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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins MCM5, TSSC1 (from a repository: Wed Sep 4 19:12:57 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)253
The number (and %) of the onco-proteins67 (26.48 %)
The number (and %) of the tumor suppressors20 (7.91 %)
Total number of binary PPIs (saturation %)2453 (7.69 %)
The number (and %) of affected PPIs251 (10.23 %)
The number of possible different fusions45
PPI diameter5
PPI radius3
The average degree of PPI18.838
Assortativity coefficient-0.2805
The network average Clustering coefficient0.499
The number (and %) of a zero Clustering coefficients16 (6.32 %)
The number (and %) of a zero Betweenness Centrality32 (12.65 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: MCM5,TSSC1 All fusions
Proteins found in more fusions CEBPA (see 1 fusions); PRDX1 (see 1 fusions); HDAC5 (see 1 fusions); EP300 (see 1 fusions); DDX5 (see 1 fusions); STAT1 (see 1 fusions); APP (see 5 fusions); ORC2 (see 2 fusions); HSP90AA1 (see 6 fusions); SFPQ (see 6 fusions); PRMT5 (see 1 fusions); HSP90AA1/PSMA3 (see 1 fusions); HSP90AB1 (see 3 fusions); RBPMS (see 1 fusions); SNRNP200 (see 2 fusions); PRPF8 (see 3 fusions); BAG3 (see 4 fusions); DDX17 (see 4 fusions); ATP5A1 (see 1 fusions); DDB1 (see 4 fusions); MATR3 (see 4 fusions); NCL (see 4 fusions); GAPDH (see 5 fusions); RBMX (see 3 fusions); EEF1A1 (see 6 fusions); S100A8 (see 3 fusions); COPE (see 1 fusions); L3MBTL1 (see 1 fusions); SNAP29 (see 1 fusions); KRT19 (see 1 fusions); EEF1A1/THRAP3 (see 1 fusions); PYGB (see 1 fusions); UBC (see 7 fusions); HSP90AA1/TUBB (see 1 fusions); MCM7 (see 2 fusions); LMNA (see 4 fusions); CRY2 (see 3 fusions); ACTN1 (see 3 fusions); DSP (see 4 fusions); ENO1/CCT7 (see 1 fusions); SH3KBP1 (see 1 fusions); MCM2 (see 1 fusions); HNRNPC (see 1 fusions); VIM (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 MCM5parental protein2270.07825754.359MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
2 TSSC1parental protein240.0942507.666WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
3 ACTBL2interactor80.6072.505Actin (PF00022, IPR004000, SM00268): Actin
4 ACTN1protein found in more fusions150.38525.278CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
5 AIREinteractor210.26355.306PHD (PF00628, IPR019787, SM00249): PHD-finger
SAND (PF01342, IPR000770, SM00258): SAND domain
HSR (PF03172, IPR004865): HSR domain
zf-PHD-like (PF15446): PHD/FYVE-zinc-finger like domain
6 ANXA2interactor180.45827.400Annexin (PF00191, IPR018502, SM00335): Annexin
7 ANXA2P2interactor40.8330.125NA
8 API5interactor50.6001.720API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
9 APPprotein found in more fusions500.1311337.377APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10 ASF1Binteractor110.6734.619ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
11 ATP5A1protein found in more fusions230.46342.966ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
12 AZGP1suppressor21.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
13 BAG3oncoprotein230.195103.096BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
14 BBS1interactor3036.699BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1
BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
15 BCAS2interactor120.6365.789BCAS2 (PF05700, IPR008409): Breast carcinoma amplified sequence 2 (BCAS2)
ZapB (PF06005, IPR009252): Cell division protein ZapB
16 C1QTNF2interactor21.0000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
17 CALML5interactor31.0000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
18 CAP1interactor140.56413.568CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
19 CCDC8interactor560.228422.531Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
20 CCT3interactor240.344547.619Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
21 CCT6Ainteractor220.398413.621Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
22 CCT6Binteractor80.679112.901Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
23 CCT7protein found in more fusions200.374421.238Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
24 CD81interactor490.166397.185Tetraspannin (PF00335, IPR018499): Tetraspanin family
25 CDC5Linteractor640.239834.161OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
26 CDC7interactor120.7097.064Pkinase (PF00069, IPR000719): Protein kinase domain
27 CDKN2Asuppressor230.37553.367Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
28 CEBPAsuppressor60.5001.638Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
29 CFL1interactor230.46259.893Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
30 CFL2interactor90.7862.027Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
31 CIAO1interactor30.6671.050WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
32 COPEprotein found in more fusions80.381320.513Coatomer_E (PF04733, IPR006822): Coatomer epsilon subunit
TPR_19 (PF14559): Tetratricopeptide repeat
