions

PPI for parental proteins: FAU,MRPL49 All fusions
Proteins found in more fusions NPM1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); OXA1L (see 1 fusions); COPS5 (see 1 fusions); TP53 (see 3 fusions); PTBP1 (see 1 fusions); APP (see 5 fusions); RPS24/RPS23 (see 1 fusions); G3BP1 (see 1 fusions); RPS24/RPS27 (see 1 fusions); RPL5 (see 1 fusions); SERBP1 (see 1 fusions); TCF3 (see 4 fusions); MCM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 FAUparental protein570.540466.927Ribosomal_S30 (PF04758, IPR006846): Ribosomal protein S30
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
2 MRPL49parental protein400.231876.958Img2 (PF05046, IPR007740): Mitochondrial large subunit ribosomal protein (Img2)
3 AHSA1interactor190.8483.459Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
4 APPprotein found in more fusions290.402108.440APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 BTRConcoprotein150.38528.862WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 BYSLinteractor120.7581.963Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
7 CAND1interactor490.608192.481Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
8 CD81interactor260.85324.401Tetraspannin (PF00335, IPR018499): Tetraspanin family
9 CDH2interactor80.6075.055Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
10 CEP57interactor130.61513.306Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family
11 COPS5protein found in more fusions460.597221.324JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
12 COPS6interactor130.8334.743DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
13 CUL1suppressor450.642139.498Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
14 CUL3protein found in more fusions500.501305.051Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15 DLSToncoprotein30.6670.7022-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
16 DYNLL1interactor80.6199.570Dynein_light (PF01221, IPR001372): Dynein light chain type 1
17 FBXW11interactor120.43610.446WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
18 FN1oncoprotein380.79934.952fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
19 G3BP1protein found in more fusions150.51613.786NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
20 GRB2oncoprotein90.8570.615SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
21 HDLBPoncoprotein30.6670.420BMC (PF00936, IPR000249, SM00877): BMC domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
KH_5 (PF13184, IPR025249): NusA-like KH domain
SLS (PF14611, IPR032741): Mitochondrial inner-membrane-bound regulator
DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
22 ICAM1oncoprotein230.9840.253Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
23 IGSF8oncoprotein240.9820.340V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
24 IL7Rinteractor70.6671.273fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
25 KRASoncoprotein90.39311.849Ras (PF00071, IPR001806, SM00173): Ras family
26 MCM2oncoprotein450.535428.808AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
27 METTL18interactor100Methyltransf_23 (PF13489): Methyltransferase domain
28 MGST3interactor21.0000MAPEG (PF01124, IPR001129): MAPEG family
29 MOV10interactor220.390117.086AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
30 MRPL1interactor190.63223.570CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
31 MRPL28interactor170.69921.342Ribosomal_L28 (PF00830, IPR001383): Ribosomal L28 family
32 MRPL37interactor190.52641.684PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
33 MRPL38interactor180.62123.285PBP (PF01161, IPR008914): Phosphatidylethanolamine-binding protein
DUF3095 (PF11294, IPR021445): Protein of unknown function (DUF3095)
34 MRPL39interactor190.55670.901TGS (PF02824, IPR004095): TGS domain
DUF2469 (PF10611, IPR019592): Protein of unknown function (DUF2469)
35 MRPL4interactor180.58224.746Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
36 MRPL47interactor150.7437.337MRP-L47 (PF06984, IPR010729): Mitochondrial 39-S ribosomal protein L47 (MRP-L47)
37 MRPL50interactor180.65428.928Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
38 MRPL52interactor150.60017.677SDP_N (PF12278, IPR022063): Sex determination protein N terminal
39 MRPL58interactor220.44684.231RF-1 (PF00472, IPR000352): RF-1 domain
40 MRPL9interactor180.58837.330Ribosomal_L9_N (PF01281, IPR020070): Ribosomal protein L9, N-terminal domain
41 MRPS30interactor150.8293.646PDCD9 (PF07147, IPR010793): Mitochondrial 28S ribosomal protein S30 (PDCD9)
42 MTHFD1interactor80.35712.627FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
43 NANOGinteractor50.6671.266Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
44 NENFinteractor90.47213.820Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
45 NPM1suppressor610.472473.983Nucleoplasmin (PF03066): Nucleoplasmin/nucleophosmin domain
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
46 NXF1interactor160.41953.673NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
47 OXA1Lprotein found in more fusions70.6001.79260KD_IMP (PF02096, IPR001708): 60Kd inner membrane protein
48 PA2G4interactor120.6364.958Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
49 PNO1interactor190.8892.699KH_1 (PF00013, IPR004088, SM00322): KH domain
