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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins KCNQ1DN, TSSC1 (from a repository: Tue Aug 20 01:10:04 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins2 (7.69 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)54 (16.62 %)
The number (and %) of affected PPIs24 (44.44 %)
The number of possible different fusions2
PPI diameter2
PPI radiusinf
The average degree of PPI3.846
Assortativity coefficient-0.5407
The network average Clustering coefficient0.438
The number (and %) of a zero Clustering coefficients13 (50.00 %)
The number (and %) of a zero Betweenness Centrality22 (84.62 %)


List of the fusions

PPI for parental proteins: KCNQ1DN,TSSC1 All fusions
Proteins found in more fusions SNAP29 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 KCNQ1DNinteractor000NA
2 TSSC1parental protein240.094492.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
3 BBS1interactor100BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
4 CCT3interactor51.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
5 CCT6Ainteractor51.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
6 CCT6Binteractor51.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT7interactor51.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CWF19L1interactor100CwfJ_C_1 (PF04677, IPR006768): Protein similar to CwfJ C-terminus 1
CwfJ_C_2 (PF04676, IPR006767): Protein similar to CwfJ C-terminus 2
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
9 DDX11L8interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
10 DEGS1interactor100FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Lipid_DES (PF08557, IPR013866): Sphingolipid Delta4-desaturase (DES)
11 DTNBP1interactor41.0000Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
12 ETV3oncoprotein100Ets (PF00178, IPR000418, SM00413): Ets-domain
13 FDXRinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
14 LRIF1interactor200LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
15 MOB1Asuppressor100Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
16 RPL23interactor100Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
17 SMG8interactor100Smg8_Smg9 (PF10220, IPR019354): Smg8_Smg9
18 SNAP29protein found in more fusions51.0000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
19 TCP1interactor51.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
20 TLE4interactor100TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4662 (PF15578, IPR028970): Domain of unknown function (DUF4662)
21 VPS50interactor70.7622.500Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
22 VPS51interactor70.7622.500DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
Vps51 (PF08700): Vps51/Vps67
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Sec5 (PF15469): Exocyst complex component Sec5
23 VPS52interactor61.0000Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
24 VPS53suppressor80.7622.500Vps53_N (PF04100, IPR007234): Vps53-like, N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
VPS53_C (PF16854, IPR031745): Vacuolar protein sorting-associated protein 53 C-terminus
25 VPS54interactor51.0000Vps54 (PF07928, IPR012501): Vps54-like protein
Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
SBP_bac_6 (PF13343): Bacterial extracellular solute-binding protein
YqzH (PF14164, IPR025546): YqzH-like protein
26 YEATS2interactor100YEATS (PF03366, IPR005033): YEATS family

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