33 CRY2protein found in more fusions200.22852.959DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
34 CWF19L1interactor100CwfJ_C_1 (PF04677, IPR006768): Protein similar to CwfJ C-terminus 1
CwfJ_C_2 (PF04676, IPR006767): Protein similar to CwfJ C-terminus 2
Metallophos_3 (PF14582, IPR029461): Metallophosphoesterase, calcineurin superfamily
35 DBN1oncoprotein190.39256.786Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
36 DCDinteractor60.6671.067Dermcidin (PF15291, IPR028130): Dermcidin, antibiotic peptide
37 DDB1protein found in more fusions160.34328.260CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
38 DDX11L8interactor100DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
39 DDX17protein found in more fusions340.41396.675CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Ferritin (PF00210, IPR008331): Ferritin-like domain
GRP (PF07172, IPR010800): Glycine rich protein family
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
40 DDX21interactor220.47224.103CRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
41 DDX27interactor100.46714.439Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
42 DDX5oncoprotein340.47265.877DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
P68HR (PF08061, IPR012587): P68HR (NUC004) repeat
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
43 DEGS1interactor100FA_desaturase (PF00487, IPR005804): Fatty acid desaturase
Lipid_DES (PF08557, IPR013866): Sphingolipid Delta4-desaturase (DES)
44 DHX15interactor350.432103.847DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
45 DHX9oncoprotein320.51658.880DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
46 DSC1interactor60.9330.286Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
47 DSG1interactor70.8570.875Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
48 DSPsuppressor140.48711.781APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CLP_protease (PF00574, IPR023562): Clp protease
DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fez1 (PF06818): Fez1
FIVAR (PF07554, IPR011490): Uncharacterised Sugar-binding Domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Rho_Binding (PF08912, IPR015008): Rho Binding
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
SOGA (PF11365, IPR027881): Protein SOGA
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
49 DTNBP1interactor50.60020.887Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
50 EEF1A1suppressor370.386388.064GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
51 EEF1A1P5interactor31.0000NA
52 EEF1A2oncoprotein80.5002.584GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
53 ENO1oncoprotein240.43871.215Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
54 EP300oncoprotein350.201185.675Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
55 ERP44interactor31.0000Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
56 ETV3oncoprotein2027.058Ets (PF00178, IPR000418, SM00413): Ets-domain
57 FAM188Asuppressor30.6670.286DUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
58 FBLinteractor280.44782.308Fibrillarin (PF01269, IPR000692): Fibrillarin
59 FBXO6interactor540.178450.744FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
60 FDXRinteractor100Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
61 FKBP5interactor110.50914.794FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
NuDC (PF16273, IPR032572): Nuclear distribution C domain
62 FLNAsuppressor310.40095.258CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
63 FLNBoncoprotein150.44827.204CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
64 FLNCinteractor110.5097.556CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
65 FN1oncoprotein860.1661261.423fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
66 GAPDHoncoprotein310.49457.137Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
67 GINS4interactor40.6671.333Sld5 (PF05916, IPR021151): GINS complex protein
SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus
68 GSPT1oncoprotein21.0000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
69 H2AFJinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
70 H2AFVinteractor60.6672.319Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
71 H2AFXsuppressor340.283135.804Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
72 H2AFZinteractor70.6193.093Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
73 H2BFSinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
74 H3F3Aoncoprotein160.47516.116Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
75 H3F3Binteractor50.7000.163Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
76 H3F3Concoprotein21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
77 HDAC5protein found in more fusions510.235320.138Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
78 HIST1H1Concoprotein160.42526.185Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
79 HIST1H1Dinteractor100.3333.513Stm1_N (PF09598, IPR019084): Stm1
