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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins UBE2G2, C1orf61 (from a repository: Fri Nov 9 08:46:22 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins18 (33.96 %)
The number (and %) of the tumor suppressors3 (5.66 %)
Total number of binary PPIs (saturation %)128 (9.29 %)
The number (and %) of affected PPIs52 (40.62 %)
The number of possible different fusions11
PPI diameter2
PPI radiusinf
The average degree of PPI4.000
Assortativity coefficient-0.3885
The network average Clustering coefficient0.413
The number (and %) of a zero Clustering coefficients21 (39.62 %)
The number (and %) of a zero Betweenness Centrality31 (58.49 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: C1orf61,UBE2G2 All fusions
Proteins found in more fusions HNRNPD (see 1 fusions); RFFL (see 1 fusions); MALT1 (see 1 fusions); RNF111 (see 1 fusions); UBC (see 1 fusions); BAG3 (see 4 fusions); SHFM1/BAG3 (see 1 fusions); RNF168 (see 2 fusions); EGFR (see 2 fusions); UBA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 C1orf61interactor000NA
2 UBE2G2parental protein520.0432231.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 AMFRoncoprotein70.6005.333CUE (PF02845, IPR003892, SM00546): CUE domain
UbiA (PF01040, IPR000537): UbiA prenyltransferase family
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
4 ARL14interactor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
5 AUP1interactor70.42911.167CUE (PF02845, IPR003892, SM00546): CUE domain
6 BAG3oncoprotein50.6671.667BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 BIRC8interactor100BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 CNNM3interactor100CBS (PF00571, IPR000644, SM00116): CBS domain
DUF21 (PF01595, IPR002550): Domain of unknown function DUF21
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
9 CORO1Aoncoprotein100DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
10 CPOXinteractor100Coprogen_oxidas (PF01218, IPR001260): Coproporphyrinogen III oxidase
11 EGFRoncoprotein50.6671.167Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 ERLEC1interactor100PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
13 FARP2interactor100FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
14 FBXW11interactor110.31128.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
15 HBS1Linteractor100HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
16 HNRNPABinteractor40.6671.667CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
17 HNRNPDoncoprotein80.4769.000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 HNRNPDLinteractor40.8330.667CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 KDM2Ainteractor21.0000JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
DZR (PF12773, IPR025874): Double zinc ribbon
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PHD_4 (PF16866, IPR019787): PHD-finger
20 KIAA0368interactor60.3338.667HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
CLASP_N (PF12348, IPR024395): CLASP N terminal
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
Ecm29 (PF13001, IPR024372): Proteasome stabiliser
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
21 MALT1oncoprotein200Peptidase_C14 (PF00656, IPR011600): Caspase domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
22 MDM2oncoprotein70.4676.167Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
23 MGRN1interactor21.0000zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
24 MLLT6oncoprotein100DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
25 MUL1interactor40.6670.667DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
26 NDUFS4interactor21.0000ETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
27 OTUB1interactor50.6003.167Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
28 PARK2suppressor70.4677.333IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
29 POLR3Finteractor100RNA_pol_Rpc34 (PF05158, IPR007832): RNA polymerase Rpc34 subunit
30 RBX1oncoprotein31.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
31 RC3H1interactor100PaaA_PaaC (PF05138, IPR007814): Phenylacetic acid catabolic protein
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
32 RC3H2interactor31.0000Xin (PF08043, IPR012510): Xin repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
33 RFFLprotein found in more fusions40.6670.667FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Armet (PF10208, IPR019345): Degradation arginine-rich protein for mis-folding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34 RNF111suppressor31.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
35 RNF139oncoprotein21.0000zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
36 RNF146interactor200WWE (PF02825, IPR004170, SM00678): WWE domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
37 RNF157oncoprotein100Peptidase_C70 (PF12385, IPR022118): Papain-like cysteine protease AvrRpt2
TBX (PF12598, IPR022582): T-box transcription factor
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
38 RNF168protein found in more fusions40.6670.500ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
39 RNF26interactor100GtrA (PF04138, IPR007267): GtrA-like protein
Herpes_UL37_1 (PF03970, IPR005655): Herpesvirus UL37 tegument protein
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
40 RNF5interactor41.0000zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
41 SHFM1protein found in more fusions60.4676.667CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
42 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
43 TMEM45Binteractor100DUF716 (PF04819, IPR006904): Family of unknown function (DUF716)
DUF4133 (PF13571, IPR025407): Domain of unknown function (DUF4133)
44 TRIM3suppressor200C1_2 (PF03107, IPR004146): C1 domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
NHL (PF01436, IPR001258): NHL repeat
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
45 TRIM43interactor100PaaX_C (PF08223, IPR013225): PaaX-like protein C-terminal domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
46 TRIM9interactor50.6671.667fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Fer4_4 (PF12800, IPR001450): 4Fe-4S binding domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
47 UBA1protein found in more fusions50.6671.167ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
48 UBA6interactor21.0000ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
49 UBCprotein found in more fusions180.184104.667ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50 UBL4Ainteractor70.5247.833ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
51 USP15oncoprotein50.8330.500UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
52 VAMP8oncoprotein100Synaptobrevin (PF00957, IPR001388): Synaptobrevin
53 ZNRF4interactor100PA (PF02225, IPR003137): PA domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger

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