50 PPT2interactor80.46410.609Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Palm_thioest (PF02089, IPR002472): Palmitoyl protein thioesterase
51 PRKCDBPsuppressor70.4767.191A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
52 PTBP1oncoprotein190.49055.499RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
53 PYM1interactor290.75423.608CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Mago-bind (PF09282, IPR015362): Mago binding
AAA_23 (PF13476): AAA domain
54 RPL11suppressor460.74546.718Ribosomal_L5 (PF00281, IPR002132): Ribosomal protein L5
Ribosomal_L5_C (PF00673, IPR002132): ribosomal L5P family C-terminus
55 RPL12interactor430.77339.979Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
56 RPL13interactor520.576275.411Ribosomal_L13e (PF01294, IPR001380): Ribosomal protein L13e
57 RPL18interactor440.78849.685Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
58 RPL23Ainteractor440.79853.927Ribosomal_L23 (PF00276, IPR013025): Ribosomal protein L23
Ribosomal_L23eN (PF03939, IPR005633): Ribosomal protein L23, N-terminal domain
59 RPL27Ainteractor370.8927.326Ribosomal_L27A (PF00828, IPR021131): Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A
60 RPL5suppressor440.83126.101Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
61 RPS12interactor390.85013.093Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
62 RPS13interactor490.73475.459Ribosomal_S13_N (PF08069, IPR012606): Ribosomal S13/S15 N-terminal domain
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
63 RPS15interactor400.80926.428Ribosomal_S19 (PF00203, IPR002222): Ribosomal protein S19
Prok_Ub (PF14454, IPR032866): Prokaryotic Ubiquitin
64 RPS15Ainteractor450.75840.814Ribosomal_S8 (PF00410, IPR000630): Ribosomal protein S8
65 RPS16interactor510.676192.592Ribosomal_S9 (PF00380, IPR000754): Ribosomal protein S9/S16
66 RPS17interactor340.8739.534Ribosomal_S17e (PF00833, IPR001210): Ribosomal S17
67 RPS18interactor500.666127.817Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
68 RPS19interactor480.73779.386Ribosomal_S19e (PF01090, IPR001266): Ribosomal protein S19e
69 RPS2interactor520.631258.499Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain
Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
70 RPS20interactor480.69493.985Ribosomal_S10 (PF00338, IPR027486): Ribosomal protein S10p/S20e
71 RPS23protein found in more fusions470.75735.840Ribosom_S12_S23 (PF00164, IPR006032): Ribosomal protein S12/S23
72 RPS24protein found in more fusions430.77640.138Fascin (PF06268, IPR022768): Fascin domain
Ribosomal_S24e (PF01282, IPR001976): Ribosomal protein S24e
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
73 RPS25interactor490.74538.622Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
74 RPS26interactor450.641189.997Ribosomal_S26e (PF01283, IPR000892): Ribosomal protein S26e
75 RPS27protein found in more fusions430.80827.077Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
76 RPS27Linteractor300.84614.429E7 (PF00527, IPR000148): E7 protein, Early protein
Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
77 RPS28interactor430.80631.376Ribosomal_S28e (PF01200, IPR000289): Ribosomal protein S28e
78 RPS29interactor290.84523.690Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
79 RPS3interactor540.639143.888KH_2 (PF07650, IPR004044): KH domain
Ribosomal_S3_C (PF00189, IPR001351): Ribosomal protein S3, C-terminal domain
80 RPS4Xinteractor490.73151.128KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_S4e (PF00900, IPR013845): Ribosomal family S4e
RS4NT (PF08071, IPR013843): RS4NT (NUC023) domain
S4 (PF01479, IPR002942, SM00363): S4 domain
40S_S4_C (PF16121, IPR032277): 40S ribosomal protein S4 C-terminus
81 RPS6interactor460.79122.997Ribosomal_S6e (PF01092, IPR001377): Ribosomal protein S6e
DUF4574 (PF15141, IPR027896): Domain of unknown function (DUF4574)
82 RPS7interactor450.77233.573Ribosomal_S7e (PF01251, IPR000554): Ribosomal protein S7e
83 RPS8interactor540.588280.277Ribosomal_S8e (PF01201, IPR022309): Ribosomal protein S8e
84 RPS9interactor460.79225.273Ribosomal_S4 (PF00163, IPR001912): Ribosomal protein S4/S9 N-terminal domain
S4 (PF01479, IPR002942, SM00363): S4 domain
85 RPSAinteractor450.721102.231Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
86 SCFD1interactor60.33314.863Sec1 (PF00995, IPR001619): Sec1 family
87 SERBP1protein found in more fusions230.61918.762HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
88 SPTAN1oncoprotein100.35625.129EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
89 TAF7interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ELM2 (PF01448, IPR000949): ELM2 domain
TAFII55_N (PF04658, IPR006751): TAFII55 protein conserved region
XhlA (PF10779, IPR019715): Haemolysin XhlA
Noelin-1 (PF12308, IPR022082): Neurogenesis glycoprotein
90 TCF3suppressor70.4003.994CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
91 TIMM10interactor200.551zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
92 TMEM177interactor80.50010.490NA
93 TP53suppressor340.65368.134DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
94 TSR1interactor360.600185.817AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain
RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein

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