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
80 HIST1H1Einteractor120.45510.667Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
81 HIST1H2AAinteractor70.5711.915Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
82 HIST1H2ABinteractor100.6003.222Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
83 HIST1H2ACinteractor40.8330.133Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
84 HIST1H2ADinteractor80.5716.331Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
85 HIST1H2AGinteractor50.8000.546Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
86 HIST1H2AHinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
87 HIST1H2AJinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
88 HIST1H2BAinteractor190.32763.376Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
89 HIST1H2BBinteractor130.42320.639Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
90 HIST1H2BCinteractor40.8330.083Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
91 HIST1H2BDinteractor50.7000.163Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
92 HIST1H2BHinteractor50.7000.163Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
93 HIST1H2BJinteractor90.4177.880Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
94 HIST1H2BKinteractor70.4761.053Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
95 HIST1H2BLinteractor100.5335.220Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
96 HIST1H2BMinteractor70.5242.186Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
97 HIST1H2BNinteractor60.6000.380Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
98 HIST1H2BOinteractor60.5332.550Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
99 HIST1H3Ainteractor240.304159.386Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
100 HIST1H3Einteractor400.217261.212Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
101 HIST1H4Ainteractor240.45352.300CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
102 HIST2H2AA3interactor50.7000.402Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
103 HIST2H2ABinteractor80.5364.028Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
104 HIST2H2ACinteractor190.49133.573Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
105 HIST2H2BCinteractor100NA
106 HIST2H2BDinteractor100NA
107 HIST2H2BEinteractor170.51519.699Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
108 HIST2H2BFinteractor50.7000.163Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
109 HIST2H3Ainteractor60.7330.211Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
110 HIST3H2Ainteractor50.8000.113Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
111 HIST3H2BBinteractor50.7001.033Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
112 HIST3H3interactor240.319154.156Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
113 HNRNPA1interactor720.298677.125RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
114 HNRNPA1L2interactor41.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
115 HNRNPA2B1oncoprotein290.42960.201RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
116 HNRNPA3oncoprotein260.52935.754IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
117 HNRNPCprotein found in more fusions310.485100.966APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
118 HNRNPCL1interactor40.5001.130FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
XhlA (PF10779, IPR019715): Haemolysin XhlA
119 HNRNPRinteractor420.50490.306RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
120 HNRNPUinteractor540.321369.097CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
121 HNRNPUL2interactor70.5716.374CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
122 HSP90AA1oncoprotein520.280480.174HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
123 HSP90AB1oncoprotein390.370156.939HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
124 HSPA1Ainteractor260.48051.513HSP70 (PF00012, IPR013126): Hsp70 protein
125 HSPA1Linteractor130.50010.667HSP70 (PF00012, IPR013126): Hsp70 protein
126 HSPA2interactor120.7125.556HSP70 (PF00012, IPR013126): Hsp70 protein
127 HSPA6interactor80.8571.204HSP70 (PF00012, IPR013126): Hsp70 protein
128 HSPA7interactor40.8330.145NA
129 HSPA8oncoprotein300.45580.481HSP70 (PF00012, IPR013126): Hsp70 protein
130 HSPA9oncoprotein230.52626.185HSP70 (PF00012, IPR013126): Hsp70 protein
131 IGSF8oncoprotein460.161389.555V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
132 ILF2interactor410.412175.894DZF (PF07528, IPR006561, SM00572): DZF domain
133 ILF3oncoprotein410.360264.558dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
134 ITGA4interactor900.1581507.285FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
135 ITGB3BPinteractor40.6671.000CENP-R (PF06729, IPR009601): Kinetochore component, CENP-R
136 JUPsuppressor150.60013.579Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
137 KPRPinteractor31.0000Protamine_P1 (PF00260, IPR000221): Protamine P1
