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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins TRPS1, NECTIN4 (from a repository: Mon Jul 29 00:21:30 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins7 (20.00 %)
The number (and %) of the tumor suppressors3 (8.57 %)
Total number of binary PPIs (saturation %)69 (11.60 %)
The number (and %) of affected PPIs33 (47.83 %)
The number of possible different fusions3
PPI diameter2
PPI radiusinf
The average degree of PPI3.143
Assortativity coefficient-0.4754
The network average Clustering coefficient0.522
The number (and %) of a zero Clustering coefficients13 (37.14 %)
The number (and %) of a zero Betweenness Centrality29 (82.86 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: NECTIN4,TRPS1 All fusions
Proteins found in more fusions CTBP1 (see 2 fusions); NLK (see 4 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 NECTIN4parental protein160.067224.000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
2 TRPS1parental protein170.103220.667Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_7 (PF15269): Zinc-finger
3 C6orf62interactor100DUF4566 (PF15130, IPR027903): Domain of unknown function (DUF4566)
4 CDK18oncoprotein100APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 CDK2AP1suppressor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
6 CEP170P1interactor200NA
7 CTBP1protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
8 CTSAinteractor100Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
9 DYNLL1interactor31.0000Dynein_light (PF01221, IPR001372): Dynein light chain type 1
10 EIF2B1interactor51.0000IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
11 EIF2B2interactor41.0000IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
12 EIF2B3interactor41.0000NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
DUF4954 (PF16314, IPR032533): Domain of unknown function (DUF4954)
13 EIF2B4interactor41.0000IF-2B (PF01008, IPR000649): Initiation factor 2 subunit family
Mpp10 (PF04006, IPR007151): Mpp10 protein
14 ENAHoncoprotein21.0000MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
15 EVLoncoprotein31.0000VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
16 FBXO10interactor100Adeno_E1B_55K (PF01696, IPR002612): Adenovirus EB1 55K protein / large t-antigen
NosD (PF05048, IPR007742): Periplasmic copper-binding protein (NosD)
F-box-like (PF12937, IPR001810): F-box-like
Beta_helix (PF13229): Right handed beta helix region
MRI (PF15325, IPR028278): Modulator of retrovirus infection
17 FOXJ2interactor100SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
18 HDAC1suppressor60.6003.667FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
19 MAPK3oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
20 MCM6interactor31.0000MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
YmgB (PF10798, IPR024753): Biofilm development protein YmgB/AriR
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
21 NECTIN1interactor200C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
22 NECTIN2interactor31.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
23 NFATC1oncoprotein40.6672.000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
24 NLKprotein found in more fusions200Pkinase (PF00069, IPR000719): Protein kinase domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
25 PDSS1interactor100polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
26 PIGUinteractor100PIG-U (PF06728, IPR009600): GPI transamidase subunit PIG-U
27 RNF4interactor41.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
28 RRP1interactor100Nop52 (PF05997, IPR010301): Nucleolar protein,Nop52
Tn7_Tnp_TnsA_C (PF08721, IPR014832): TnsA endonuclease C terminal
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
29 SEC16Ainteractor100APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
30 SUMO1interactor41.0000Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
31 TEAD2interactor21.0000TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
32 TIGITinteractor21.0000Cpta_toxin (PF07254, IPR009883): Membrane-bound toxin component of toxin-antitoxin system
NMN_transporter (PF04973, IPR006419): Nicotinamide mononucleotide transporter
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
33 TP53BP1suppressor50.4006.00053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
34 UBE2Iinteractor80.42911.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
35 ZNF582interactor100A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
YhfH (PF14149, IPR025432): YhfH-like protein

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