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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TRPS1, PCGF5 (from a repository: Fri Mar 17 07:20:11 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)45
The number (and %) of the onco-proteins10 (22.22 %)
The number (and %) of the tumor suppressors4 (8.89 %)
Total number of binary PPIs (saturation %)179 (18.08 %)
The number (and %) of affected PPIs44 (24.58 %)
The number of possible different fusions6
PPI diameter5
PPI radius3
The average degree of PPI6.889
Assortativity coefficient-0.2719
The network average Clustering coefficient0.534
The number (and %) of a zero Clustering coefficients7 (15.56 %)
The number (and %) of a zero Betweenness Centrality13 (28.89 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: PCGF5,TRPS1 All fusions
Proteins found in more fusions CSNK2A1 (see 1 fusions); CTBP1 (see 2 fusions); NLK (see 4 fusions); RING1 (see 1 fusions); YWHAZ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 PCGF5parental protein270.249480.622DZR (PF12773, IPR025874): Double zinc ribbon
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
2 TRPS1parental protein170.103487.361Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 AUTS2interactor90.8611.522SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SPX (PF03105, IPR004331): SPX domain
Auts2 (PF15336): Autism susceptibility gene 2 protein
4 BCORoncoprotein110.48987.475Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
5 CBX6interactor51.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
6 CBX7interactor80.7502.799Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
7 CBX8interactor90.6795.225Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
8 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
9 CDK2AP1suppressor30.6679.648CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
10 CEP170P1interactor200NA
11 CSNK2A1oncoprotein150.56041.536Pkinase (PF00069, IPR000719): Protein kinase domain
12 CSNK2A2interactor110.7455.340Pkinase (PF00069, IPR000719): Protein kinase domain
13 CSNK2Binteractor140.436112.056CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
14 CTBP1protein found in more fusions50.66711.4522-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
15 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
16 FBRSinteractor80.8571.273CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Auts2 (PF15336): Autism susceptibility gene 2 protein
17 FBRSL1interactor50.9000.250DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Auts2 (PF15336): Autism susceptibility gene 2 protein
18 FOXJ2interactor2020.617SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
19 HDAC1suppressor110.356181.675FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
20 KIF2Cinteractor31.0000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
21 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
22 MCM6interactor40.33327.495MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
23 NFATC1oncoprotein40.66716.995RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
24 NLKprotein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
25 NLRP3oncoprotein100NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
26 PCGF1interactor130.500108.156zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
27 PHC2interactor90.7862.601SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
28 PLK2suppressor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
29 POLKinteractor2032.695ATP-cone (PF03477, IPR005144): ATP cone domain
IMS (PF00817, IPR001126): impB/mucB/samB family
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
30 PRMT6interactor100Methyltransf_25 (PF13649): Methyltransferase domain
31 RING1protein found in more fusions170.48361.597zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
32 RNF2interactor230.359229.158zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
33 RNF4interactor50.50038.442Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
34 RYBPinteractor110.63612.814DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
35 SEC16Ainteractor40.33363.162APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
36 SUMO1interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
37 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
38 TP53BP1suppressor70.190135.45853-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
39 TRAF2interactor50.6677.094MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
40 TRIM8interactor31.0000dCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
41 UBE2D3interactor80.47667.180UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 UBE2Iinteractor100.306137.242UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
43 XPO1interactor120.379107.222CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
44 YAF2interactor90.7506.583DUF460 (PF04312, IPR007408): Protein of unknown function (DUF460)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Exo5 (PF09810, IPR019190): Exonuclease V - a 5' deoxyribonuclease
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
45 YWHAZprotein found in more fusions40.33323.25514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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