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Defensin_like (PF10868, IPR022618): Cysteine-rich antifungal protein 2, defensin-like
138 KRT18interactor150.462176.120Filament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
139 KRT19suppressor70.6001.943Filament (PF00038, IPR001664): Intermediate filament protein
140 KRT2interactor60.8000.948Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
141 KRTAP10-7interactor50.5001.648Keratin_B2 (PF01500, IPR002494): Keratin, high sulfur B2 protein
PMG (PF05287, IPR007951): PMG protein
DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
142 L3MBTL1protein found in more fusions80.8101.467MBT (PF02820, IPR004092, SM00561): mbt repeat
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
143 LAGE3interactor60.26716.680Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
144 LANCL1interactor31.0000LANC_like (PF05147, IPR007822): Lanthionine synthetase C-like protein
145 LGALS1interactor110.7097.844Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
146 LMNAprotein found in more fusions270.40671.323Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
147 LRIF1interactor70112.560LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
148 MAGED2interactor130.47424.460CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
MAGE (PF01454, IPR002190): MAGE family
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
149 MATR3protein found in more fusions300.45368.641DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
150 MCM2oncoprotein1600.0978715.745AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
151 MCM3interactor390.281283.172MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
152 MCM4interactor370.348161.012MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
153 MCM6interactor360.355145.141MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
154 MCM7protein found in more fusions400.324233.079MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
155 MCMBPinteractor110.58234.564MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
156 MDFIinteractor31.0000MDFI (PF15316, IPR026134): MyoD family inhibitor
157 MLECinteractor21.0000Malectin (PF11721, IPR021720): Di-glucose binding within endoplasmic reticulum
158 MOB1Asuppressor40.33347.725Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
159 MYBBP1Asuppressor180.50322.328DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
160 MYH9suppressor310.387134.413IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
161 MYO1Cinteractor170.41942.455IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
162 NAT10interactor140.6264.930DUF1726 (PF08351, IPR013562): Domain of unknown function (DUF1726)
Helicase_RecD (PF05127, IPR007807): Helicase
GNAT_acetyltr_2 (PF13718, IPR000182): GNAT acetyltransferase 2
tRNA_bind_2 (PF13725, IPR027992): Possible tRNA binding domain
163 NCLprotein found in more fusions350.362115.259DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
164 NEK9interactor60.6671.914Pkinase (PF00069, IPR000719): Protein kinase domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
165 NESinteractor70.5241.772Anthrax-tox_M (PF09156, IPR015239): Anthrax toxin lethal factor, middle domain
Filament (PF00038, IPR001664): Intermediate filament protein
HSCB_C (PF07743, IPR009073): HSCB C-terminal oligomerisation domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Prominin (PF05478, IPR008795): Prominin
166 NOP2interactor210.486142.422BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II)
Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F
P120R (PF08062, IPR012586): P120R (NUC006) repeat
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477)
FAM176 (PF14851): FAM176 family
Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
167 NOTCH1suppressor130.288116.299Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
168 NTRK1oncoprotein1150.1204911.693I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
169 NUDT3interactor30.33346.385NUDIX (PF00293, IPR000086): NUDIX domain
170 OBSL1interactor830.1681089.158BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
171 ORC1interactor100.8001.968AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
BAH (PF01426, IPR001025, SM00439): BAH domain
Cdc6_C (PF09079, IPR015163, SM01074): CDC6, C terminal winged helix domain
172 ORC2protein found in more fusions160.62910.334ORC2 (PF04084, IPR007220): Origin recognition complex subunit 2
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
173 ORC5interactor140.6679.707AAA_16 (PF13191): AAA ATPase domain
ORC5_C (PF14630, IPR020796): Origin recognition complex (ORC) subunit 5 C-terminus
174 ORC6interactor110.6737.116ORC6 (PF05460, IPR008721): Origin recognition complex subunit 6 (ORC6)
175 PELP1interactor150.36222.848RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
NUC202 (PF08166, IPR012980): NUC202 domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
176 PHB2interactor150.61910.219DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
