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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ZBTB20, TST (from a repository: Mon Apr 23 07:29:11 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins5 (18.52 %)
The number (and %) of the tumor suppressors4 (14.81 %)
Total number of binary PPIs (saturation %)68 (19.37 %)
The number (and %) of affected PPIs25 (36.76 %)
The number of possible different fusions3
PPI diameter5
PPI radius3
The average degree of PPI4.519
Assortativity coefficient-0.2904
The network average Clustering coefficient0.526
The number (and %) of a zero Clustering coefficients6 (22.22 %)
The number (and %) of a zero Betweenness Centrality11 (40.74 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ZBTB20,TST All fusions
Proteins found in more fusions HSP90AA1 (see 2 fusions); NR3C1 (see 8 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ZBTB20parental protein120.394203.967BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
GTPase_binding (PF09027, IPR015116): GTPase binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
2 TSTparental protein130.090325.633Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
3 AIFM1oncoprotein100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
4 ANLNoncoprotein70.7624.333Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
5 CHD7interactor100CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
Myb_DNA-bind_7 (PF15963): Myb DNA-binding like
6 ELAVL1oncoprotein50.333168.600RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
7 FLNAsuppressor80.78623.800CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
8 HPDLinteractor100Glyoxalase_3 (PF13468, IPR025870): Glyoxalase-like domain
Glyoxalase_4 (PF13669): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
9 HSP90AA1oncoprotein60.400143.867HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
10 IQGAP1interactor61.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
11 LIMA1suppressor70.9520.333LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
12 MRPL50interactor100Ribosomal_L50 (PF10501, IPR018305): Ribosomal subunit 39S
13 MYH9suppressor80.78623.800IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
14 MYO19interactor70.9520.333IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
15 ND1interactor100NA
16 NEDD8interactor40.333143.400ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
17 NR3C1protein found in more fusions60.40032.233GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
18 PPARGsuppressor31.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
19 PSMB2interactor21.0000Proteasome (PF00227, IPR001353): Proteasome subunit
20 PSMD7interactor21.0000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
Auts2 (PF15336): Autism susceptibility gene 2 protein
Coilin_N (PF15862, IPR031722): Coilin N-terminus
21 S100A16interactor21.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
22 SEC22Binteractor50.40080.267Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain
23 SEPT11interactor40.50068.533Septin (PF00735, IPR000038): Septin
DUF3080 (PF11279, IPR021431): Protein of unknown function (DUF3080)
24 SLC9A3R2interactor30.6670.667EBP50_C (PF09007, IPR015098): EBP50, C-terminal
GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
25 SNRPAinteractor200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 SYNPOinteractor70.9520.333Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
27 UBE2Minteractor50.5005.900UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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