177 PIPinteractor21.0000SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
178 PKMoncoprotein240.46741.632PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
179 PNKPinteractor70.6672.307PNK3P (PF08645, IPR013954): Polynucleotide kinase 3 phosphatase
AAA_33 (PF13671): AAA domain
180 PRDX1oncoprotein130.6524.569AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
181 PRMT5protein found in more fusions190.340488.902PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
182 PRPF8oncoprotein330.47860.363PRO8NT (PF08082, IPR012591): PRO8NT (NUC069), PrP8 N-terminal domain
PROCN (PF08083, IPR012592): PROCN (NUC071) domain
PROCT (PF08084, IPR012984): PROCT (NUC072) domain
RRM_4 (PF10598, IPR019582): RNA recognition motif of the spliceosomal PrP8
U5_2-snRNA_bdg (PF10597, IPR019581): U5-snRNA binding site 2 of PrP8
U6-snRNA_bdg (PF10596, IPR019580): U6-snRNA interacting domain of PrP8
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PRP8_domainIV (PF12134, IPR021983): PRP8 domain IV core
183 PSMA3protein found in more fusions320.355130.942Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
184 PSMD4interactor90.44411.363UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
185 PUS7interactor60.8000.525R3H (PF01424, IPR001374, SM00393): R3H domain
TruD (PF01142, IPR001656): tRNA pseudouridine synthase D (TruD)
186 PYGBprotein found in more fusions80.6673.218Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
187 PYGLinteractor90.4646.233Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
188 RABGGTBoncoprotein21.0000Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
189 RAD50interactor160.5178.036DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
YscO (PF07321, IPR009929): Type III secretion protein YscO
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2703 (PF10865, IPR021219): Domain of unknown function (DUF2703)
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
AAA_13 (PF13166, IPR026866): AAA domain
AAA_23 (PF13476): AAA domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
190 RALAoncoprotein80.7142.777ArgK (PF03308, IPR005129): ArgK protein
Ras (PF00071, IPR001806, SM00173): Ras family
ThiF (PF00899, IPR000594): ThiF family
191 RBMXsuppressor240.58913.638RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
192 RBMXL1interactor40.8330.120RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
193 RBMXL2interactor100RBM1CTR (PF08081, IPR012604): RBM1CTR (NUC064) family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
194 RBMXL3interactor100RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Atu4866 (PF11512, IPR020955): Agrobacterium tumefaciens protein Atu4866
195 RBPMSprotein found in more fusions40.6670.125RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
196 RNF2interactor620.173705.621zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
197 RPA2oncoprotein590.215734.769RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
198 RPL23interactor160.408385.047Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
199 RPS18interactor130.47414.415Ribosomal_S13 (PF00416, IPR001892): Ribosomal protein S13/S18
200 RPS27Ainteractor110.63611.489DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
201 S100A8oncoprotein90.321149.080S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
202 S100A9oncoprotein140.48715.286S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
203 SBSNinteractor21.0000ApoLp-III (PF07464, IPR010009): Apolipophorin-III precursor (apoLp-III)
Cecropin (PF00272, IPR000875): Cecropin family
Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF3789 (PF12664, IPR024522): Protein of unknown function (DUF3789)
204 SENP3interactor220.32560.506Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
205 SF3A1interactor290.49546.193TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Surp (PF01805, IPR000061, SM00648): Surp module
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
206 SF3A3interactor210.42947.644DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449)
SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
207 SF3B1oncoprotein340.47682.430Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
208 SF3B3interactor340.424110.645CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
209 SFPQoncoprotein320.47577.171GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
210 SH3KBP1protein found in more fusions80.5711.450Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
211 SIRT7interactor570.128694.232DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
212 SLC25A5interactor130.51314.166Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
213 SMG8interactor2035.956Smg8_Smg9 (PF10220, IPR019354): Smg8_Smg9
214 SNAP29protein found in more fusions60.60053.906DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
215 SNCAinteractor160.39023.538Synuclein (PF01387, IPR001058): Synuclein
216 SNRNP200protein found in more fusions340.443513.935DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF603 (PF04645, IPR006739): Protein of unknown function, DUF603
Sec63 (PF02889, IPR004179, SM00973): Sec63 Brl domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
217 SPTBN1suppressor150.40031.396CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Spectrin (PF00435, IPR002017): Spectrin repeat
PH_9 (PF15410): Pleckstrin homology domain
218 SSRP1interactor320.355136.827Rtt106 (PF08512, IPR013719): Histone chaperone Rttp106-like
SSrecog (PF03531, IPR024954): Structure-specific recognition protein (SSRP1)
YABBY (PF04690, IPR006780): YABBY protein
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
CAML (PF14963, IPR016719): Calcium signal-modulating cyclophilin ligand
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
Coilin_N (PF15862, IPR031722): Coilin N-terminus
219 STAT1suppressor90.4299.608SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
220 STK32Cinteractor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
221 SYNCRIPinteractor320.49263.934RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
222 TCEA1oncoprotein80.5713.997Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
TFIIS_C (PF01096, IPR001222): Transcription factor S-II (TFIIS)
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
223 TCP1interactor170.522346.933Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
224 TGM3suppressor40.6670.222Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
225 THRAP3oncoprotein170.49316.377API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
226 TLE4interactor2024.855TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4662 (PF15578, IPR028970): Domain of unknown function (DUF4662)
227 TONSLinteractor170.56719.964LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_12 (PF13424): Tetratricopeptide repeat
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
228 TOP1oncoprotein330.43481.226DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
229 TOP1MTinteractor100Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
230 TOP2Aoncoprotein180.48415.851DNA_gyraseB (PF00204, IPR013506): DNA gyrase B
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Sec62 (PF03839, IPR004728): Translocation protein Sec62
Toprim (PF01751, IPR006171, SM00493): Toprim domain
DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
231 TUBBprotein found in more fusions290.44675.896Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
232 TUBB2Ainteractor100.48926.652Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
233 TUBB2Binteractor130.52641.257Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
234 TUBB3interactor70.7140.965Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
235 TUBB4Ainteractor60.4670.679Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
236 TUBB4Binteractor190.44422.107Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
237 U2AF1oncoprotein180.62111.105DUF1509 (PF07420, IPR010883): Protein of unknown function (DUF1509)
KMP11 (PF03037, IPR004132): Kinetoplastid membrane protein 11
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
238 UBA52interactor100.5336.411Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
239 UBBinteractor100.37817.573ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
240 UBBP4interactor21.0000NA
241 UBCprotein found in more fusions490.296421.050ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
242 USP7oncoprotein280.256495.617MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
243 VCAM1interactor730.1801176.090C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
244 VIMsuppressor170.325105.352Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
245 VPS50interactor80.643190.982Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
246 VPS51interactor100.422351.781DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736)
Vps51 (PF08700): Vps51/Vps67
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
Sec5 (PF15469): Exocyst complex component Sec5
247 VPS52interactor80.619170.224Vps52 (PF04129, IPR007258): Vps52 / Sac2 family
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3
248 VPS53suppressor90.57178.744Vps53_N (PF04100, IPR007234): Vps53-like, N-terminal
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
VPS53_C (PF16854, IPR031745): Vacuolar protein sorting-associated protein 53 C-terminus
249 VPS54interactor51.0000Vps54 (PF07928, IPR012501): Vps54-like protein
Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
SBP_bac_6 (PF13343): Bacterial extracellular solute-binding protein
YqzH (PF14164, IPR025546): YqzH-like protein
250 VWA9interactor100VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
251 WDR36interactor80.6790.886Utp21 (PF04192, IPR007319): Utp21 specific WD40 associated putative domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
252 YBX1oncoprotein210.51022.106CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
253 YEATS2interactor2017.367YEATS (PF03366, IPR005033): YEATS family

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